ChemicalBook > CAS DataBase List > 5-Trifluoromethyl-pyridin-3-ylamine

5-Trifluoromethyl-pyridin-3-ylamine

Product Name
5-Trifluoromethyl-pyridin-3-ylamine
CAS No.
112110-07-3
Chemical Name
5-Trifluoromethyl-pyridin-3-ylamine
Synonyms
5-(TrifluoroMethyl)pyridin-3-aMine;5-(Trifluoromethyl)-3-pyridinamine;3-Amino-5-trifluoromethyl-pyridine;3-Pyridinamine,5-(trifluoromethyl);5-(TrifluorMethyl)-3-aMinopyridine;5-Trifluoromethyl-pyridin-3-ylamine;5-Trifluoromethyl-pyridin-3-ylamine ISO 9001：2015 REACH
CBNumber
CB41560086
Molecular Formula
C6H5F3N2
Formula Weight
162.11
MOL File
112110-07-3.mol
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5-Trifluoromethyl-pyridin-3-ylamine Property

Melting point:
40-41.5 °C
Boiling point:
105.5-106 °C(Press: 11 Torr)
Density 
1.368
storage temp. 
under inert gas (nitrogen or Argon) at 2–8 °C
pka
3.74±0.20(Predicted)
Appearance
Colorless to light yellow <40°C Solid,>41.5°C Liquid
InChI
InChI=1S/C6H5F3N2/c7-6(8,9)4-1-5(10)3-11-2-4/h1-3H,10H2
InChIKey
NJFRBMFEAGFNDC-UHFFFAOYSA-N
SMILES
C1=NC=C(C(F)(F)F)C=C1N
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Safety

RIDADR 
UN2811
HS Code 
2933399990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P310Immediately call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

TRC
Product number
T797238
Product name
5-(Trifluoromethyl)pyridin-3-amine
Packaging
50mg
Price
$60
Updated
2021/12/16
SynQuest Laboratories
Product number
3H30-3-80
Product name
5-(Trifluoromethyl)pyridin-3-amine
Purity
97%
Packaging
1g
Price
$100
Updated
2021/12/16
Apolloscientific
Product number
PC301200
Product name
3-Amino-5-(trifluoromethyl)pyridine
Packaging
1g
Price
$143
Updated
2021/12/16
Matrix Scientific
Product number
073977
Product name
5-(Trifluoromethyl)-3-aminopyridine
Purity
95+%
Packaging
1g
Price
$328
Updated
2021/12/16
Apolloscientific
Product number
PC301200
Product name
3-Amino-5-(trifluoromethyl)pyridine
Packaging
5g
Price
$340
Updated
2021/12/16
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5-Trifluoromethyl-pyridin-3-ylamine Chemical Properties,Usage,Production

Synthesis

72587-15-6

112110-07-3

Step Ia: 5-(Trifluoromethyl)-2-chloro-3-nitropyridine (0.850 g, 3.75 mmol) was dissolved in methanol (17 mL), and palladium carbon (800 mg, 10% wetted, 0.375 mmol) was added. The reaction mixture was hydrogenated for 16 h at 60 psi hydrogen pressure and 20 °C. The progress of the reaction was monitored by LCMS to confirm that the starting material (M + H 213/215, 3:1) and hydroxylamine intermediate were completely consumed and a mixture of partially reduced product (M + H 163; UVmax 214, 258, 332 nm) and completely reduced product (M + H 169; no UV absorption) was detected. After completion of the reaction, the reaction mixture was filtered and the filter cake was washed well with methanol. The filtrate was concentrated in vacuum to give 0.74 g of product in the form of HCl salt. Subsequently, the product was purified by preparative HPLC/MS using a 30 mm × 100 mm C18 column; the mobile phase was 20% acetonitrile-water (containing 0.1% NH4OH), with an initial hold of 1 min and a gradient up to 40% over 6 min; the flow rate was 60 mL/min; the detector was set at m/z 163; and the product retention time was 4.4 min. Fractions containing the pure product were collected, combined and concentrated to give 52 mg of the product as an oil in 8% yield.1H NMR (CDCl3) δ 8.26 (s, 1H); 8.24 (d, 1H); 7.15 (t, 1H); 4.00 (s, 2H).

References

[1] Patent: WO2008/79965, 2008, A1. Location in patent: Page/Page column 72-73
[2] Patent: US2006/4018, 2006, A1. Location in patent: Page/Page column 14; 35-36

5-Trifluoromethyl-pyridin-3-ylamine Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 5-Trifluoromethyl-pyridin-3-ylamine manufacturers

Henan Aochuang Chemical Co.,Ltd.
Product
5-Trifluoromethyl-pyridin-3-ylamine 112110-07-3
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1Ton
Release date
2022-09-29
Dideu Industries Group Limited
Product
5-Trifluoromethyl-pyridin-3-ylamine 112110-07-3
Price
US $1.10/g
Min. Order
1g
Purity
99.00%
Supply Ability
100 Tons min
Release date
2021-08-27
Career Henan Chemical Co
Product
5-Trifluoromethyl-pyridin-3-ylamine 112110-07-3
Price
US $6.60/KG
Min. Order
1KG
Purity
97%-99%
Supply Ability
1kg -1000kg
Release date
2020-01-02

112110-07-3, 5-Trifluoromethyl-pyridin-3-ylamineRelated Search:

2-METHYLAMINO-3-NITRO-5-(TRIFLUOROMETHYL)PYRIDINE 2-HYDROXY-5-NITRO-3-(TRIFLUOROMETHYL)PYRIDINE 5-Trifluoromethyl-pyridin-3-ylamine 3-AMINO-2-(METHYLAMINO)-5-(TRIFLUOROMETHYL)PYRIDINE 3-(4-CHLOROPHENYL)-8-(TRIFLUOROMETHYL)PYRIDO[2,3-E][1,2,3]TRIAZOLO[1,5-A]PYRIMIDIN-5-AMINE 3-AZIDO-5-(TRIFLUOROMETHYL)-2-PYRIDINECARBONITRILE 3-(3,4-DIMETHOXYPHENYL)-8-(TRIFLUOROMETHYL)PYRIDO[2,3-E][1,2,3]TRIAZOLO[1,5-A]PYRIMIDIN-5-AMINE 3-(1-METHYL-1H-PYRROL-2-YL)-8-(TRIFLUOROMETHYL)PYRIDO[2,3-E][1,2,3]TRIAZOLO[1,5-A]PYRIMIDIN-5-AMINE 3-(2,4-DICHLOROPHENYL)-8-(TRIFLUOROMETHYL)PYRIDO[2,3-E][1,2,3]TRIAZOLO[1,5-A]PYRIMIDIN-5-AMINE [3-(DIMETHYLAMINO)-5-(TRIFLUOROMETHYL)-2-PYRIDINYL](PHENYL)METHANONE N1-[6-CHLORO-5-(TRIFLUOROMETHYL)-3-PYRIDYL]CYCLOPROPANE-1-CARBOXAMIDE 3-PHENYL-8-(TRIFLUOROMETHYL)PYRIDO[2,3-E][1,2,3]TRIAZOLO[1,5-A]PYRIMIDIN-5-AMINE 5-AMINO-8-(TRIFLUOROMETHYL)PYRIDO[2,3-E][1,2,3]TRIAZOLO[1,5-A]PYRIMIDINE-3-CARBOXAMIDE [3-MORPHOLINO-5-(TRIFLUOROMETHYL)-2-PYRIDINYL](4-NITROPHENYL)METHANONE 3-(4-ACETYL-5-METHYL-1H-1,2,3-TRIAZOL-1-YL)-5-(TRIFLUOROMETHYL)-2-PYRIDINECARBONITRILE [3-(4-METHYLPIPERAZINO)-5-(TRIFLUOROMETHYL)-2-PYRIDINYL](4-NITROPHENYL)METHANONE 5-AMINO-8-(TRIFLUOROMETHYL)PYRIDO[2,3-E][1,2,3]TRIAZOLO[1,5-A]PYRIMIDINE-3-CARBONITRILE (4-CHLOROPHENYL)[3-(DIMETHYLAMINO)-5-(TRIFLUOROMETHYL)-2-PYRIDINYL]METHANONE

  • 5-Trifluoromethyl-pyridin-3-ylamine
  • 5-(Trifluoromethyl)-3-pyridinamine
  • 5-(TrifluorMethyl)-3-aMinopyridine
  • 5-(TrifluoroMethyl)pyridin-3-aMine
  • 3-Pyridinamine,5-(trifluoromethyl)
  • 3-Amino-5-trifluoromethyl-pyridine
  • 5-Trifluoromethyl-pyridin-3-ylamine ISO 9001：2015 REACH
  • 112110-07-3
  • 74784-70-7
  • Fluorine series