5-Trifluoromethyl-pyridin-3-ylamine

Product Name: 5-Trifluoromethyl-pyridin-3-ylamine
CAS No.: 112110-07-3
Chemical Name: 5-Trifluoromethyl-pyridin-3-ylamine
Synonyms: 5-(TrifluoroMethyl)pyridin-3-aMine;5-(Trifluoromethyl)-3-pyridinamine;3-Amino-5-trifluoromethyl-pyridine;3-Pyridinamine,5-(trifluoromethyl);5-(TrifluorMethyl)-3-aMinopyridine;5-Trifluoromethyl-pyridin-3-ylamine;5-Trifluoromethyl-pyridin-3-ylamine ISO 9001：2015 REACH
CBNumber: CB41560086
Molecular Formula: C6H5F3N2
Formula Weight: 162.11
MOL File: 112110-07-3.mol

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5-Trifluoromethyl-pyridin-3-ylamine Property

Melting point:: 40-41.5 °C
Boiling point:: 105.5-106 °C(Press: 11 Torr)
Density: 1.368
storage temp.: under inert gas (nitrogen or Argon) at 2–8 °C
pka: 3.74±0.20(Predicted)
Appearance: Colorless to light yellow <40°C Solid,>41.5°C Liquid
InChI: InChI=1S/C6H5F3N2/c7-6(8,9)4-1-5(10)3-11-2-4/h1-3H,10H2
InChIKey: NJFRBMFEAGFNDC-UHFFFAOYSA-N
SMILES: C1=NC=C(C(F)(F)F)C=C1N

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Safety

RIDADR: UN2811
HS Code: 2933399990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P310Immediately call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

TRC

Product number: T797238
Product name: 5-(Trifluoromethyl)pyridin-3-amine
Packaging: 50mg
Price: $60
Updated: 2021/12/16

SynQuest Laboratories

Product number: 3H30-3-80
Product name: 5-(Trifluoromethyl)pyridin-3-amine
Purity: 97%
Packaging: 1g
Price: $100
Updated: 2021/12/16

Apolloscientific

Product number: PC301200
Product name: 3-Amino-5-(trifluoromethyl)pyridine
Packaging: 1g
Price: $143
Updated: 2021/12/16

Matrix Scientific

Product number: 073977
Product name: 5-(Trifluoromethyl)-3-aminopyridine
Purity: 95+%
Packaging: 1g
Price: $328
Updated: 2021/12/16

Apolloscientific

Product number: PC301200
Product name: 3-Amino-5-(trifluoromethyl)pyridine
Packaging: 5g
Price: $340
Updated: 2021/12/16

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5-Trifluoromethyl-pyridin-3-ylamine Chemical Properties,Usage,Production

Synthesis

72587-15-6

112110-07-3

Step Ia: 5-(Trifluoromethyl)-2-chloro-3-nitropyridine (0.850 g, 3.75 mmol) was dissolved in methanol (17 mL), and palladium carbon (800 mg, 10% wetted, 0.375 mmol) was added. The reaction mixture was hydrogenated for 16 h at 60 psi hydrogen pressure and 20 °C. The progress of the reaction was monitored by LCMS to confirm that the starting material (M + H 213/215, 3:1) and hydroxylamine intermediate were completely consumed and a mixture of partially reduced product (M + H 163; UVmax 214, 258, 332 nm) and completely reduced product (M + H 169; no UV absorption) was detected. After completion of the reaction, the reaction mixture was filtered and the filter cake was washed well with methanol. The filtrate was concentrated in vacuum to give 0.74 g of product in the form of HCl salt. Subsequently, the product was purified by preparative HPLC/MS using a 30 mm × 100 mm C18 column; the mobile phase was 20% acetonitrile-water (containing 0.1% NH4OH), with an initial hold of 1 min and a gradient up to 40% over 6 min; the flow rate was 60 mL/min; the detector was set at m/z 163; and the product retention time was 4.4 min. Fractions containing the pure product were collected, combined and concentrated to give 52 mg of the product as an oil in 8% yield.1H NMR (CDCl3) δ 8.26 (s, 1H); 8.24 (d, 1H); 7.15 (t, 1H); 4.00 (s, 2H).

References

[1] Patent: WO2008/79965, 2008, A1. Location in patent: Page/Page column 72-73
[2] Patent: US2006/4018, 2006, A1. Location in patent: Page/Page column 14; 35-36

5-Trifluoromethyl-pyridin-3-ylamine Preparation Products And Raw materials

Raw materials

Preparation Products

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5-Trifluoromethyl-pyridin-3-ylamine Suppliers

Canada 2 China 131 India 2 United Kingdom 1 United States 13 Global 149

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Jinan Trio PharmaTech Co., Ltd.

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View Lastest Price from 5-Trifluoromethyl-pyridin-3-ylamine manufacturers

Henan Aochuang Chemical Co.,Ltd.

Product: 5-Trifluoromethyl-pyridin-3-ylamine 112110-07-3
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-09-29

Dideu Industries Group Limited

Product: 5-Trifluoromethyl-pyridin-3-ylamine 112110-07-3
Price: US $1.10/g
Min. Order: 1g
Purity: 99.00%
Supply Ability: 100 Tons min
Release date: 2021-08-27

Career Henan Chemical Co

Product: 5-Trifluoromethyl-pyridin-3-ylamine 112110-07-3
Price: US $6.60/KG
Min. Order: 1KG
Purity: 97%-99%
Supply Ability: 1kg -1000kg
Release date: 2020-01-02

112110-07-3, 5-Trifluoromethyl-pyridin-3-ylamineRelated Search:

2-METHYLAMINO-3-NITRO-5-(TRIFLUOROMETHYL)PYRIDINE 2-HYDROXY-5-NITRO-3-(TRIFLUOROMETHYL)PYRIDINE 5-Trifluoromethyl-pyridin-3-ylamine 3-AMINO-2-(METHYLAMINO)-5-(TRIFLUOROMETHYL)PYRIDINE 3-(4-CHLOROPHENYL)-8-(TRIFLUOROMETHYL)PYRIDO[2,3-E][1,2,3]TRIAZOLO[1,5-A]PYRIMIDIN-5-AMINE 3-AZIDO-5-(TRIFLUOROMETHYL)-2-PYRIDINECARBONITRILE 3-(3,4-DIMETHOXYPHENYL)-8-(TRIFLUOROMETHYL)PYRIDO[2,3-E][1,2,3]TRIAZOLO[1,5-A]PYRIMIDIN-5-AMINE 3-(1-METHYL-1H-PYRROL-2-YL)-8-(TRIFLUOROMETHYL)PYRIDO[2,3-E][1,2,3]TRIAZOLO[1,5-A]PYRIMIDIN-5-AMINE 3-(2,4-DICHLOROPHENYL)-8-(TRIFLUOROMETHYL)PYRIDO[2,3-E][1,2,3]TRIAZOLO[1,5-A]PYRIMIDIN-5-AMINE [3-(DIMETHYLAMINO)-5-(TRIFLUOROMETHYL)-2-PYRIDINYL](PHENYL)METHANONE N1-[6-CHLORO-5-(TRIFLUOROMETHYL)-3-PYRIDYL]CYCLOPROPANE-1-CARBOXAMIDE 3-PHENYL-8-(TRIFLUOROMETHYL)PYRIDO[2,3-E][1,2,3]TRIAZOLO[1,5-A]PYRIMIDIN-5-AMINE 5-AMINO-8-(TRIFLUOROMETHYL)PYRIDO[2,3-E][1,2,3]TRIAZOLO[1,5-A]PYRIMIDINE-3-CARBOXAMIDE [3-MORPHOLINO-5-(TRIFLUOROMETHYL)-2-PYRIDINYL](4-NITROPHENYL)METHANONE 3-(4-ACETYL-5-METHYL-1H-1,2,3-TRIAZOL-1-YL)-5-(TRIFLUOROMETHYL)-2-PYRIDINECARBONITRILE [3-(4-METHYLPIPERAZINO)-5-(TRIFLUOROMETHYL)-2-PYRIDINYL](4-NITROPHENYL)METHANONE 5-AMINO-8-(TRIFLUOROMETHYL)PYRIDO[2,3-E][1,2,3]TRIAZOLO[1,5-A]PYRIMIDINE-3-CARBONITRILE (4-CHLOROPHENYL)[3-(DIMETHYLAMINO)-5-(TRIFLUOROMETHYL)-2-PYRIDINYL]METHANONE

5-Trifluoromethyl-pyridin-3-ylamine

5-(Trifluoromethyl)-3-pyridinamine

5-(TrifluorMethyl)-3-aMinopyridine

5-(TrifluoroMethyl)pyridin-3-aMine

3-Pyridinamine,5-(trifluoromethyl)

3-Amino-5-trifluoromethyl-pyridine

5-Trifluoromethyl-pyridin-3-ylamine ISO 9001：2015 REACH

112110-07-3

74784-70-7

Fluorine series