BRL 6231

Product Name: BRL 6231
CAS No.: 47326-86-3
Chemical Name: BRL 6231
Synonyms: BRL 6231;WR-99210;Antifolate,Inhibitor,Bacterial,WR 99210,inhibit,WR99210,WR-99210;6,6-dimethyl-1-(3-(2,4,5-trichlorophenoxy)propoxy)-1,6-dihydro-1,3,5-triazine-2,4-diamine;1,6-Dihydro-6,6-dimethyl-1-[3-(2,4,5-trichlorophenoxy)propoxy]-1,3,5-triazine-2,4-diamine;5-[3-(2,4,5-Trichlorophenoxy)propoxy]-6,6-dimethyl-5,6-dihydro-1,3,5-triazine-2,4-diamine;1,3,5-Triazine-2,4-diamine, 1,6-dihydro-6,6-dimethyl-1-[3-(2,4,5-trichlorophenoxy)propoxy]-;1-[3-[(2,4,5-Trichlorophenyl)oxy]propoxy]-1,6-dihydro-6,6-dimethyl-1,3,5-triazine-2,4-diamine
CBNumber: CB81359536
Molecular Formula: C14H18Cl3N5O2
Formula Weight: 394.68
MOL File: 47326-86-3.mol

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BRL 6231 Property

Boiling point:: 519.7±60.0 °C(Predicted)
Density: 1.52±0.1 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: DMSO: soluble0.2mg/mL, clear (warmed)
pka: 8.48±0.40(Predicted)
form: powder
color: white to off-white

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Safety

WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0065315
Product name: WR99210
Purity: 99.57%
Packaging: 10mg
Price: $270
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: INB0000976
Product name: WR99210
Purity: 95.00%
Packaging: 5MG
Price: $697.51
Updated: 2021/12/16

ChemScene

Product number: CS-0065315
Product name: WR99210
Purity: 99.57%
Packaging: 50mg
Price: $895
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: INB0000976
Product name: WR99210
Purity: 95.00%
Packaging: 25MG
Price: $1029.63
Updated: 2021/12/16

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BRL 6231 Chemical Properties,Usage,Production

Uses

WR99210 is an orally active and low-toxicity dihydrofolate reductase (DHFR) inhibitor (IC50<0.075 nM). WR99210 shows good antiparasitic activity and is effective against P. falciparum and P. falciparum strains (including Pyrimethamine.html" class="link-product" target="_blank">Pyrimethamine (HY-18062)-resistant P. falciparum strains) as well as T. gondii[1][2][3].

Biochem/physiol Actions

WR99210 is a potent inhibitor of Plasmodium falciparum dihydrofolate reductase (DHFR), which is a major malarial drug target. It has subnanomolar potency for the wild type, double mutant and quadruple mutant dihydrofolate reductases.

in vivo

WR99210 (1.25 mg/kg; i.p.; single daily for 5 days) is highly effective against T. gondii tachyzoites in a mouse model^[1].

Animal Model:	Male mice (T. gondii-infected)^[1].
Dosage:	1.25 mg/kg
Administration:	Intraperitoneal injection; single daily for 5 days.
Result:	Exhibited intraperitoneal parasite numbers were 2 logs less in mice on the day 5.

References

[1] Mui EJ, et al. Triazine Inhibits Toxoplasma gondii tachyzoites in vitro and in vivo. Antimicrob Agents Chemother. 2005 Aug;49(8):3463-7. DOI:10.1128/AAC.49.8.3463-3467.2005
[2] Hastings MD, et al. Pyrimethamine and WR99210 exert opposing selection on dihydrofolatereductase from Plasmodium vivax. Proc Natl Acad Sci U S A. 2002 Oct 1;99(20):13137-41. DOI:10.1073/pnas.182295999
[3] Kiara SM, et al. In vitro activity of antifolate and polymorphism in dihydrofolate reductase of Plasmodium falciparum isolates from the Kenyan coast: emergence of parasites with Ile-164-Leu mutation. Antimicrob Agents Chemother. 2009 Sep;53(9):3793-8. DOI:10.1128/AAC.00308-09

BRL 6231 Preparation Products And Raw materials

Raw materials

Preparation Products

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BRL 6231 Suppliers

China 22 United States 3 Global 25

Sigma-Aldrich

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Shanghai EFE Biological Technology Co., Ltd.

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Shanghai Chaolan Chemical Technology Center

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Beijing Jin Ming Biotechnology Co., Ltd.

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Fan De(Beijing) Biotechnology Co., Ltd.

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TargetMol Chemicals Inc.

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Career Henan Chemica Co

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ChemeGen(Shanghai) Biotechnology Co.,Ltd.

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Huansheng Meisen Pharmaceutical Technology (Shandong) Co., Ltd

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Email: sales@acespharma.com
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Energy Chemical

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47326-86-3, BRL 6231Related Search:

WRW4 WRG-28 Amifostine Thiol Dihydrochloride

BRL 6231

1-[3-[(2,4,5-Trichlorophenyl)oxy]propoxy]-1,6-dihydro-6,6-dimethyl-1,3,5-triazine-2,4-diamine

5-[3-(2,4,5-Trichlorophenoxy)propoxy]-6,6-dimethyl-5,6-dihydro-1,3,5-triazine-2,4-diamine

WR-99210

1,6-Dihydro-6,6-dimethyl-1-[3-(2,4,5-trichlorophenoxy)propoxy]-1,3,5-triazine-2,4-diamine

6,6-dimethyl-1-(3-(2,4,5-trichlorophenoxy)propoxy)-1,6-dihydro-1,3,5-triazine-2,4-diamine

Antifolate,Inhibitor,Bacterial,WR 99210,inhibit,WR99210,WR-99210

1,3,5-Triazine-2,4-diamine, 1,6-dihydro-6,6-dimethyl-1-[3-(2,4,5-trichlorophenoxy)propoxy]-

47326-86-3