1-(4-BOC-piperidyl)-4-iodopyrazole

Uses Uses

Product Name: 1-(4-BOC-piperidyl)-4-iodopyrazole
CAS No.: 877399-73-0
Chemical Name: 1-(4-BOC-piperidyl)-4-iodopyrazole
Synonyms: tert-butyl 4-(4-iodo-1H-pyrazol-1-yl)piperidine-1-carboxylate;Crizotinib Impurity 16;CrizotinibIntermediate1;1-(4-BOC-piperidyl)-4-iodopyrazole;1-(4-BOC-piperazino)-4-iodopyrazole;1-(1-Boc-4-piperidinyl)-4-iodopyrazole;1-Boc-4-(4-iodo-1H-pyrazol-1-yl)piperidine;1-(1-Boc-4-piperidinyl)-4-iodopyrazole, 98%;4-(4-iodo-1H-pyrazol-1-yl)piperidine-1-carboxylate;tert-Butyl 4-(4-iodopyrazolyl)piperidinecarboxylate
CBNumber: CB32473791
Molecular Formula: C13H20IN3O2
Formula Weight: 377.22
MOL File: 877399-73-0.mol

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1-(4-BOC-piperidyl)-4-iodopyrazole Property

Melting point:: 97 °C
Boiling point:: 430.6±35.0 °C(Predicted)
Density: 1.60±0.1 g/cm3(Predicted)
storage temp.: 2-8°C(protect from light)
form: Solid
pka: 1.08±0.19(Predicted)
Appearance: White to off-white Solid
Sensitive: Light Sensitive
InChI: InChI=1S/C13H20IN3O2/c1-13(2,3)19-12(18)16-6-4-11(5-7-16)17-9-10(14)8-15-17/h8-9,11H,4-7H2,1-3H3
InChIKey: IONGFFYQZADMPH-UHFFFAOYSA-N
SMILES: N1(C(OC(C)(C)C)=O)CCC(N2C=C(I)C=N2)CC1

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TRC

Product number: B809635
Product name: tert-Butyl4-(4-Iodo-1H-pyrazol-1-yl)piperidine-1-carboxylate
Packaging: 25g
Price: $130
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0037519
Product name: 1-(4-BOC-PIPERAZINO)-4-IODOPYRAZOLE
Purity: 95.00%
Packaging: 1G
Price: $848.93
Updated: 2021/12/16

Matrix Scientific

Product number: 089887
Product name: 1-Boc-4-(4-Iodo-1H-pyrazol-1-yl)piperidine
Purity: 95+%
Packaging: 5g
Price: $1260
Updated: 2021/12/16

Matrix Scientific

Product number: 089887
Product name: 1-Boc-4-(4-Iodo-1H-pyrazol-1-yl)piperidine
Purity: 95+%
Packaging: 250mg
Price: $208
Updated: 2021/12/16

AK Scientific

Product number: V8549
Product name: 1-(4-BOC-piperidyl)-4-iodopyrazole
Packaging: 10g
Price: $384
Updated: 2021/12/16

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1-(4-BOC-piperidyl)-4-iodopyrazole Chemical Properties,Usage,Production

Uses

4-(4-iodo-1H-pyrazol-1-yl)-1-piperidinecarboxylic acid-1,1-dimethyl ethyl ester is a useful research chemical.

Uses

4-(4-iodo-1H-pyrazol-1-yl)-1-piperidinecarboxylic acid-1,1-dimethyl ethyl ester is an organic heterocyclic compound that can be used as a pharmaceutical intermediate.

Synthesis

1-(4-BOC-piperidyl)-4-iodopyrazole is prepared by the reaction of 4-Iodopyrazole and 1-Boc-4-methanesulfonyloxypiperidine. The specific synthesis steps are as follows:
To a stirred solution of 4-iodo-lH-pyrazole (8.98 g, 46.28 mmol) in DCM (160 mL) was added NaH (1.67 g, 55.53 mmol, 80percent NaH/mineral oil) portion-wise at 0 °C. The mixture was stirred at 0 °C for 1 hour, then tert-butyl 4-((methylsulfonyl)oxy)piperidine-l- carboxylate (14.22 g, 50.90 mmol) was added. The resulted mixture was stirred at 100 °C for 15 hours, then cooled to rt, quenched with H20 (30 mL) and concentrated in vacuo. The residue was diluted with H20 (150 mL), and the mixture was extracted with EtOAc (100 mL x 5). The combined organic layers were dried over anhydrous Na2S04 and concentrated in vacuo. The residue was purified by a silica gel column chromatography (PE/EtOAc (v/v) = 5/1) to give 1-(4-BOC-piperidyl)-4-iodopyrazole as a white solid (12.25 g, 70.2percent>). MS (ESI, pos. ion) m/z: 322.0 (M-56+1).

References

[1] Patent: WO2014/193647, 2014, A2. Location in patent: Paragraph 0184
[2] Patent: CN104119331, 2018, B. Location in patent: Paragraph 0382; 0387; 0388
[3] Patent: EP2650293, 2013, A1. Location in patent: Paragraph 0195; 0196
[4] Patent: US2008/300273, 2008, A1
[5] Patent: US2008/293769, 2008, A1. Location in patent: Page/Page column 6

1-(4-BOC-piperidyl)-4-iodopyrazole Preparation Products And Raw materials

Raw materials

Preparation Products

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1-(4-BOC-piperidyl)-4-iodopyrazole Suppliers

China 158 Germany 1 India 2 United Kingdom 1 United States 8 Global 170

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View Lastest Price from 1-(4-BOC-piperidyl)-4-iodopyrazole manufacturers

Henan Aochuang Chemical Co.,Ltd.

Product: 1-Piperidinecarboxylic acid, 4-(4-iodo-1H-pyrazol-1-yl)-, 1,1-dimethylethyl ester 877399-73-0
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-10-08

Henan Fengda Chemical Co., Ltd

Product: 1-PIPERIDINECARBOXYLIC ACID 4-(4-IODO-1H-PYRAZOL-1YL)-,1-1-DIMETHYLETHYLESTER 877399-73-0
Price: US $200.00-1.00/KG
Min. Order: 1KG
Purity: 99%, 99.5% Sublimated
Supply Ability: g-kg-tons, free sample is available
Release date: 2023-12-31

Zhuozhou Wenxi import and Export Co., Ltd

Product: 1-Piperidinecarboxylic acid, 4-(4-iodo-1H-pyrazol-1-yl)-, 1,1-dimethylethyl ester 877399-73-0
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-10

877399-73-0, 1-(4-BOC-piperidyl)-4-iodopyrazoleRelated Search:

Pyrazole Piperidinylpiperidine

1-Piperidinecarboxylic acid, 4-(4-iodo-1H-pyrazol-1-yl)-, 1,1-dimethylethyl ester

Crizotinib Impurity 16

tert-butyl 4-(4-iodo-1H-pyrazol-1-yl)piperidine-1-carboxylate

1-(4-BOC-piperazino)-4-iodopyrazole

1-(4-BOC-piperidyl)-4-iodopyrazole

1-Boc-4-(4-iodo-1H-pyrazol-1-yl)piperidine

4-(4-Iodo-pyrazol-1-yl)-piperidine-1-carboxylic acid tert-butyl ester

tert-Butyl 4-(4-iodopyrazolyl)piperidinecarboxylate

1-Piperidinecarboxylic acid, 4-(4-iodo-1H-pyrazol-1-yl)-

1-(1-Boc-4-piperidinyl)-4-iodopyrazole

tert-butyl 4-(4-iodopyrazol-1-yl)piperidine-1-carboxylate

1-(1-Boc-4-piperidinyl)-4-iodopyrazole, 98%

CrizotinibIntermediate1

4-(4-iodo-1H-pyrazol-1-yl)piperidine-1-carboxylate

4-(4-Iodo-1H-pyrazol-1-yl)-1-piperidinecarboxylicacid1,1-dimethylester

4-(4-Iodo-1H-pyrazol-1-yl)-1-piperidinecarboxylicacid1,1-dimethylethylester

877399-73-0

877399-70-3