ChemicalBook > CAS DataBase List > Amifostine Thiol Dihydrochloride

Amifostine Thiol Dihydrochloride

Product Name: Amifostine Thiol Dihydrochloride
CAS No.: 14653-77-1
Chemical Name: Amifostine Thiol Dihydrochloride
Synonyms: SKL052;WR-1065 2HCl;AMifostine Thiol;WR-1065 dihydrochloride;Amifostine Impurity 1 DiHCl;Amifostine Impurity 10 DiHCl;Amifostine Thiol Dihydrochloride;Amifostine thiol (hydrochloride);Amifostine Thiol Dihydrochloride (90%);Amifostine Impurity 2（Amifostine Thiol）
CBNumber: CB32502994
Molecular Formula: C5H14N2S
Formula Weight: 134.24306
MOL File: 14653-77-1.mol

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Amifostine Thiol Dihydrochloride Property

Melting point:: 184-186°C
storage temp.: -20°C
solubility: H2O: ≥20mg/mL
form: powder
color: white to off-white
Water Solubility: H2O: ≥20mg/mL
Stability:: Hygroscopic
InChI: InChI=1S/C5H14N2S/c6-2-1-3-7-4-5-8/h7-8H,1-6H2
InChIKey: YHPLKWQJMAYFCN-UHFFFAOYSA-N
SMILES: NCCCNCCS

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Safety

Hazard Codes: Xn
Risk Statements: 22-41
Safety Statements: 26-39-41
WGK Germany: 3
HS Code: 2930909165
Toxicity: mouse,LD50,intraperitoneal,400mg/kg (400mg/kg),European Journal of Medicinal Chemistry--Chimie Therapeutique. Vol. 24, Pg. 48, 1989.

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H302Harmful if swallowed

H318Causes serious eye damage

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: W2020
Product name: WR-1065
Purity: ≥98% (HPLC)
Packaging: 10mg
Price: $97.85
Updated: 2025/07/31

Sigma-Aldrich

Product number: PHR2992
Product name: Amifostine Thiol
Purity: pharmaceutical secondary standard, certified reference material
Packaging: 100MG
Price: $538
Updated: 2025/07/31

Sigma-Aldrich

Product number: 1019428
Product name: Amifostine thiol
Purity: United States Pharmacopeia (USP) Reference Standard
Packaging: 50mg
Price: $1200
Updated: 2025/07/31

Cayman Chemical

Product number: 18612
Product name: Amifostine thiol (hydrochloride)
Packaging: 5mg
Price: $45
Updated: 2024/03/01

Cayman Chemical

Product number: 18612
Product name: Amifostine thiol (hydrochloride)
Packaging: 10mg
Price: $81
Updated: 2024/03/01

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Amifostine Thiol Dihydrochloride Chemical Properties,Usage,Production

Chemical Properties

White Solid

Uses

A metabolite of Amifostine.

Biochem/physiol Actions

WR-1065 is cytoprotective cell-permeable reactive oxygen species scavenger and p53 activator and re-activator. Recently shown to have antiretroviral activity and an active metabolite of Amifostine which selectively protects normal tissues from the damaging effects of anti-neoplastic radiation therapy.

in vivo

The results show that Amifostine thiol dihydrochloride (Amifostine thiol) attenuates the severity of 6-OHDA-induced catalepsy (P<0.001) when compare with 6-OHDA-lesioned rats. Also it has been observed that Amifostine thiol dihydrochloride improves catalepsy in dose dependent manner (P<0.001). Pretreatment with three different doses of Amifostine thiol dihydrochloride (20, 40 and 80 μg/2 μL/rat) for 3 days before 6-OHDA administration, significantly (P<0.001) elevates SOD activity and restores it to normal range compare with 6-OHDA lesioned rats^[3].

storage

Desiccate at -20°C

Amifostine Thiol Dihydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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14653-77-1, Amifostine Thiol DihydrochlorideRelated Search:

4-ETHYLCATECHOL Octyl 4-methoxycinnamate Thioacetamide Potassium phthalimide Phenyl chlorothionocarbonate PHOSPHOENOLPYRUVIC ACID MONOPOTASSIUM SALT Potassium di-tert-butyl phosphate WRW4 BRL 6231 WRG-28 N,N-Diisopropylethylamine

Amifostine Thiol Dihydrochloride

2-[(3-Aminopropyl)amino]ethanethioldihydrochloride

Amifostine Thiol (50 mg) (2-[(3-aminopropyl)amino]ethanethiol, dihydrochloride)

AMifostine Thiol

2-[(3-AMinopropyl)aMino]ethanethiol Hydrochloride

WR-1065 dihydrochloride

WR-1065 2HCl

Amifostine Thiol Dihydrochloride (90%)

2-[(3-aminopropyl)amino]ethane-1-thiol dihydrochloride

Amifostine Impurity 2（Amifostine Thiol）

SKL052

Ethanethiol, 2-[(3-aminopropyl)amino]-, hydrochloride (1:2)

Amifostine Thiol Dihydrochloride-d4Q: What is Amifostine Thiol Dihydrochloride-d4 Q: What is the CAS Number of Amifostine Thiol Dihydrochloride-d4

Amifostine Thiol-13C3 DihydrochlorideQ: What is Amifostine Thiol-13C3 Dihydrochloride Q: What is the CAS Number of Amifostine Thiol-13C3 Dihydrochloride

Amifostine Thiol (2-[(3-aminopropyl)amino]ethanethiol, dihydrochloride) (1019428)

WR1065,Amifostine thiol dihydrochloride,Inhibitor,MDM-2/p53,WR-1065,Amifostine thiol,inhibit

Amifostine thiol (hydrochloride)

Amifostine Thiol (50 mg) (Ethanethiol, 2-[(3-aminopropyl)amino]-, dihydrochloride)

Amifostine Impurity 1 DiHCl

Amifostine Impurity 10 DiHCl

Amifostine thiol dihydrochloride, 10 mM in DMSO

14653-77-1

C5H16Cl2N2S

C5H14N2S2HCl

Intermediates & Fine Chemicals

Metabolites & Impurities

Pharmaceuticals

Sulfur & Selenium Compounds