5-((Trimethylsilyl)ethynyl)pyrimidine

Product Name: 5-((Trimethylsilyl)ethynyl)pyrimidine
CAS No.: 216309-28-3
Chemical Name: 5-((Trimethylsilyl)ethynyl)pyrimidine
Synonyms: 5-(2-TMS-ethynyl)pyrimidine;5-trimethylsilanylethynyl-pyrimidine;5-((Trimethylsilyl)ethynyl)pyrimidine;Pyrimidine, 5-[2-(trimethylsilyl)ethynyl]-
CBNumber: CB32471676
Molecular Formula: C9H12N2Si
Formula Weight: 176.29
MOL File: 216309-28-3.mol

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5-((Trimethylsilyl)ethynyl)pyrimidine Property

Boiling point:: 223.5±22.0 °C(Predicted)
Density: 0.99±0.1 g/cm3(Predicted)
storage temp.: 2-8°C
pka: 1.98±0.10(Predicted)

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Safety

WGK Germany: 3
HS Code: 2931900090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

American Custom Chemicals Corporation

Product number: ORS0001704
Product name: 5-((TRIMETHYLSILYL)ETHYNYL)PYRIMIDINE
Purity: 95.00%
Packaging: 250MG
Price: $213.15
Updated: 2021/12/16

SynQuest Laboratories

Product number: 7H80-1-07
Product name: 5-((Trimethylsilyl)ethynyl)pyrimidine
Purity: 95%
Packaging: 250mg
Price: $288
Updated: 2021/12/16

AK Scientific

Product number: W4487
Product name: 5-((Trimethylsilyl)ethynyl)pyrimidine
Packaging: 1g
Price: $288
Updated: 2021/12/16

Matrix Scientific

Product number: 073752
Product name: 5-((Trimethylsilyl)ethynyl)pyrimidine
Purity: 95+%
Packaging: 250mg
Price: $324
Updated: 2021/12/16

Activate Scientific

Product number: AS110404
Product name: 5-((Trimethylsilyl)ethynyl)pyrimidine
Purity: 97%
Packaging: 1g
Price: $345
Updated: 2021/12/16

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5-((Trimethylsilyl)ethynyl)pyrimidine Chemical Properties,Usage,Production

Synthesis

4595-59-9

1066-54-2

216309-28-3

Example 3: Synthesis of 5-((trimethylsilyl)ethynyl)pyrimidine Tetrakis(triphenylphosphine)palladium(0) (727 mg, 0.6 mmol) was added to a stirred, degassed toluene suspension of 5-bromopyrimidine (5.0 g, 31.4 mmol) and cuprous(I) iodide (120 mg, 0.6 mmol) under nitrogen protection. Diisopropylamine (1:1, 200 mL) was then added. The reaction mixture was heated to 60 °C and then trimethylmethylsilylacetylene (4.89 mL, 34.6 mmol) was slowly added. The reaction mixture was stirred continuously at 60 °C for 3 hours. After completion of the reaction, the mixture was cooled to room temperature and diluted with ether. It was washed sequentially with ethyl acetate (200 mL) and saturated aqueous ammonium chloride solution (3 x 100 mL). The organic layer was separated and dried with anhydrous magnesium sulfate and subsequently concentrated under reduced pressure. The crude product was purified by fast column chromatography (5% ethyl acetate/heptane as eluent) to afford 5-((trimethylmethylsilyl)ethynyl)pyrimidine as a light brown solid in a yield of 4.71 g (85% yield). Liquid chromatography (LC) detection conditions: wavelength 215 nm; retention time (Rt) 2.07 min, purity 88%. Mass spectrum (ES+): m/z 177 ([M+H]+).

References

[1] Monatshefte fur Chemie, 1998, vol. 129, # 10, p. 1035 - 1048
[2] Patent: US2008/70931, 2008, A1. Location in patent: Page/Page column 12
[3] Organic and biomolecular chemistry, 2003, vol. 1, # 3, p. 498 - 506
[4] Journal of Organic Chemistry, 2007, vol. 72, # 13, p. 4750 - 4755
[5] Patent: WO2003/91226, 2003, A1. Location in patent: Page/Page column 47

5-((Trimethylsilyl)ethynyl)pyrimidine Preparation Products And Raw materials

Raw materials

Preparation Products

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5-((Trimethylsilyl)ethynyl)pyrimidine Suppliers

China 29 India 1 United States 6 Global 36

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