ChemicalBook > CAS DataBase List > 5-Chloro-3-methylpyridine-2-carbonitrile

5-Chloro-3-methylpyridine-2-carbonitrile

Product Name
5-Chloro-3-methylpyridine-2-carbonitrile
CAS No.
156072-84-3
Chemical Name
5-Chloro-3-methylpyridine-2-carbonitrile
Synonyms
5-Chloro-3-Methylpicolinonitrile;5-chloro-3-methyl-2-Pyridinecarbonitrile;5-Chloro-3-methylpyridine-2-carbonitrile;2-Pyridinecarbonitrile, 5-chloro-3-methyl-;5-Chloro-2-cyano-3-methylpyridine, 5-Chloro-3-methylpicolinonitrile
CBNumber
CB92526394
Molecular Formula
C7H5ClN2
Formula Weight
152.58
MOL File
156072-84-3.mol
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5-Chloro-3-methylpyridine-2-carbonitrile Property

storage temp. 
Store at room temperature
Appearance
Light yellow to brown Solid
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Safety

HS Code 
2933399990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
C587635
Product name
5-Chloro-3-methylpyridine-2-carbonitrile
Packaging
1g
Price
$75
Updated
2021/12/16
Biosynth Carbosynth
Product number
FC140122
Product name
5-Chloro-3-methylpicolinonitrile
Packaging
500mg
Price
$100
Updated
2021/12/16
AK Scientific
Product number
Z4212
Product name
5-Chloro-3-methylpicolinonitrile
Packaging
1g
Price
$144
Updated
2021/12/16
Biosynth Carbosynth
Product number
FC140122
Product name
5-Chloro-3-methylpicolinonitrile
Packaging
1g
Price
$160
Updated
2021/12/16
Biosynth Carbosynth
Product number
FC140122
Product name
5-Chloro-3-methylpicolinonitrile
Packaging
250mg
Price
$60
Updated
2021/12/16
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5-Chloro-3-methylpyridine-2-carbonitrile Chemical Properties,Usage,Production

Synthesis

557-21-1

65550-77-8

156072-84-3

2-Bromo-5-chloro-3-methylpyridine (45 g, 218 mmol) and zinc cyanide (8.30 mL, 131 mmol) were added to a tris(dibenzylideneacetone)dipalladium(0) (4.99 g, 5.45 mmol) and 1,1'-bis(diphenylphosphino)ferrocene (6.04 g, 10.90 mmol) dimethylacetamide (40 mL ) solution. The mixture was heated to 110 °C and reacted for 4 hours. After completion of the reaction, it was cooled to room temperature, the reaction mixture was diluted with water and extracted with ethyl acetate. The organic phases were combined and concentrated under reduced pressure, and the resulting residue was purified by silica gel column chromatography using an ISCO system eluting with a 0-60% ethyl acetate/hexane gradient to afford the target product 2-cyano-3-methyl-5-chloropyridine (25.4 g, 166 mmol, 76% yield). The product was detected by LC/MS (ESI+) with m/z = 153.1 ([M+H]+).

References

[1] Patent: WO2014/138484, 2014, A1. Location in patent: Page/Page column 143
[2] Patent: US2015/38497, 2015, A1. Location in patent: Paragraph 0993
[3] Patent: WO2016/22724, 2016, A1. Location in patent: Page/Page column 294; 295

5-Chloro-3-methylpyridine-2-carbonitrile Preparation Products And Raw materials

Raw materials

Preparation Products

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5-Chloro-3-methylpyridine-2-carbonitrile Suppliers

China 37 Germany 1 India 2 United Kingdom 2 United States 8 Global 50
J & K SCIENTIFIC LTD.
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18210857532; 18210857532
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86-10-82849933
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18270980682
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NovoChemy Ltd.
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Tianjing Geneston Bio-tech Co.,Ltd.
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Bellen Chemistry Co., Ltd.
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Shanghai Kahn Pharmaceutical Co., Ltd.
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Amadis Chemical Company Limited
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571-89925085
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0086-571-89925065
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sales@amadischem.com
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View Lastest Price from 5-Chloro-3-methylpyridine-2-carbonitrile manufacturers

Career Henan Chemical Co
Product
5-Chloro-3-methylpyridine-2-carbonitrile 156072-84-3
Price
US $7.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
100KG
Release date
2020-02-13
Career Henan Chemical Co
Product
5-Chloro-3-methylpyridine-2-carbonitrile 156072-84-3
Price
US $7.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
100KG
Release date
2020-02-13

156072-84-3, 5-Chloro-3-methylpyridine-2-carbonitrileRelated Search:

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