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α-Cyclodextrin

Product Name
α-Cyclodextrin
CAS No.
10016-20-3
Chemical Name
α-Cyclodextrin
Synonyms
ALPHA-CYCLODEXTRIN;α-cyclodextrin;Alfadex;CYCLOHEXAAMYLOSE;Cyclohexapentylos;SCHARDINGER ALPHA-DEXTRIN;fadex;Cavamax? W6;Alfadex CRS;alpha-Dextrin
CBNumber
CB0163457
Molecular Formula
C36H60O30
Formula Weight
972.84
MOL File
10016-20-3.mol
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α-Cyclodextrin Property

Melting point:
>278 °C (dec.) (lit.)
Boiling point:
784.04°C (rough estimate)
alpha 
[α]D25 +146~+151° (c=1, H2O) (After Drying)
Density 
1.2580 (rough estimate)
refractive index 
1.7500 (estimate)
storage temp. 
2-8°C
solubility 
H2O: 50 mg/mL
form 
powder
pka
11.77±0.70(Predicted)
color 
White
PH
5.0-8.0 (1% in solution)
Odor
at 100.00?%. odorless
optical activity
[α]20/D +136±3°, c = 10% in H2O
Water Solubility 
Soluble in water at 1%(w/v)
Merck 
14,2718
BRN 
4227442
Stability:
Stable. Combustible. Incompatible with strong oxidizing agents.
InChIKey
HFHDHCJBZVLPGP-RWMJIURBSA-N
LogP
-7.77
CAS DataBase Reference
10016-20-3
NIST Chemistry Reference
«alpha»-Cyclodextrin(10016-20-3)
EPA Substance Registry System
.alpha.-Cyclodextrin (10016-20-3)
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Safety

Hazard Codes 
Xi
Risk Statements 
36-36/37/38
Safety Statements 
26-36
WGK Germany 
3
RTECS 
GU2292000
TSCA 
Yes
HS Code 
29400090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H319Causes serious eye irritation

Precautionary statements

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
PHR2560
Product name
Alpha Cyclodextrin
Packaging
1G
Price
$241
Updated
2024/03/01
Sigma-Aldrich
Product number
28705
Product name
α-Cyclodextrin
Purity
purum, ≥98.0% (HPLC)
Packaging
5g
Price
$28.8
Updated
2024/03/01
Sigma-Aldrich
Product number
1154558
Product name
Alpha Cyclodextrin
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
500mg
Price
$491
Updated
2024/03/01
TCI Chemical
Product number
C0776
Product name
Alpha Cyclodextrin
Purity
>98.0%(HPLC)
Packaging
10g
Price
$67
Updated
2024/03/01
TCI Chemical
Product number
C0776
Product name
Alpha Cyclodextrin
Purity
>98.0%(HPLC)
Packaging
25g
Price
$133
Updated
2024/03/01
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α-Cyclodextrin Chemical Properties,Usage,Production

Description

α-Cyclodextrine (α-CD) is a cyclic oligosaccharide derived from corn (Trade name: Mirafit fbcx, ArtJen Complexus, Windsor, Ontario, Canada). It has been shown to form a stable complex with dietary fat. This complex is resistant to normal lipolytic hydrolysis by lipases and thereby reduces the absorption and bioavailability of dietary fat[1].

Chemical Properties

White crystalline powder

Chemical Properties

Cyclodextrins occur as white, practically odorless, fine crystalline powders, having a slightly sweet taste. Some cyclodextrin derivatives occur as amorphous powders.

Uses

also available in pharma grade

Uses

A naturally occuring clathrate.

Uses

Useful for selective precipitation of enantiomeric, positional or structural isomersα-Cyclodextrin is used as a fiber ingredient, an odor or flavor masking agent. It is also useful for emulsification applications. It is also used as whipping fiber and emulsifying fiber. It finds application in medical, healthcare and food and beverage applications. It is also used to lower blood low-density lipoprotein cholesterol levels and lower blood triglyceride levels. It plays an essential role in fat free or fat containing dessert compositions and also employed for the reduction or the replacement of egg white in confectionary and bakery applications. Further, it acts as a supramolecular carrier, complexing agent and controlled drug release. In addition to this, it is used to increase the insulin and leptin sensitivity.

Production Methods

Cyclodextrins are manufactured by the enzymatic degradation of starch using specialized bacteria. For example, β-cyclodextrin is produced by the action of the enzyme cyclodextrin glucosyltransferase upon starch or a starch hydrolysate. An organic solvent is used to direct the reaction that produces β-cyclodextrin, and to prevent the growth of microorganisms during the enzymatic reaction. The insoluble complex of β-cyclodextrin and organic solvent is separated from the noncyclic starch, and the organic solvent is removed in vacuo so that less than 1 ppm of solvent remains in the β-cyclodextrin. The β-cyclodextrin is then carbon treated and crystallized from water, dried, and collected.

Definition

ChEBI: Alpha-cyclodextrin is a cycloamylose composed of six alpha-(1->4) linked D-glucopyranose units.

General Description

Hexagonal plates or blade-shaped needles.

Reactivity Profile

Cyclohexapentylose has hydrophobic cavities. Cyclohexapentylose forms inclusion compounds with organic substances, salts, and halogens in the solid state or in aqueous solutions. Cyclohexapentylose is incompatible with strong oxidizing agents.

Fire Hazard

Flash point data for Cyclohexapentylose are not available; however, Cyclohexapentylose is probably combustible.

Flammability and Explosibility

Non flammable

Pharmaceutical Applications

Cyclodextrins (α-Cyclodextrine) are ‘bucketlike’ or ‘conelike’ toroid molecules, with a rigid structure and a central cavity, the size of which varies according to the cyclodextrin type. The internal surface of the cavity is hydrophobic and the outside of the torus is hydrophilic; this is due to the arrangement of hydroxyl groups within the molecule. This arrangement permits the cyclodextrin to accommodate a guest molecule within the cavity, forming an inclusion complex.Cyclodextrins may be used to form inclusion complexes with a variety of drug molecules, resulting primarily in improvements to dissolution and bioavailability owing to enhanced solubility and improved chemical and physical stability.
Cyclodextrin inclusion complexes have also been used to mask the unpleasant taste of active materials and to convert a liquid substance into a solid material.
a-Cyclodextrin is used mainly in parenteral formulations. However, as it has the smallest cavity of the cyclodextrins it can form inclusion complexes with only relatively few, small-sized molecules. In contrast, g-cyclodextrin has the largest cavity and can be used to form inclusion complexes with large molecules; it has low toxicity and enhanced water solubility.
In parenteral formulations, cyclodextrins have been used to produce stable and soluble preparations of drugs that would otherwise have been formulated using a nonaqueous solvent.
In eye drop formulations, cyclodextrins form water-soluble complexes with lipophilic drugs such as corticosteroids. They have been shown to increase the water solubility of the drug; to enhance drug absorption into the eye; to improve aqueous stability; and to reduce local irritation.
Cyclodextrins have also been used in the formulation of solutions,suppositories, and cosmetics.

Biochem/physiol Actions

α-Cyclodextrin is found to form a firm complex with dietary fats. This way it decreases the bioavailability and absorption of fats. It is known to regulate triglyceride and leptin levels in serum. In rat models, α-Cyclodextrin is shown to induce insulin sensitivity and fecal fat excretion. Thus, α-cyclodextrin is considered to be effective for treating obesity and metabolic syndromes.

Safety

Cyclodextrins are starch derivatives and are mainly used in oral and parenteral pharmaceutical formulations. They are also used in topical and ophthalmic formulations.
Cyclodextrins are also used in cosmetics and food products, and are generally regarded as essentially nontoxic and nonirritant materials. However, when administered parenterally, β-cyclodextrin is not metabolized but accumulates in the kidneys as insoluble cholesterol complexes, resulting in severe nephrotoxicity.
Cyclodextrin administered orally is metabolized by microflora in the colon, forming the metabolites maltodextrin, maltose, and glucose; these are themselves further metabolized before being finally excreted as carbon dioxide and water. Although a study published in 1957 suggested that orally administered cyclodextrins were highly toxic, more recent animal toxicity studies in rats and dogs have shown this not to be the case, and cyclodextrins are now approved for use in food products and orally administered pharmaceuticals in a number of countries.
Cyclodextrins are not irritant to the skin and eyes, or upon inhalation. There is also no evidence to suggest that cyclodextrins are mutagenic or teratogenic.
α-Cyclodextrin
LD50 (rat, IP): 1.0 g/kg(15)
LD50 (rat, IV): 0.79 g/kg

storage

Cyclodextrins should be stored in a tightly sealed container, in a cool, dry place.Cyclodextrins are stable in the solid state if protected from high humidity.

Purification Methods

Recrystallise α-cyclodextrin from 60% aqueous EtOH, then twice from water, and dry it for 12hours in a vacuum at 80o. It is also purified by precipitation from water with 1,1,2-trichloroethylene. The precipitate is collected, washed and resuspended in water. This is boiled to steam distil the trichloroethylene. The solution is then freeze-dried to recover the cyclodextrin. [Armstrong et al. J Am Chem Soc 108 1418 1986]. [Beilstein 19/12 V 789.]

Regulatory Status

Included in the FDA Inactive Ingredients Database: α-cyclodextrin (injection preparations); β-cyclodextrin (oral tablets, topical gels); γ-cyclodextrin (IV injections).
Included in the Canadian List of Acceptable Non-medicinal Ingredients (stabilizing agent; solubilizing agent ); and in oral and rectal pharmaceutical formulations licensed in Europe, Japan, and the USA.

References

[1] Kevin B. Comerford. “The Beneficial Effects α-Cyclodextrin on Blood Lipids and Weight Loss in Healthy Humans.” Obesity 19 6 (2012): 1200–1204.

α-Cyclodextrin Preparation Products And Raw materials

Raw materials

Preparation Products

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α-Cyclodextrin Suppliers

Tocopharm Co., Ltd.
Tel
+86-021-69895597 13776836200 +86-13776836200
Fax
021-61292409
Email
tocopharm@gmail.com
Country
China
ProdList
188
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55
Shandong Zhiyuan Biotechnology Co., Ltd.
Tel
0543-8128041 13562317646
Fax
0543-2605568
Email
2370211093@qq.com
Country
China
ProdList
48
Advantage
58
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
021-61259108 18621169109
Fax
86-21-61259102
Email
market03@meryer.com
Country
China
ProdList
40240
Advantage
62
3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Fax
86-21-50328109
Email
3bsc@sina.com
Country
China
ProdList
15848
Advantage
69
Alfa Aesar
Tel
400-6106006
Fax
021-67582001/03/05
Email
saleschina@alfa-asia.com
Country
China
ProdList
30132
Advantage
84
TCI (Shanghai) Development Co., Ltd.
Tel
021-67121386
Fax
021-67121385
Email
Sales-CN@TCIchemicals.com
Country
China
ProdList
24539
Advantage
81
Beijing HwrkChemical Technology Co., Ltd
Tel
010-89508211 18501085097
Fax
010-89508210
Email
sales.bj@hwrkchemical.com
Country
China
ProdList
8415
Advantage
55
Energy Chemical
Tel
021-021-58432009 400-005-6266
Fax
021-58436166
Email
sales8178@energy-chemical.com
Country
China
ProdList
44700
Advantage
61
JinYan Chemicals(ShangHai) Co.,Ltd.
Tel
13817811078
Fax
86-021-50426522,50426273
Email
sales@jingyan-chemical.com
Country
China
ProdList
9984
Advantage
60
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View Lastest Price from α-Cyclodextrin manufacturers

Hebei Zhuanglai Chemical Trading Co.,Ltd
Product
Cyclohexapentylose 10016-20-3
Price
US $85.00-35.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
20ton
Release date
2024-05-24
WUHAN FORTUNA CHEMICAL CO., LTD
Product
Cyclohexapentylose 10016-20-3
Price
US $1.00/KG
Min. Order
1KG
Purity
≥99.00%
Supply Ability
10ton/month
Release date
2024-02-28
Hebei Chuanghai Biotechnology Co,.LTD
Product
Cyclohexapentylose 10016-20-3
Price
US $15.60/KG
Min. Order
1KG
Purity
99%
Supply Ability
5000kg
Release date
2024-08-09

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