5-Trifluoromethylpyridine-3-boronic acid pinacol ester

Application

Product Name: 5-Trifluoromethylpyridine-3-boronic acid pinacol ester
CAS No.: 1084953-47-8
Chemical Name: 5-Trifluoromethylpyridine-3-boronic acid pinacol ester
Synonyms: 5-trifluoromethylpyridine-3-borate;5-Trifluoromethylpyridine-3-boronic acid picol ester;5-Trifluoromethylpyridine-3-boronic acid pinacol ester;[5-TRIFLUOROMETHYLPYRIDINE-3-BORONIC ACID PICOL ESTER];5-(Trifluoromethyl)pyridine-3-boronic acid, pinacol ester 98%;5-Trifluoromethylpyridine-3-boronic acid pinacol ester - [T10602];3-(tetramethyl-1,3,2-dioxaborolan-2-yl)-5-(trifluoromethyl)pyridine;3-(trifluoromethyl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine;Pyridine, 3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-5-(trifluoromethyl)-;3-hydroxy-2,3-dimethylbutan-2-yl hydrogen (5-(trifluoromethyl)pyridin-3-yl)boronate
CBNumber: CB32499719
Molecular Formula: C12H15BF3NO2
Formula Weight: 273.06
MOL File: 1084953-47-8.mol

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5-Trifluoromethylpyridine-3-boronic acid pinacol ester Property

Boiling point:: 313.6±42.0 °C(Predicted)
Density: 1.18±0.1 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
pka: 2.80±0.22(Predicted)
Appearance: White to off-white Solid
InChI: InChI=1S/C12H15BF3NO2/c1-10(2)11(3,4)19-13(18-10)9-5-8(6-17-7-9)12(14,15)16/h5-7H,1-4H3
InChIKey: LFZDWNHGQKQVIG-UHFFFAOYSA-N
SMILES: C1=NC=C(C(F)(F)F)C=C1B1OC(C)(C)C(C)(C)O1

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Safety

HS Code: 2933399990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

TRC

Product number: T889993
Product name: 3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-5-(trifluoromethyl)pyridine
Packaging: 100mg
Price: $65
Updated: 2021/12/16

SynQuest Laboratories

Product number: 8H60-3-Y7
Product name: 5-(Trifluoromethyl)pyridine-3-boronic acid, pinacol ester
Packaging: 250mg
Price: $85
Updated: 2021/12/16

ChemScene

Product number: CS-W005560
Product name: 3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-5-(trifluoromethyl)pyridine
Purity: >98.0%
Packaging: 1g
Price: $93
Updated: 2021/12/16

Synthonix

Product number: T10602
Product name: 5-Trifluoromethylpyridine-3-boronicacidpinacolester
Purity: 97.0%
Packaging: 1g
Price: $120
Updated: 2021/12/16

Apolloscientific

Product number: PC49119
Product name: 5-(Trifluoromethyl)pyridine-3-boronicacid,pinacolester
Purity: 98%
Packaging: 1g
Price: $132
Updated: 2021/12/16

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5-Trifluoromethylpyridine-3-boronic acid pinacol ester Chemical Properties,Usage,Production

Application

5-Trifluoromethylpyridine-3-boronic acid pinacol ester can be used as an organic synthesis intermediate and a pharmaceutical intermediate, mainly in laboratory research and development and chemical production processes.

Synthesis

73183-34-3

436799-33-6

1084953-47-8

The general procedure for the synthesis of 5-trifluoromethylpyridine-3-boronic acid pinacol ester from pinacol ester of biphenylboronic acid and 3-bromo-5-(trifluoromethyl)pyridine was as follows: 3.50 g (15.50 mmol) of 3-bromo-5-(trifluoromethyl)pyridine, 0.54 g (0.8 mmol) of bis(triphenylphosphine)palladium(II) chloride and 4.55 g (46.5 mmol) of potassium acetate were suspended in 75 mL of dioxane and stirred for 15 minutes. Subsequently, 6.42 g (24.8 mmol) of pinacol ester of bisboronic acid (4,4,5,5,4',4',5',5'-octamethyl-[2,2']bis[[1,3,2]dioxaborolane]) was added and the mixture was heated to 100 °C for 20 hours of reaction. Upon completion of the reaction, the mixture was poured into crushed ice, the pH was adjusted to 9-10 with sodium carbonate solution, and then extracted three times with ethyl acetate. The organic phases were combined, washed with water, dried over magnesium sulfate, filtered and concentrated. The residue was purified by fast column chromatography (dichloromethane/methanol, 1:0 to 9:1) to give 3.48 g (82% yield) of 5-trifluoromethylpyridine-3-boronic acid pinacol ester as a colorless solid. Mass spectrum (MS): 273.1 (M+).

References

[1] Patent: US2009/48238, 2009, A1. Location in patent: Page/Page column 20
[2] Patent: WO2013/43521, 2013, A1. Location in patent: Page/Page column 38; 39
[3] Patent: EP2719697, 2014, A1. Location in patent: Paragraph 0210-0212
[4] Patent: EP2891656, 2015, A1. Location in patent: Paragraph 0266

5-Trifluoromethylpyridine-3-boronic acid pinacol ester Preparation Products And Raw materials

Raw materials

Preparation Products

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5-Trifluoromethylpyridine-3-boronic acid pinacol ester Suppliers

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View Lastest Price from 5-Trifluoromethylpyridine-3-boronic acid pinacol ester manufacturers

Zhuozhou Wenxi import and Export Co., Ltd

Product: 5-Trifluoromethylpyridine-3-boronic acid pinacol ester 1084953-47-8
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-10

Zhuozhou Wenxi import and Export Co., Ltd

Product: 5-Trifluoromethylpyridine-3-boronic acid pinacol ester 1084953-47-8
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-09

Career Henan Chemical Co

Product: 5-Trifluoromethylpyridine-3-boronic acid pinacol ester 1084953-47-8
Price: US $1.00/KG
Min. Order: 1KG
Purity: 95%
Supply Ability: 500KG
Release date: 2018-08-19

1084953-47-8, 5-Trifluoromethylpyridine-3-boronic acid pinacol esterRelated Search:

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5-Trifluoromethylpyridine-3-boronic acid pinacol ester - [T10602]

1084953-47-8