Unii-na83F1sjsr
- Product Name
- Unii-na83F1sjsr
- CAS No.
- 706782-28-7
- Chemical Name
- Unii-na83F1sjsr
- Synonyms
- PiMavanserin Tartrate;Nuplazid;ACP-103;BVF-048;Unii-na83F1sjsr;ACP-103 tartrate;8-Octanedioic acid;Pimavanserin tartrare;Pimavanserin tartrate vv;Pimavanserin L-Hetartrate
- CBNumber
- CB32494118
- Molecular Formula
- C29H40FN3O8
- Formula Weight
- 577.65
- MOL File
- 706782-28-7.mol
Unii-na83F1sjsr Property
- storage temp.
- Store at -20°C
- solubility
- DMSO:70.0(Max Conc. mg/mL);69.6(Max Conc. mM)
- form
- Solid
- color
- White to off-white
Safety
- HS Code
- 29299090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H317May cause an allergic skin reaction
H318Causes serious eye damage
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P272Contaminated work clothing should not be allowed out of the workplace.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P310Immediately call a POISON CENTER or doctor/physician.
P321Specific treatment (see … on this label).
P333+P313IF SKIN irritation or rash occurs: Get medical advice/attention.
P363Wash contaminated clothing before reuse.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- P441810
- Product name
- PimavanserinTartrate
- Packaging
- 5mg
- Price
- $160
- Updated
- 2021/12/16
- Product number
- 4806BB
- Product name
- Pimavanserintartrate
- Packaging
- 10mg
- Price
- $164
- Updated
- 2021/12/16
- Product number
- BP164269
- Product name
- Pimavanserin tartrate
- Packaging
- 50mg
- Price
- $297.5
- Updated
- 2021/12/16
- Product number
- CS-7954
- Product name
- Pimavanserintartrate
- Purity
- 99.47%
- Packaging
- 25mg
- Price
- $50
- Updated
- 2021/12/16
- Product number
- CS-7954
- Product name
- Pimavanserintartrate
- Purity
- 99.47%
- Packaging
- 50mg
- Price
- $80
- Updated
- 2021/12/16
Unii-na83F1sjsr Chemical Properties,Usage,Production
Description
Pimavanserin, developed by San Diego-based Acadia Pharmaceuticals, is a selective and potent serotonin 2A (5-HT2A) receptor inverse agonist. The USFDA approved this once-daily drug to treat the delusions and hallucinations associated with psychosis as a function of Parkinson’s disease. Pimavanserin has a unique mechanism of action relative to other antipsychotics, behaving as a selective inverse agonist of the serotonin 5-HT2A receptor while exhibiting 40-fold selectivity over the 5-HT2C receptor and having no significant affinity or activity with the 5-HT2B or dopamine receptors.
Uses
Pimavanserin tartrate is a 5-HT2A inverse agonist that reverses psychosis-like behaviours and has the potential to treat various other neuropsychiatric disorders such as schizophrenia and Parkinson’s disease.
Definition
ChEBI: A tartrate salt that is the hemitartrate salt of pimavanserin. An atypical antipsychotic that is used for treatment of hallucinations and delusions associated with Parkinson's disease.
Synthesis
Three patent applications filed by Acadia described the process-scale synthetic approach to pimavanserin. The kilogram-scale synthesis began with the alkylation of commercially available 4-hydroxybenzaldehyde (123) with isobutyl bromide (124) under basic conditions. Condensation of the resultant benzaldehyde 125 with hydroxylamine furnished the corresponding oxime 126 in 63% yield from 123. Hydrogenation of 126 catalyzed by Pd/C under acidic conditions produced benzylamine 127, which was isolated as the acetate salt in 41% yield. This compound underwent sodium hydroxide workup followed by reaction with HCl gas and phosgene to deliver isocyanate 128. Nucleophilic attack of this isocyanate by benzylamine 129 (prepared from reductive amination of commercially available N-methylpiperid-4-one 130 with 4-fluorobenzylamine 131) followed by salt formation using tartaric acid in aqueous isopropyl acetate, and THF completed the synthesis of pimavanserin tartrate (XI) in 50% yield over the two-step protocol and a 10.6% overall yield from 123.
Unii-na83F1sjsr Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Unii-na83F1sjsr manufacturers
- Product
- Pimavanserin Tartrate 706782-28-7
- Price
- US $0.00/g
- Min. Order
- 1g
- Purity
- More Than 99%
- Supply Ability
- 100kg/Month
- Release date
- 2024-09-20
- Product
- Pimavanserin Impurity reference 706782-28-7
- Price
- US $0.00/mg
- Min. Order
- 10mg
- Purity
- 0.98
- Supply Ability
- 10g
- Release date
- 2024-03-27
- Product
- Pimavanserin Tartrate 706782-28-7
- Price
- US $0.00-0.00/g
- Min. Order
- 1g
- Purity
- 98%
- Supply Ability
- 100kg
- Release date
- 2023-07-04