Ferrostatin-1 (Fer-1)
- Product Name
- Ferrostatin-1 (Fer-1)
- CAS No.
- 347174-05-4
- Chemical Name
- Ferrostatin-1 (Fer-1)
- Synonyms
- Fer1;Fer 1;Fer-1;3-amino-4-(cycL;CCP.347174-05-4-G-1;Ferrostatin-1 (Fer-1);Ferrostatin-1 (Fer-1) USP/EP/BP;Ethyl 3-amino-4-(cyclohexylamino)benzoate;3-Amino-4-cyclohexylaminobenzoic acid ethyl ester;Benzoic acid, 3-amino-4-(cyclohexylamino)-, ethyl ester
- CBNumber
- CB32484317
- Molecular Formula
- C15H22N2O2
- Formula Weight
- 262.35
- MOL File
- 347174-05-4.mol
Ferrostatin-1 (Fer-1) Property
- Boiling point:
- 437.3±35.0 °C(Predicted)
- Density
- 1.150±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- DMSO: soluble10mg/mL, clear
- form
- powder
- pka
- 4.78±0.11(Predicted)
- color
- purple to brown
- Stability:
- Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.
- InChIKey
- UJHBVMHOBZBWMX-UHFFFAOYSA-N
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- SML0583
- Product name
- Ferrostatin-1
- Purity
- ≥95% (HPLC)
- Packaging
- 5mg
- Price
- $79.7
- Updated
- 2024/03/01
- Product number
- SML0583
- Product name
- Ferrostatin-1
- Purity
- ≥95% (HPLC)
- Packaging
- 25mg
- Price
- $324
- Updated
- 2024/03/01
- Product number
- 17729
- Product name
- Ferrostatin-1
- Purity
- ≥90%
- Packaging
- 5mg
- Price
- $50
- Updated
- 2024/03/01
- Product number
- 17729
- Product name
- Ferrostatin-1
- Purity
- ≥90%
- Packaging
- 10mg
- Price
- $94
- Updated
- 2024/03/01
- Product number
- 17729
- Product name
- Ferrostatin-1
- Purity
- ≥90%
- Packaging
- 25mg
- Price
- $177
- Updated
- 2024/03/01
Ferrostatin-1 (Fer-1) Chemical Properties,Usage,Production
Description
Ferrostatin-1 (347174-05-4) inhibits ferroptosis (EC50=60 nM), an iron-dependent form of nonapoptotic cell death.1?Potent inhibitor of ferroptosis in cancer cells and glutamate-induced cell death in organotypic rat brain slices.1?Blocks the cytotoxic effects of sorafenib in hepatocellular carcinoma cells.2?Ferrostatin-1 inhibits oxidative lipid damage and cell death in diverse disease models3 and prevents apoptosis of renal proximal tubular cells induced by reactive oxygen species4.
Uses
Ferrostatin-1 (Fer-1) is a potent and selective inhibitor of ferroptosis.
Definition
ChEBI: Ferrostatin-1 is an ethyl ester resulting from the formal condensation of the carboxy group of 3-amino-4-(cyclohexylamino)benzoic acid with ethanol. It is a potent inhibitor of ferroptosis, a distinct non-apoptotic form of cell death caused by lipid peroxidation. It is also a radical-trapping antioxidant and has the ability to reduce the accumulation of lipid peroxides and chain-carrying peroxyl radicals. It has a role as a ferroptosis inhibitor, a radiation protective agent, an antioxidant, a radical scavenger, an antifungal agent and a neuroprotective agent. It is a substituted aniline, an ethyl ester and a primary arylamine.
Biochem/physiol Actions
Ferrostatin-1 is an active radical-trapping antioxidant that traps peroxyl radicals, and thus serves as a potential inhibitor of ferroptosis. Ferroptosis is considered as regulated necrosis, which differs from apoptosis and autophagy. Ferrostatin-1 is known to show protective effects against Huntington′s disease and also prevents neurotoxicity induced by glutamate in cellular models.
storage
Store at +4°C
References
1) Dixon et al. (2012), Ferroptosis: an iron-dependent form of nonapoptotic cell death; Cell, 149 1060 2) Louandre et al. (2013), Iron-dependent cell death of hepatocellular carcinoma cells exposed to sorafenib; Int. J. Cancer, 133 1732 3) Skouta et al. (2014), Ferrostatins inhibit oxidative lipid damage and cell death in diverse disease models; J. Am. Chem. Soc., 136 4551 4) Nowak et al. (2013), Protein kinase C-α interaction with iHSP70 in mitochondria promotes recovery of mitochondrial function after injury in renal proximal tubular cells; Am. J. Physiol. Renal. Physiol., 305 F764
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View Lastest Price from Ferrostatin-1 (Fer-1) manufacturers
- Product
- Ferrostatin-1 (Fer-1) 347174-05-4
- Price
- US $1.00/g
- Min. Order
- 1g
- Purity
- 99.99%
- Supply Ability
- 200kg
- Release date
- 2019-12-20