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N-(2-Aminophenyl)-N'-phenylheptanediamide

Product Name
N-(2-Aminophenyl)-N'-phenylheptanediamide
CAS No.
537034-15-4
Chemical Name
N-(2-Aminophenyl)-N'-phenylheptanediamide
Synonyms
NKL 22;HDACi-4b;MDK-4154;NKL22, >98%;NKL 22, >98%;HDACi-4b (NKL22;HDAC inhibitor IV;NKL 22, 10 mM in DMSO;Histone Deacetylase Inhibitor IV;N-(2-Aminophenyl)-N'-phenylheptanediamide
CBNumber
CB32486755
Molecular Formula
C19H23N3O2
Formula Weight
325.4
MOL File
537034-15-4.mol
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N-(2-Aminophenyl)-N'-phenylheptanediamide Property

Melting point:
159-161°C
Boiling point:
627.9±40.0 °C(Predicted)
Density 
1.212±0.06 g/cm3(Predicted)
storage temp. 
-20°C Freezer
solubility 
DMSO, Methanol
form 
Beige solid
pka
14?+-.0.70(Predicted)
color 
Off-White to Pale Beige
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
382170
Product name
Histone Deacetylase Inhibitor IV - CAS 537034-15-4 - Calbiochem
Packaging
10mg
Price
$335
Updated
2023/01/07
Cayman Chemical
Product number
22942
Product name
PAOA
Purity
≥95%
Packaging
5mg
Price
$93
Updated
2024/03/01
Cayman Chemical
Product number
22942
Product name
PAOA
Purity
≥95%
Packaging
10mg
Price
$176
Updated
2024/03/01
Cayman Chemical
Product number
22942
Product name
PAOA
Purity
≥95%
Packaging
25mg
Price
$412
Updated
2024/03/01
TRC
Product number
A625980
Product name
N-(2-Aminophenyl)-N’-phenylheptanediamide
Packaging
5mg
Price
$120
Updated
2021/12/16
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N-(2-Aminophenyl)-N'-phenylheptanediamide Chemical Properties,Usage,Production

Chemical Properties

Off-White Solid

Uses

Histone deacetylase inhibitor IV. A cell-permeable pimeloylanilide compound that acts as a FXN-(frataxin gene) specific HDAC inhibitor. Reverses the silencing of FXN transcription in FRDA (Friedrich’s ataxia) cells due to hypoacetylation of histones H3 and H4.

General Description

A cell-permeable pimeloylanilide compound that acts as a FXN- (frataxin gene) specific HDAC (histone deacetylase) inhibitor. Reverses the silencing of FXN transcription in FRDA (Friedreich′s ataxia) cells (~3-fold increase of FXN mRNA at 5 μM in primary FRDA lymphocytes and ~3-fold frataxin expression in FRDA cell line at 2.5 μM) due to hypoacetylation of histones H3 and H4 by increasing acetylation at H3K14, H4K5 and H4K12, without significant changes in acetylation at H3K9, H4K8 and H4K16. In comparison, Trichostatin-A (Cat. No. 647925 and 647926) and SAHA, two other commonly used HDAC inhibitors, exhibit no effect on FXN transcription.

Biochem/physiol Actions

Cell permeable: yes

IC 50

HDAC1: 0.199 μM (IC50); HDAC2: 1.59 μM (IC50); HDAC3: 0.069 μM (IC50); HDAC8: 5 μM (IC50)

N-(2-Aminophenyl)-N'-phenylheptanediamide Preparation Products And Raw materials

Raw materials

Preparation Products

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N-(2-Aminophenyl)-N'-phenylheptanediamide Suppliers

Canada 1 China 75 United Kingdom 1 United States 9 Global 86
Musechem
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info@musechem.com
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United States
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+1-781-999-5354; +17819995354
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marketing@targetmol.com
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United States
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InvivoChem
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+1-708-310-1919 +1-13798911105
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708-557-7486
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sales@invivochem.cn
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Aladdin Scientific
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TargetMol Chemicals Inc.
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+1-781-999-5354;
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support@targetmol.com
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United States
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Cayman Chemical Company
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cayman@caymanchem.com
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United States
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537034-15-4, N-(2-Aminophenyl)-N'-phenylheptanediamideRelated Search:


  • N-(2-Aminophenyl)-N'-phenylheptanediamide
  • N1-(2-AMinophenyl)-N7-phenylheptanediaMide
  • NKL 22
  • HDAC inhibitor IV
  • Histone Deacetylase Inhibitor IV
  • HDACi-4b
  • HISTONE DEACETYLASE INHIBITOR IV;NKL22;NKL-22;NKL 22
  • NKL 22, >98%
  • NKL22, >98%
  • MDK-4154
  • Histone Deacetylase Inhibitor IV - CAS 537034-15-4 - Calbiochem
  • Heptanediamide, N1-(2-aminophenyl)-N7-phenyl-
  • Huntington's,abnormalities,histone,NKL 22,Histone deacetylases,transcriptional,HDAC,NKL-22,Inhibitor,deacetylases,phenotype,inhibit,NKL22
  • N-(2-Aminophenyl)-N’-phenylheptanediamide
  • NKL 22, 10 mM in DMSO
  • HDACi-4b (NKL22
  • 537034-15-4
  • Amines
  • Aromatics
  • Inhibitors
  • Intermediates & Fine Chemicals
  • Pharmaceuticals