STAT5 Inhibitor

ChemicalBook > CAS DataBase List > STAT5 Inhibitor

Product Name: STAT5 Inhibitor
CAS No.: 285986-31-4
Chemical Name: STAT5 Inhibitor
Synonyms: MDK6314;CS-2509;STAT5-IN-1;STAT5 Inhibitor;STAT5 Inhibitor 1;Stat5 Inhibitor(STAT5-IN-1);N'-[(4-oxo-4H-chromen-3-yl)methylene]nicotinohydrazide;STAT-5-IN-1,STAT5IN1,inhibit,STAT5 IN 1,Inhibitor,STAT;N'-((4-Oxo-4H-chromen-3-yl)methylene)nicotinohydrazide;(E)-N'-((4-oxo-4H-chromen-3-yl)methylene)nicotinohydrazide
CBNumber: CB32515923
Molecular Formula: C16H11N3O3
Formula Weight: 293.28
MOL File: 285986-31-4.mol

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STAT5 Inhibitor Property

Melting point:: 214-216 °C
Density: 1.33±0.1 g/cm3(Predicted)
storage temp.: 2-8°C(protect from light)
solubility: ≥9.58 mg/mL in DMSO; insoluble in EtOH; insoluble in H2O
form: crystalline solid
pka: 10.44±0.46(Predicted)
color: White to light yellow

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 573108-M
Product name: STAT5 Inhibitor - CAS 285986-31-4 - Calbiochem
Purity: The STAT5 Inhibitor, also referenced under CAS 285986-31-4, controls the biological activity of STAT5.
Packaging: 10MG
Price: $148
Updated: 2024/03/01

Cayman Chemical

Product number: 15784
Product name: STAT5 Inhibitor
Purity: ≥95%
Packaging: 5mg
Price: $68
Updated: 2024/03/01

Cayman Chemical

Product number: 15784
Product name: STAT5 Inhibitor
Purity: ≥95%
Packaging: 10mg
Price: $130
Updated: 2024/03/01

Cayman Chemical

Product number: 15784
Product name: STAT5 Inhibitor
Purity: ≥95%
Packaging: 25mg
Price: $286
Updated: 2024/03/01

ApexBio Technology

Product number: C4105
Product name: STAT5Inhibitor
Packaging: 25mg
Price: $324
Updated: 2021/12/16

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STAT5 Inhibitor Chemical Properties,Usage,Production

Description

Signal Transducers and Activators of Transcriptions (STATs) are a family of cytoplasmic latent transcription factors that are activated to regulate gene expression in response to a large number of extracellular signaling polypeptides including cytokines, interferons, and growth factors. STAT5, which consists of two isoforms STAT5α and STAT5β, is known to be overactive in several kinds of leukemias and various solid tumors. STAT5 Inhibitor is a cell-permeable, nonpetidic nicotinoyl hydrazone that suppresses STAT5 by targeting its SH2 domain (IC₅₀ = 47 μM against STAT5β SH2 domain EPO peptide binding activity). Comparatively, this compound exhibits reduced potency towards inhibiting the SH2 domain of STAT1, STAT3, or Lck (IC₅₀ > 500 μM). STAT5 Inhibitor has been shown to block STAT5/STAT5 DNA binding in K562 nuclear extracts.

Uses

2-?[(4-?Oxo-?4H-?1-?benzopyran-?3-?yl)?methylene]?hydrazide-3-?pyridinecarboxylic Acid is a selective inhibitor of STAT5.

Definition

ChEBI: A carbohydrazide that is nicotinohydrazide in which the terminal nitrogen has undergone formal condensation with the aldehyde group of 4-oxo-4H-chromene-3-carbaldehyde. It is an inhibitor of STAT5 (Signal Transducer and Activator of Tran cription 5) protein.

References

[1]. müller j, sperl b, reindl w, et al. discovery of chromone-based inhibitors of the transcription factor stat5. chembiochem. 2008 mar 25;9(5):723-7.
[2]. leonard wj, o'shea jj. jaks and stats: biological implications. annu rev immunol. 1998;16:293-322.
[3]. schindler c, darnell je jr. transcriptional responses to polypeptide ligands: the jak-stat pathway. annu rev biochem. 1995;64:621-51.

STAT5 Inhibitor Preparation Products And Raw materials

Raw materials

Preparation Products

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285986-31-4, STAT5 InhibitorRelated Search:

STAT5 Inhibitor

CS-2509

STAT5-IN-1

N'-[(4-oxo-4H-chromen-3-yl)methylene]nicotinohydrazide

STAT5 Inhibitor 1

(E)-N'-((4-oxo-4H-chromen-3-yl)methylene)nicotinohydrazide

MDK6314

3-Pyridinecarboxylic acid, 2-[(4-oxo-4H-1-benzopyran-3-yl)methylene]hydrazide

STAT-5-IN-1,STAT5IN1,inhibit,STAT5 IN 1,Inhibitor,STAT

Stat5 Inhibitor(STAT5-IN-1)

N'3-[(4-oxo-4H-chromen-3-yl)methylidene]pyridine-3-carbohydrazide

N'-((4-Oxo-4H-chromen-3-yl)methylene)nicotinohydrazide

3-{[(1E)-2-(pyridin-3-ylcarbonyl)diazanylidene]methyl}-4H-chromen-4-one

285986-31-4