1-Pyrrolidinecarboxylic acid, 3-ethynyl-, 1,1-dimethylethyl ester
- Product Name
- 1-Pyrrolidinecarboxylic acid, 3-ethynyl-, 1,1-dimethylethyl ester
- CAS No.
- 287193-00-4
- Chemical Name
- 1-Pyrrolidinecarboxylic acid, 3-ethynyl-, 1,1-dimethylethyl ester
- Synonyms
- 1-Boc-3-ethynylpyrrolidine;1-Boc-3-ethynylpyrrolidin...;acid, 3-ethynyl-, 1,1-dimethylethyl ester;tert-Butyl 3-ethynyl-1-pyrrolidinecarboxylate;tert-butyl 3-ethynylpyrrolidine-1-carboxylate;1,1-Dimethylethyl 3-ethynyl-1-pyrrolidinecarboxylate;1-Pyrrolidinecarboxylic acid, 3-ethynyl-,1,1-dimethyl ester;3-ethynyl-1-Pyrrolidinecarboxylic acid 1,1-dimethylethyl ester;1-Pyrrolidinecarboxylic acid, 3-ethynyl-, 1,1-dimethylethyl ester;1-Pyrrolidinecarboxylic acid, 3-ethynyl-,1,1-dimethyl ester - [P7677]
- CBNumber
- CB32473670
- Molecular Formula
- C11H17NO2
- Formula Weight
- 195.26
- MOL File
- 287193-00-4.mol
1-Pyrrolidinecarboxylic acid, 3-ethynyl-, 1,1-dimethylethyl ester Property
- Boiling point:
- 249.2±29.0 °C(Predicted)
- Density
- 1.04±0.1 g/cm3(Predicted)
- storage temp.
- 2-8°C
- form
- solid
- pka
- -2.53±0.40(Predicted)
- Appearance
- White to off-white Solid
- optical activity
- 0.9898°(C=0.1566g/100ml MEOH)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- B703980
- Product name
- tert-butyl3-ethynylpyrrolidine-1-carboxylate
- Packaging
- 100mg
- Price
- $265
- Updated
- 2021/12/16
- Product number
- FB141606
- Product name
- tert-Butyl 3-ethynylpyrrolidine-1-carboxylate
- Packaging
- 500mg
- Price
- $430
- Updated
- 2021/12/16
- Product number
- AS17323
- Product name
- 1-Boc-3-ethynylpyrrolidine
- Purity
- 96%
- Packaging
- 5G
- Price
- $592
- Updated
- 2021/12/16
- Product number
- FB141606
- Product name
- tert-Butyl 3-ethynylpyrrolidine-1-carboxylate
- Packaging
- 1g
- Price
- $743.75
- Updated
- 2021/12/16
- Product number
- P7677
- Product name
- 1-Pyrrolidinecarboxylicacid,3-ethynyl-,1,1-dimethylester
- Purity
- 97.0%
- Packaging
- 25g
- Price
- $1310
- Updated
- 2021/12/16
1-Pyrrolidinecarboxylic acid, 3-ethynyl-, 1,1-dimethylethyl ester Chemical Properties,Usage,Production
Application
tert-butyl 3-ethynylpyrrolidine-1-carboxylate is a useful research chemical.
Synthesis
90965-06-3
59379-02-1
287193-00-4
GENERAL STEPS: 1-Boc-3-pyrrolidinecarboxaldehyde (580 mg, 2.91 mmol) was dissolved in methanol (15 mL) at room temperature, and potassium carbonate (1.00 g, 7.28 mmol) and dimethyl (1-diazido-2-oxopropyl)phosphonate (839 mg, 4.37 mmol) were added sequentially. The reaction mixture was stirred at room temperature for 3 h. After completion of the reaction, it was filtered through a short diatomaceous earth pad and the filtrate was concentrated under reduced pressure. The resulting crude product was purified by silica gel column chromatography with an eluent gradient of 0 to 50% ethyl acetate/hexane to give a colorless oily product. The product was allowed to stand in a refrigerator and cured to give 1-Boc-3-ynylpyrrolidine white solid (374 mg, 66% yield).
References
[1] Journal of Medicinal Chemistry, 2018, vol. 61, # 18, p. 8417 - 8443
[2] Patent: US2016/9720, 2016, A1. Location in patent: Paragraph 0250
[3] Patent: US2016/9711, 2016, A1. Location in patent: Paragraph 0242; 0243; 0244
1-Pyrrolidinecarboxylic acid, 3-ethynyl-, 1,1-dimethylethyl ester Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 1-Pyrrolidinecarboxylic acid, 3-ethynyl-, 1,1-dimethylethyl ester manufacturers
- Product
- 1-Pyrrolidinecarboxylic acid, 3-ethynyl-, 1,1-dimethylethyl ester 287193-00-4
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-09-26
- Product
- 1-Pyrrolidinecarboxylic acid, 3-ethynyl-, 1,1-dimethylethyl ester 287193-00-4
- Price
- US $9.80/KG
- Min. Order
- 1g
- Purity
- ≥99%
- Supply Ability
- 100kg
- Release date
- 2020-01-14