5-(TRIFLUOROMETHYL)NICOTINONITRILE

Product Name: 5-(TRIFLUOROMETHYL)NICOTINONITRILE
CAS No.: 951624-83-2
Chemical Name: 5-(TRIFLUOROMETHYL)NICOTINONITRILE
Synonyms: 5-(TRIFLUOROMETHYL)NICOTINONITRILE;3-Cyano-5-(trifluoromethyl)-pyridine;5-(Trifluoromethyl)nicotinonitrile, 95+%;5-(Trifluoromethyl)-3-pyridinecarbonitrile;3-Pyridinecarbonitrile, 5-(trifluoroMethyl)-;5-(Trifluoromethyl)pyridine-3-carbonitrile ;5-(Trifluoromethyl)pyridine-3-carbonitrile, CAS 951624-83-2
CBNumber: CB1815108
Molecular Formula: C7H3F3N2
Formula Weight: 172.11
MOL File: 951624-83-2.mol

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5-(TRIFLUOROMETHYL)NICOTINONITRILE Property

Melting point:: 46-47°C
Boiling point:: 204.4±35.0 °C(Predicted)
Density: 1.37±0.1 g/cm3(Predicted)
Flash point:: 82℃
storage temp.: Inert atmosphere,Room Temperature
form: solid
pka: -0?+-.0.20(Predicted)
Appearance: White to off-white Solid

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Safety

Hazard Codes: Xi,T
Risk Statements: 25-37/38-41
Safety Statements: 7/9-22-24/25-26-36/37/39-45-51
RIDADR: UN 2811 6.1 / PGIII
WGK Germany: 3
HazardClass: IRRITANT
HS Code: 2933399990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H301Toxic if swalloed

H315Causes skin irritation

H318Causes serious eye damage

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 708151
Product name: 5-(Trifluoromethyl)pyridine-3-carbonitrile
Purity: 95%
Packaging: 250mg
Price: $19.18
Updated: 2025/07/31

TRC

Product number: T797148
Product name: 5-(Trifluoromethyl)nicotinonitrile
Packaging: 500mg
Price: $175
Updated: 2021/12/16

Matrix Scientific

Product number: 023804
Product name: 5-(Trifluoromethyl)nicotinonitrile
Purity: 95%
Packaging: 500mg
Price: $97
Updated: 2021/12/16

Apolloscientific

Product number: PC520548
Product name: 5-(Trifluoromethyl)nicotinonitrile
Packaging: 1g
Price: $100
Updated: 2021/12/16

AK Scientific

Product number: Y4824
Product name: 5-(Trifluoromethyl)nicotinonitrile
Packaging: 250mg
Price: $144
Updated: 2021/12/16

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5-(TRIFLUOROMETHYL)NICOTINONITRILE Chemical Properties,Usage,Production

Synthesis

557-21-1

436799-33-6

951624-83-2

Example 1.1.27: Synthesis of (5-(trifluoromethyl)pyridin-3-yl)methanamine: 3-bromo-5-(trifluoromethyl)pyridine (1.0 g, 4.42 mmol, 1 eq.) was dissolved in 20 mL of anhydrous DMF. The solution was degassed by argon bubbling. Zinc cyanide (Zn(CN)2, 0.312 g, 2.65 mmol, 0.6 eq.) and tetrakis(triphenylphosphine)palladium (Pd(PPh3)4) were subsequently added and the resulting reaction mixture was heated to 80 °C and stirred overnight. Upon completion of the reaction, the mixture was cooled to room temperature and diluted with ether (Et2O). The organic and aqueous layers were separated by adding 28% ammonia (NH4OH) with continuous stirring. The organic layer was sequentially washed three times with water, once with brine and dried with anhydrous sodium sulfate (Na2SO4). After filtration to remove inorganic salts, the filtrate was concentrated under reduced pressure. Finally, it was purified by silica gel fast column chromatography to obtain 5-(trifluoromethyl)nicotinonitrile (0.310 g, 1.95 mmol, 44% yield).

References

[1] Patent: WO2009/42694, 2009, A1. Location in patent: Page/Page column 84

5-(TRIFLUOROMETHYL)NICOTINONITRILE Preparation Products And Raw materials

Raw materials

Preparation Products

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5-(TRIFLUOROMETHYL)NICOTINONITRILE Suppliers

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View Lastest Price from 5-(TRIFLUOROMETHYL)NICOTINONITRILE manufacturers

Career Henan Chemical Co

Product: 3-Pyridinecarbonitrile,5-(trifluoromethyl)- 951624-83-2
Price: US $9.80/KG
Min. Order: 1KG
Purity: ≥98%
Supply Ability: 20 tons
Release date: 2020-01-09

951624-83-2, 5-(TRIFLUOROMETHYL)NICOTINONITRILERelated Search:

5-(Trifluoromethyl)pyridin-2-amine 4-Trifluoromethyl-pyridine-2-carbonitrile 4-(Trifluoromethyl)nicotinonitrile 5-(Trifluoromethyl)pyridine-2-carboxylic acid 4-Amino-3-(trifluoromethyl)pyridine 5-Trifluoromethyl-pyridin-3-ylamine 4-Bromo-3-(trifluoromethyl)pyridine 3-(TRIFLUOROMETHYL)ISONICOTINIC ACID 2-Bromo-4-(trifluoromethyl)pyridine 3-Bromo-5-(trifluoromethyl)pyridine 4-(TRIFLUOROMETHYL)PYRIDINE-2-CARBOXYLIC ACID 4-(Trifluoromethyl)nicotinic acid 3-Bromo-4-trifluoromethylpyridine 2-Chloro-5-trifluoromethyl-nicotinonitrile 6-METHOXY-5-(TRIFLUOROMETHYL)-3-PYRIDINECARBONITRILE 3-METHYL-5-(TRIFLUOROMETHYL)PYRIDINE 5-(TRIFLUOROMETHYL)NICOTINONITRILE 2-hydroxy-5-trifluoromethyl-nicotinonitrile

5-(TRIFLUOROMETHYL)NICOTINONITRILE

5-(Trifluoromethyl)nicotinonitrile, 95+%

3-Pyridinecarbonitrile, 5-(trifluoroMethyl)-

5-(Trifluoromethyl)pyridine-3-carbonitrile

3-Cyano-5-(trifluoromethyl)-pyridine

5-(Trifluoromethyl)-3-pyridinecarbonitrile

5-(Trifluoromethyl)pyridine-3-carbonitrile, CAS 951624-83-2

951624-83-2