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Slv320

Product Name
Slv320
CAS No.
251945-92-3
Chemical Name
Slv320
Synonyms
Slv320;SC-204288;Derenofylline;SLV320 >=98% (HPLC);Derenofylline, 10 mM in DMSO;SLV320; SLV-320; SLV 320; DERENOFYLLINE;4-[(2-phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]cyclohexanol;4-[(2-phenyl-7H-pyrrolo[2， 3-d]pyrimidin-4-yl)amino]cyclohexan-1-ol;(1R,4R)-4-(2-Phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)cyclohexanol;trans-4-[(2-Phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]cyclohexanol
CBNumber
CB32492503
Molecular Formula
C18H20N4O
Formula Weight
308.38
MOL File
251945-92-3.mol
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Slv320 Property

Boiling point:
532.3±60.0 °C(Predicted)
Density 
1.37±0.1 g/cm3(Predicted)
storage temp. 
Keep in dark place,Sealed in dry,2-8°C
solubility 
Soluble to 100 mM in DMSO and to 50 mM in ethanol
form 
Powder
pka
15.15±0.40(Predicted)
color 
White to off-white
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML1931
Product name
SLV320
Purity
≥98% (HPLC)
Packaging
5 mg
Price
$91.8
Updated
2025/07/31
Cayman Chemical
Product number
27666
Product name
Derenofylline
Packaging
5mg
Price
$92
Updated
2024/03/01
Cayman Chemical
Product number
27666
Product name
Derenofylline
Packaging
25mg
Price
$371
Updated
2024/03/01
Cayman Chemical
Product number
27666
Product name
Derenofylline
Packaging
1mg
Price
$34
Updated
2024/03/01
Cayman Chemical
Product number
27666
Product name
Derenofylline
Packaging
10mg
Price
$166
Updated
2024/03/01
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Slv320 Chemical Properties,Usage,Production

Description

Derenofylline is an adenosine A1 receptor antagonist (Ki = 1 nM). It is selective for adenosine A1 over A2A, A2B, and A3 receptors (Kis = 398, 3,981, and 200 nM, respectively). It decreases adenosine A1 receptor-mediated adenosine-induced bradycardia in rats (ED50 = 0.49 mg/kg) but reduces A2 receptor-mediated adenosine-induced hypotension by only 44.6% when administered at an intravenous dose of 5 mg/kg. It prevents increases in heart levels of collagen I and III in nephrectomized rats when administered at a dose of 10 mg/kg per day. Derenofylline also reduces relative plaque counts in a Zika virus plaque-forming assay in A549 cells (IC50 = 58.6 nM) in an adenosine A1 receptor-independent manner without inducing cytotoxicity when used at concentrations less than 10 μM.

Uses

SLV 320 is an A1 antagonist.

in vivo

Derenofylline (0.3-10 mg/kg, oral administration) suppresses adenosine-induced bradycardia in rats[1].
Derenofylline (10 mg/kg/d, oral administration, 12 weeks) reduces myocardial fibrosis in 5/6 nephrectomy rats without affecting blood pressure[1].
Derenofylline (0.1-5mg/kg, intravenous injection) causes no major haemodynamic effects (heart rate and blood pressure)[1].

Animal Model:5/6 nephrectomy rats[1]
Dosage:10 mg/kg/d
Administration:Oral administration, mixed with food for 12 weeks
Result:Attenuated urinary albuminuria by about 50%.
Suppressed the increase in CK levels, ALT and AST plasma levels in nephrectomized animals.

IC 50

A1R: 1 nM (Ki); Adenosine A3 receptor: 200 nM (Ki); A2AR: 398 nM (Ki)

References

[1] P KALK. The adenosine A1 receptor antagonist SLV320 reduces myocardial fibrosis in rats with 5/6 nephrectomy without affecting blood pressure[J]. British Journal of Pharmacology, 2009, 151 7: 1025-1032. DOI: 10.1038/sj.bjp.0707319
[2] EWA D. MICEWICZ . Identification of novel small-molecule inhibitors of Zika virus infection[J]. Bioorganic & Medicinal Chemistry Letters, 2018, 28 3: Pages 452-458. DOI: 10.1016/j.bmcl.2017.12.019

Slv320 Preparation Products And Raw materials

Raw materials

Preparation Products

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Slv320 Suppliers

China 47 United Kingdom 1 United States 11 USA 1 Global 60
3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Fax
86-21-50328109
Email
3bsc@sina.com
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China
ProdList
15838
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EMMX Biotechnology LLC
Tel
888-539-0666
Fax
888-539-0666
Email
info@emmx.com
Country
United States
ProdList
8447
Advantage
60
Shanghai EFE Biological Technology Co., Ltd.
Tel
021-65675885 18964387627
Fax
021-65675885
Email
info@efebio.com
Country
China
ProdList
9803
Advantage
58
Shanghai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847; 18021002903
Fax
QQ:3008007432
Email
3008007409@qq.com
Country
China
ProdList
71826
Advantage
60
Tianjin Kailiqi Biotechnology Co., Ltd.
Tel
15076683720
Fax
022-23754520
Email
klq@cw-bio.com
Country
China
ProdList
8011
Advantage
55
Shanghai Chaolan Chemical Technology Center
Tel
021-QQ：65489617 15618227136
Fax
21-5161 9052
Email
Sales@ATKchemical.com
Country
China
ProdList
9125
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Jiangsu aikang biomedical research and development co., LTD
Tel
025-58859352 13155353615
Email
qzhang@aikonchem.com
Country
China
ProdList
15525
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TargetMol Chemicals Inc.
Tel
+1-781-999-5354; +17819995354
Email
marketing@targetmol.com
Country
United States
ProdList
32435
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58
Career Henan Chemica Co
Tel
+86-0371-86658258 +8613203830695
Fax
0371-86658258
Email
laboratory@coreychem.com
Country
China
ProdList
30229
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58
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
Tel
18818260767
Fax
QQ 3610331285
Email
sales@chemegen.com
Country
China
ProdList
11218
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58

251945-92-3, Slv320Related Search:


  • Cyclohexanol, 4-((2-phenyl-1H-pyrrolo(2,3-D)pyrimidin-4-yl)amino)-, trans-
  • Slv320
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  • (1R,4R)-4-(2-Phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)cyclohexanol
  • SC-204288
  • Derenofylline
  • 4-[(2-phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]cyclohexanol
  • SLV320; SLV-320; SLV 320; DERENOFYLLINE
  • Cyclohexanol, 4-[(2-phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]-, trans-
  • SLV320 >=98% (HPLC)
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  • Inhibitor,P1 receptor,Derenofylline,Adenosine Receptor,SLV320,fibrosis,uraemic,SLV-320,cardiomyopathy,SLV 320,inhibit,Nephrectomy
  • 4-[(2-phenyl-7H-pyrrolo[2， 3-d]pyrimidin-4-yl)amino]cyclohexan-1-ol
  • Derenofylline, 10 mM in DMSO
  • 251945-92-3