5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)benzo[d]oxazole

Product Name: 5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)benzo[d]oxazole
CAS No.: 936902-12-4
Chemical Name: 5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)benzo[d]oxazole
Synonyms: Benzoxazole-5-boronic Acid Pinacol Ester;Benzooxazole-5-boronic acid pinacol ester;Benzo[d]oxazole-5-boronic acid pinacol ester;benzo[d]oxazol-5-ylboronic acid pinacol ester;Benzooxazole-5-boronic acid pinacol ester 97%;1,3-Benzoxazole-5-boronic acid, pinacol ester;Benzoxazole, 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-;5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)benzo[d]oxazole;5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzo[d]oxazo...;5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1,3-benzoxazole
CBNumber: CB32513545
Molecular Formula: C13H16BNO3
Formula Weight: 245.08
MOL File: 936902-12-4.mol

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5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)benzo[d]oxazole Property

Melting point:: 88-93°C
Boiling point:: 350.1±15.0 °C(Predicted)
Density: 1.14±0.1 g/cm3(Predicted)
storage temp.: 2-8°C
pka: 0.17±0.10(Predicted)
form: solid
Appearance: White to yellow Solid

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Safety

Hazard Codes: Xn
Risk Statements: 20/21/22
WGK Germany: 3
HS Code: 2934999090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 741450
Product name: Benzooxazole-5-boronic acid pinacol ester
Purity: 97%
Packaging: 250mg
Price: $76.4
Updated: 2023/06/20

Sigma-Aldrich

Product number: 741450
Product name: Benzooxazole-5-boronic acid pinacol ester
Purity: 97%
Packaging: 1g
Price: $234
Updated: 2023/06/20

TRC

Product number: B694118
Product name: Benzooxazole-5-boronic acid pinacol ester
Packaging: 50mg
Price: $55
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB161239
Product name: Benzooxazole-5-boronic acid pinacol ester
Packaging: 50mg
Price: $55
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB161239
Product name: Benzooxazole-5-boronic acid pinacol ester
Packaging: 100mg
Price: $88
Updated: 2021/12/16

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5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)benzo[d]oxazole Chemical Properties,Usage,Production

Synthesis

132244-31-6

73183-34-3

936902-12-4

5-Bromobenzoxazole (1 g, 5.05 mmol), pinacol ester of bisboronic acid (1.54 g, 6.06 mmol), potassium acetate (1.49 g, 15.15 mmol) and Pd(dppf)Cl2 (184.76 mg, 0.25 mmol) were used as raw materials, and the above reagents were added to a reaction flask under nitrogen protection, using 1,4-dioxane as solvent. The reaction mixture was stirred at 100 °C for 8 hours. After completion of the reaction, it was cooled to room temperature and the solvent was removed by distillation under reduced pressure. The crude product was purified by column chromatography to afford 1.03 g of the target product benzoxazole-5-boronic acid pinacol ester in white powder form in 83.4% yield.

References

[1] Journal of Medicinal Chemistry, 2017, vol. 60, # 14, p. 6337 - 6352
[2] Patent: CN108503634, 2018, A. Location in patent: Paragraph 0316; 0317; 0320; 0321
[3] Patent: US2016/318895, 2016, A1. Location in patent: Paragraph 0300
[4] Journal of Medicinal Chemistry, 2018, vol. 61, # 23, p. 10724 - 10738
[5] Patent: WO2011/14795, 2011, A2. Location in patent: Page/Page column 94

5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)benzo[d]oxazole Preparation Products And Raw materials

Raw materials

Preparation Products

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5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)benzo[d]oxazole Suppliers

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936902-12-4, 5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)benzo[d]oxazoleRelated Search:

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5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)benzo[d]oxazole

Benzooxazole-5-boronic acid pinacol ester

1,3-Benzoxazole-5-boronic acid, pinacol ester

5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1,3-benzoxazole

benzo[d]oxazol-5-ylboronic acid pinacol ester

Benzo[d]oxazole-5-boronic acid pinacol ester

Benzooxazole-5-boronic acid pinacol ester 97%

Benzoxazole-5-boronic Acid Pinacol Ester

Benzoxazole, 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-

5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzo[d]oxazo...

936902-12-4