Slv320 Property

Boiling point:

532.3±60.0 °C(Predicted)

Density 

1.37±0.1 g/cm3(Predicted)

storage temp. 

Keep in dark place,Sealed in dry,2-8°C

solubility 

Soluble to 100 mM in DMSO and to 50 mM in ethanol

form 

Powder

pka

15.15±0.40(Predicted)

color 

White to off-white

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Slv320 Chemical Properties,Usage,Production

Description

Derenofylline is an adenosine A₁ receptor antagonist (K_i = 1 nM). It is selective for adenosine A₁ over A_2A, A_2B, and A₃ receptors (K_is = 398, 3,981, and 200 nM, respectively). It decreases adenosine A₁ receptor-mediated adenosine-induced bradycardia in rats (ED₅₀ = 0.49 mg/kg) but reduces A₂ receptor-mediated adenosine-induced hypotension by only 44.6% when administered at an intravenous dose of 5 mg/kg. It prevents increases in heart levels of collagen I and III in nephrectomized rats when administered at a dose of 10 mg/kg per day. Derenofylline also reduces relative plaque counts in a Zika virus plaque-forming assay in A549 cells (IC₅₀ = 58.6 nM) in an adenosine A₁ receptor-independent manner without inducing cytotoxicity when used at concentrations less than 10 μM.

Uses

SLV 320 is an A1 antagonist.