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Sugammadex sodium

Product Name
Sugammadex sodium
CAS No.
343306-79-6
Chemical Name
Sugammadex sodium
Synonyms
ORG;Sugammadex Na;Sugammadex soidum;Sugammadex sodium iMpurity;6A,6B,6C,6D,6E,6F,6G,6H-octakis-S-(2-Carboxyethyl)-6A,6B,6C,6D,6E,6F,6G,6H-octathio-γ-cyclodextrin Sodium Salt;6A,6B,6C,6D,6E,6F,6G,6H-Octakis-S-(2-carboxyethyl)-6A,6B,6C,6D,6E,6F,6G-octasulfanyl-gamma-cyclodextrin octasodium salt;CS-2749;Suga-im D;madex Sodium;Sugammadex IMP
CBNumber
CB32502868
Molecular Formula
C72H104Na8O48S8
Formula Weight
2177.97
MOL File
343306-79-6.mol
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Sugammadex sodium Property

storage temp. 
Inert atmosphere,Room Temperature
solubility 
DMF: 2.5 mg/ml; DMSO: 2.5 mg/ml; DMSO:PBS (pH 7.2) (1:30): 0.03 mg/ml
form 
A crystalline solid
InChIKey
NIOBYNJFPSIMJF-OBHNVPISNA-N
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H302Harmful if swallowed

H334May cause allergy or asthma symptoms or breathing difficulties if inhaled

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P285In case of inadequate ventilation wear respiratory protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P304+P341IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.

P330Rinse mouth.

P342+P311IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML3224
Product name
Sugammadex sodium
Purity
≥95% (HPLC)
Packaging
25MG
Price
$109
Updated
2024/03/01
Sigma-Aldrich
Product number
SML3224
Product name
Sugammadex sodium
Purity
≥95% (HPLC)
Packaging
100MG
Price
$350
Updated
2024/03/01
Cayman Chemical
Product number
24096
Product name
Sugammadex (sodium salt)
Purity
≥98%
Packaging
1mg
Price
$32
Updated
2024/03/01
Cayman Chemical
Product number
24096
Product name
Sugammadex (sodium salt)
Purity
≥98%
Packaging
5mg
Price
$139
Updated
2024/03/01
Cayman Chemical
Product number
24096
Product name
Sugammadex (sodium salt)
Purity
≥98%
Packaging
10mg
Price
$243
Updated
2024/03/01
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Sugammadex sodium Chemical Properties,Usage,Production

Description

To facilitate tracheal intubation, mechanical ventilation, and surgical access, NMB agents are frequently used as non-anesthetic adjuncts in surgical procedures. Sugammadex is able to function as a pharmacologic sink of rocuronium and vecuronium, another non-depolarizing neuromuscular blocker, without the cardiovascular adverse effects experienced with reversal agents that directly interact with the cholinergic system. The γ-cyclodextrin has been designed to enhance binding of the guest by incorporating acidic side chains to promote an electrostatic interaction with the positive nitrogen of the blocker. Starting with γ-cyclodextrin, these side chains are readily installed by first halogenating with iodine or bromine to provide a handle for nucleophilic displacement with either 3-mercaptopropionic acid in the presence of sodium hydride or with 3-mercaptopropionic acid methyl ester and cesium carbonate. The latter requires hydrolysis with sodium hydroxide to generate sugammadex sodium.

Chemical Properties

White to Light yellow powder to crystal.Soluble in water, insoluble in methanol and ethanol.

Originator

Organon (Netherlands)

Uses

Sugammadex Sodium is the first in a class of drugs called selective relaxant binding agents that offers improved termination of the paralytic effects of neuromuscular blocking agents and may have many potential peri-operative benefits.

Application

Sugammadex sodium is a modified γ-cyclodextrin. It is a selective relaxant binding agent (SRBA) indicated for reversal of neuromuscular block induced by steroid-based muscle relaxants, such as rocuronium bromide and vecuronium bromide. Sugammadex soium forms a complex with the muscle relaxants, and it reduces the amount of them available to bind to nicotinic cholinergic receptors in the neuromuscular junction.

Definition

ChEBI: Sugammadex sodium is an organic sodium salt that is the octasodium salt of sugammadex. Used for reversal of neuromuscular blockade induced by rocuronium and vecuronium in adults undergoing surgery. It has a role as a neuromuscular agent. It contains a sugammadex(8-).

brand name

Bridion

Side effects

The most common adverse effects included coughing, movement, vomiting, dry mouth, dysgeusia, hypotension, parosmia, and a sensation of changed temperature.Sugammadex is recommended for the reversal of neuromuscular blockade induced by rocuronium or vecuronium; it should not be used with other steroidal blocking agents since safety and efficacy data are not available for these situations. It should also not be partnered with non-steroidal neuromuscular blockers such as succinylcholine or benzylisoquinolinium-based drugs. Since sugammadex is predominantly cleared by the kidneys, care should be taken when administering this reversal agent in patients with renal impairment.

Mode of action

Sugammadex Sodium is the sodium salt form of sugammadex, a biologically inert, selective relaxant binding agent (SRBA) composed of a modified, anionic gamma cyclodextrin derivative containing a hydrophilic exterior and a hydrophobic core, with neuromuscular blocking drug (NMBD) reversal activity. Upon administration, the negatively charged carboxyl-thio-ether groups of sugammadex selectively and reversibly bind to the positively charged quaternary nitrogen of a steroidal NMBD, such as rocuronium and vecuronium, which was administered at an earlier time for anesthetic purposes. The encapsulation of the NMBD by sugammadex blocks its ability to bind to nicotinic receptors in the neuromuscular junction and thereby reverses the NMBD-induced neuromuscular blockade.

Sugammadex sodium Preparation Products And Raw materials

Raw materials

Preparation Products

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Sugammadex sodium Suppliers

Beijing Sai Siyuan Biomedical Technology Co., Ltd.
Tel
010-87925700 13522399152
Email
1664478984@qq.com
Country
China
ProdList
10
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58
Shanghai Rechem science Co., Ltd.
Tel
21-31433387 15618786686
Fax
QQ:1369748377
Email
sales@rechemscience.com
Country
China
ProdList
2972
Advantage
58
Hubei Moco Chemical Co., Ltd.
Tel
18627756402
Fax
QQ:3001051413
Email
3001051413@qq.com
Country
China
ProdList
10001
Advantage
58
Guangzhou Dreampharm Biotechnology Co., Ltd.
Tel
17825480238
Fax
QQ 3008233717
Email
3008233717@qq.com
Country
China
ProdList
9844
Advantage
12
Suzhou Gopon Pharmaceutical Co., Ltd
Tel
133-5805-9751
Email
gopon2012@gmail.com
Country
China
ProdList
276
Advantage
58
Hangzhou Hua Zhe Biological Medicine Co., LTD
Tel
17302275155
Email
tanglulu1129@163.com
Country
China
ProdList
96
Advantage
58
BrightGene Bio-medical Technology Co., Ltd.
Tel
0512-0512-62551764 18013103761
Fax
0512-62551799
Email
sales01@bright-gene.com
Country
China
ProdList
61
Advantage
70
Nantong Xiaochang Pharmaceutical Trading Co., Ltd.
Tel
0513-82104991 15716298942
Fax
QQ1907456386
Email
sales2@btcpharm.com
Country
China
ProdList
1338
Advantage
58
Chengdu Dihe Yongxin Pharmaceutical Technology Co., Ltd
Tel
13928288528
Email
wangziyu@desano.com
Country
China
ProdList
196
Advantage
58
Shanghai Boyle Chemical Co., Ltd.
Tel
Fax
86-21-57758967
Email
sales@boylechem.com
Country
China
ProdList
2923
Advantage
55
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View Lastest Price from Sugammadex sodium manufacturers

PNP Biotech Co. Ltd
Product
Sugammadex sodium 343306-79-6
Price
US $0.00/KG
Min. Order
25KG
Purity
98%
Supply Ability
Inquiry
Release date
2022-10-18
Sinoway Industrial co., ltd.
Product
Sugammadex sodium 343306-79-6
Price
US $0.00/KG
Min. Order
2KG
Purity
99% up, High Density
Supply Ability
20 tons
Release date
2021-09-09
shandong perfect biotechnology co.ltd
Product
Sugammadex Sodium 343306-79-6
Price
US $0.00/g
Min. Order
1g
Purity
98% HPLC
Supply Ability
1kg
Release date
2023-08-03

343306-79-6, Sugammadex sodiumRelated Search:


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  • Sugammadex sodium iMpurity
  • 6A,6B,6C,6D,6E,6F,6G,6H-octakis-S-(2-Carboxyethyl)-6A,6B,6C,6D,6E,6F,6G,6H-octathio-γ-cyclodextrin Sodium Salt
  • Sugammadex Sodium salt
  • 6A,6B,6C,6D,6E,6F,6G,6H-Octakis-S-(2-carboxyethyl)-6A,6B,6C,6D,6E,6F,6G-octasulfanyl-gamma-cyclodextrin octasodium salt
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  • 343306-79-6
  • 43306-79-6
  • C72H104Na8O48S8
  • C72H104O48S88Na
  • API
  • 343306-79-6