ChemicalBook > CAS DataBase List > Cyclohexapentylose

Cyclohexapentylose

Product Name
Cyclohexapentylose
CAS No.
10016-20-3
Chemical Name
Cyclohexapentylose
Synonyms
fadex;Alfadex;Cavamax? W6;Alfadex CRS;alpha-Dextrin;α-Cydodextrin;Ncgc00090767-01;a-Cyclodextrin.;CYCLOHEXAAMYLOSE;CYCLOMALTOHEXOSE
CBNumber
CB0163457
Molecular Formula
C36H60O30
Formula Weight
972.84
MOL File
10016-20-3.mol
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Cyclohexapentylose Property

Melting point:
>278 °C (dec.)(lit.)
alpha 
[α]D25 +146~+151° (c=1, H2O) (After Drying)
Boiling point:
784.04°C (rough estimate)
Density 
1.2580 (rough estimate)
refractive index 
1.7500 (estimate)
storage temp. 
Store at RT.
solubility 
H2O: 50 mg/mL
pka
11.77±0.70(Predicted)
form 
powder
color 
White
PH
5.0-8.0 (1% in solution)
optical activity
[α]20/D +136±3°, c = 10% in H2O
Water Solubility 
Soluble in water at 1%(w/v)
Merck 
14,2718
BRN 
4227442
Stability:
Stable. Combustible. Incompatible with strong oxidizing agents.
InChIKey
HFHDHCJBZVLPGP-RWMJIURBSA-N
CAS DataBase Reference
10016-20-3
NIST Chemistry Reference
«alpha»-Cyclodextrin(10016-20-3)
EPA Substance Registry System
.alpha.-Cyclodextrin (10016-20-3)
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Safety

Hazard Codes 
Xi
Risk Statements 
36-36/37/38
Safety Statements 
26-36
WGK Germany 
3
RTECS 
GU2292000
TSCA 
Yes
HS Code 
29400090
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
28705
Product name
α-Cyclodextrin
Purity
purum, ≥98.0% (HPLC)
Packaging
5g
Price
$145
Updated
2020/08/18
Sigma-Aldrich
Product number
1154558
Product name
Alpha Cyclodextrin
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
500mg
Price
$414
Updated
2020/08/18
TCI Chemical
Product number
C0776
Product name
alpha-Cyclodextrin
Purity
>98.0%(HPLC)
Packaging
10g
Price
$54
Updated
2020/06/24
TCI Chemical
Product number
C0776
Product name
alpha-Cyclodextrin
Purity
>98.0%(HPLC)
Packaging
25g
Price
$110
Updated
2020/06/24
Alfa Aesar
Product number
J60687
Product name
alpha-Cyclodextrin, 97+%
Packaging
25g
Price
$129
Updated
2020/06/24
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Cyclohexapentylose Chemical Properties,Usage,Production

Chemical Properties

White crystalline powder

Chemical Properties

Cyclodextrins occur as white, practically odorless, fine crystalline powders, having a slightly sweet taste. Some cyclodextrin derivatives occur as amorphous powders.

Uses

also available in pharma grade

Uses

A naturally occuring clathrate.

Production Methods

Cyclodextrins are manufactured by the enzymatic degradation of starch using specialized bacteria. For example, β-cyclodextrin is produced by the action of the enzyme cyclodextrin glucosyltransferase upon starch or a starch hydrolysate. An organic solvent is used to direct the reaction that produces β-cyclodextrin, and to prevent the growth of microorganisms during the enzymatic reaction. The insoluble complex of β-cyclodextrin and organic solvent is separated from the noncyclic starch, and the organic solvent is removed in vacuo so that less than 1 ppm of solvent remains in the β-cyclodextrin. The β-cyclodextrin is then carbon treated and crystallized from water, dried, and collected.

General Description

Hexagonal plates or blade-shaped needles.

Reactivity Profile

Cyclohexapentylose has hydrophobic cavities. Cyclohexapentylose forms inclusion compounds with organic substances, salts, and halogens in the solid state or in aqueous solutions. Cyclohexapentylose is incompatible with strong oxidizing agents.

Fire Hazard

Flash point data for Cyclohexapentylose are not available; however, Cyclohexapentylose is probably combustible.

Pharmaceutical Applications

Cyclodextrins are ‘bucketlike’ or ‘conelike’ toroid molecules, with a rigid structure and a central cavity, the size of which varies according to the cyclodextrin type. The internal surface of the cavity is hydrophobic and the outside of the torus is hydrophilic; this is due to the arrangement of hydroxyl groups within the molecule. This arrangement permits the cyclodextrin to accommodate a guest molecule within the cavity, forming an inclusion complex.
Cyclodextrins may be used to form inclusion complexes with a variety of drug molecules, resulting primarily in improvements to dissolution and bioavailability owing to enhanced solubility and improved chemical and physical stability.
Cyclodextrin inclusion complexes have also been used to mask the unpleasant taste of active materials and to convert a liquid substance into a solid material.
a-Cyclodextrin is used mainly in parenteral formulations. However, as it has the smallest cavity of the cyclodextrins it can form inclusion complexes with only relatively few, small-sized molecules. In contrast, g-cyclodextrin has the largest cavity and can be used to form inclusion complexes with large molecules; it has low toxicity and enhanced water solubility.
In parenteral formulations, cyclodextrins have been used to produce stable and soluble preparations of drugs that would otherwise have been formulated using a nonaqueous solvent.
In eye drop formulations, cyclodextrins form water-soluble complexes with lipophilic drugs such as corticosteroids. They have been shown to increase the water solubility of the drug; to enhance drug absorption into the eye; to improve aqueous stability; and to reduce local irritation.
Cyclodextrins have also been used in the formulation of solutions,suppositories, and cosmetics.

Safety

Cyclodextrins are starch derivatives and are mainly used in oral and parenteral pharmaceutical formulations. They are also used in topical and ophthalmic formulations.
Cyclodextrins are also used in cosmetics and food products, and are generally regarded as essentially nontoxic and nonirritant materials. However, when administered parenterally, β-cyclodextrin is not metabolized but accumulates in the kidneys as insoluble cholesterol complexes, resulting in severe nephrotoxicity.
Cyclodextrin administered orally is metabolized by microflora in the colon, forming the metabolites maltodextrin, maltose, and glucose; these are themselves further metabolized before being finally excreted as carbon dioxide and water. Although a study published in 1957 suggested that orally administered cyclodextrins were highly toxic, more recent animal toxicity studies in rats and dogs have shown this not to be the case, and cyclodextrins are now approved for use in food products and orally administered pharmaceuticals in a number of countries.
Cyclodextrins are not irritant to the skin and eyes, or upon inhalation. There is also no evidence to suggest that cyclodextrins are mutagenic or teratogenic.
α-Cyclodextrin
LD50 (rat, IP): 1.0 g/kg(15)
LD50 (rat, IV): 0.79 g/kg

storage

Cyclodextrins should be stored in a tightly sealed container, in a cool, dry place.Cyclodextrins are stable in the solid state if protected from high humidity.

Purification Methods

Recrystallise α-cyclodextrin from 60% aqueous EtOH, then twice from water, and dry it for 12hours in a vacuum at 80o. It is also purified by precipitation from water with 1,1,2-trichloroethylene. The precipitate is collected, washed and resuspended in water. This is boiled to steam distil the trichloroethylene. The solution is then freeze-dried to recover the cyclodextrin. [Armstrong et al. J Am Chem Soc 108 1418 1986]. [Beilstein 19/12 V 789.]

Regulatory Status

Included in the FDA Inactive Ingredients Database: α-cyclodextrin (injection preparations); β-cyclodextrin (oral tablets, topical gels); γ-cyclodextrin (IV injections).
Included in the Canadian List of Acceptable Non-medicinal Ingredients (stabilizing agent; solubilizing agent ); and in oral and rectal pharmaceutical formulations licensed in Europe, Japan, and the USA.

Cyclohexapentylose Preparation Products And Raw materials

Raw materials

Preparation Products

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Cyclohexapentylose Suppliers

Tocopharm Co., Ltd.
Tel
021-69895597- ;021-69895597- ;021-69895597-
Fax
021-61292409
Email
info@tocopharm.com;sales@tocopharm.com;739486509@qq.com
Country
China
ProdList
189
Advantage
55
Shandong Zhiyuan Biotechnology Co., Ltd.
Tel
0543-8128041-
Fax
0543-2605568
Email
2370211093@qq.com;
Country
China
ProdList
42
Advantage
58
J & K SCIENTIFIC LTD.
Tel
010-82848833- ;010-82848833-
Fax
86-10-82849933
Email
jkinfo@jkchemical.com;market6@jkchemical.com
Country
China
ProdList
96504
Advantage
76
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
21-61259100-
Fax
86-21-61259102
Email
sh@meryer.com
Country
China
ProdList
40268
Advantage
62
3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801
Fax
86-21-50328109
Email
3bsc@sina.com
Country
China
ProdList
15880
Advantage
69
Alfa Aesar
Tel
400-610-6006; 021-67582000
Fax
021-67582001/03/05
Email
saleschina@alfa-asia.com
Country
China
ProdList
30163
Advantage
84
TCI (Shanghai) Development Co., Ltd.
Tel
021-67121386 / 800-988-0390
Fax
021-67121385
Email
Sales-CN@TCIchemicals.com
Country
China
ProdList
24555
Advantage
81
BeiJing Hwrk Chemicals Limted
Tel
010-57411839-
Fax
021-55236763
Email
bjsales@hwrkchemical.com
Country
China
ProdList
18708
Advantage
55
Energy Chemical
Tel
021-58432009
Fax
021-58436166-800
Email
sales8178@energy-chemical.com
Country
China
ProdList
44026
Advantage
61
JinYan Chemicals(ShangHai) Co.,Ltd.
Tel
13817811078,021-50426030
Fax
86-021-50426522,50426273
Email
sales@jingyan-chemical.com
Country
China
ProdList
10009
Advantage
60
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View Lastest Price from Cyclohexapentylose manufacturers

Zhuozhou Wenxi import and Export Co., Ltd
Product
Alpha-Cyclodextrin 10016-20-3
Price
US $32.00/KG
Min. Order
1KG
Purity
99%,HPLC
Supply Ability
100kg
Release date
2020-09-10
Shandong Binzhou Zhiyuan Biotechnology Co., Ltd.
Product
α-cyclodextrin 10016-20-3
Price
US $40.00-0.00/Kg/Bag
Min. Order
1Kg/Bag
Purity
99.5%
Supply Ability
5MT
Release date
2020-01-17
Shandong Binzhou Zhiyuan Biotechnology Co., Ltd.
Product
alpha-cyclodextrin 10016-20-3
Price
US $40.00-0.00/Kg/Bag
Min. Order
1Kg/Bag
Purity
99.5%
Supply Ability
5MT
Release date
2020-01-17

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