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STAT5 Inhibitor

Product Name
STAT5 Inhibitor
CAS No.
285986-31-4
Chemical Name
STAT5 Inhibitor
Synonyms
MDK6314;CS-2509;STAT5-IN-1;STAT5 Inhibitor;STAT5 Inhibitor 1;Stat5 Inhibitor(STAT5-IN-1);N'-[(4-oxo-4H-chromen-3-yl)methylene]nicotinohydrazide;STAT-5-IN-1,STAT5IN1,inhibit,STAT5 IN 1,Inhibitor,STAT;N'-((4-Oxo-4H-chromen-3-yl)methylene)nicotinohydrazide;(E)-N'-((4-oxo-4H-chromen-3-yl)methylene)nicotinohydrazide
CBNumber
CB32515923
Molecular Formula
C16H11N3O3
Formula Weight
293.28
MOL File
285986-31-4.mol
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STAT5 Inhibitor Property

Melting point:
214-216 °C
Density 
1.33±0.1 g/cm3(Predicted)
storage temp. 
2-8°C(protect from light)
solubility 
≥9.58 mg/mL in DMSO; insoluble in EtOH; insoluble in H2O
form 
crystalline solid
pka
10.44±0.46(Predicted)
color 
White to light yellow
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
573108-M
Product name
STAT5 Inhibitor - CAS 285986-31-4 - Calbiochem
Purity
The STAT5 Inhibitor, also referenced under CAS 285986-31-4, controls the biological activity of STAT5.
Packaging
10MG
Price
$148
Updated
2024/03/01
Cayman Chemical
Product number
15784
Product name
STAT5 Inhibitor
Purity
≥95%
Packaging
5mg
Price
$68
Updated
2024/03/01
Cayman Chemical
Product number
15784
Product name
STAT5 Inhibitor
Purity
≥95%
Packaging
10mg
Price
$130
Updated
2024/03/01
Cayman Chemical
Product number
15784
Product name
STAT5 Inhibitor
Purity
≥95%
Packaging
25mg
Price
$286
Updated
2024/03/01
ApexBio Technology
Product number
C4105
Product name
STAT5Inhibitor
Packaging
25mg
Price
$324
Updated
2021/12/16
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STAT5 Inhibitor Chemical Properties,Usage,Production

Description

Signal Transducers and Activators of Transcriptions (STATs) are a family of cytoplasmic latent transcription factors that are activated to regulate gene expression in response to a large number of extracellular signaling polypeptides including cytokines, interferons, and growth factors. STAT5, which consists of two isoforms STAT5α and STAT5β, is known to be overactive in several kinds of leukemias and various solid tumors. STAT5 Inhibitor is a cell-permeable, nonpetidic nicotinoyl hydrazone that suppresses STAT5 by targeting its SH2 domain (IC50 = 47 μM against STAT5β SH2 domain EPO peptide binding activity). Comparatively, this compound exhibits reduced potency towards inhibiting the SH2 domain of STAT1, STAT3, or Lck (IC50 > 500 μM). STAT5 Inhibitor has been shown to block STAT5/STAT5 DNA binding in K562 nuclear extracts.

Uses

2-?[(4-?Oxo-?4H-?1-?benzopyran-?3-?yl)?methylene]?hydrazide-3-?pyridinecarboxylic Acid is a selective inhibitor of STAT5.

Definition

ChEBI: A carbohydrazide that is nicotinohydrazide in which the terminal nitrogen has undergone formal condensation with the aldehyde group of 4-oxo-4H-chromene-3-carbaldehyde. It is an inhibitor of STAT5 (Signal Transducer and Activator of Tran cription 5) protein.

References

[1]. müller j, sperl b, reindl w, et al. discovery of chromone-based inhibitors of the transcription factor stat5. chembiochem. 2008 mar 25;9(5):723-7.
[2]. leonard wj, o'shea jj. jaks and stats: biological implications. annu rev immunol. 1998;16:293-322.
[3]. schindler c, darnell je jr. transcriptional responses to polypeptide ligands: the jak-stat pathway. annu rev biochem. 1995;64:621-51.

STAT5 Inhibitor Preparation Products And Raw materials

Raw materials

Preparation Products

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STAT5 Inhibitor Suppliers

China 68 India 1 United States 10 USA 1 Global 80
A.J Chemicals
Tel
--
Fax
--
Email
sales@ajchem.in
Country
India
ProdList
6100
Advantage
58

285986-31-4, STAT5 InhibitorRelated Search:


  • STAT5 Inhibitor
  • CS-2509
  • STAT5-IN-1
  • N'-[(4-oxo-4H-chromen-3-yl)methylene]nicotinohydrazide
  • STAT5 Inhibitor 1
  • (E)-N'-((4-oxo-4H-chromen-3-yl)methylene)nicotinohydrazide
  • MDK6314
  • 3-Pyridinecarboxylic acid, 2-[(4-oxo-4H-1-benzopyran-3-yl)methylene]hydrazide
  • STAT-5-IN-1,STAT5IN1,inhibit,STAT5 IN 1,Inhibitor,STAT
  • Stat5 Inhibitor(STAT5-IN-1)
  • N'3-[(4-oxo-4H-chromen-3-yl)methylidene]pyridine-3-carbohydrazide
  • N'-((4-Oxo-4H-chromen-3-yl)methylene)nicotinohydrazide
  • 3-{[(1E)-2-(pyridin-3-ylcarbonyl)diazanylidene]methyl}-4H-chromen-4-one
  • 285986-31-4