R788(Fostamatinib disodium)
- Product Name
- R788(Fostamatinib disodium)
- CAS No.
- 1025687-58-4
- Chemical Name
- R788(Fostamatinib disodium)
- Synonyms
- FosD;R 788 sodium;R788 disodium;R 935788 sodium;prodrug of R-406;Tamatinib Fosdium;Fo(R788) disodium;R788, Fostamatinib;R788 (sodium salt);FostaMatinib sodiuM
- CBNumber
- CB32518272
- Molecular Formula
- C23H27FN6NaO9P
- Formula Weight
- 604.46
- MOL File
- 1025687-58-4.mol
R788(Fostamatinib disodium) Property
- Melting point:
- >191°C (dec.)
- storage temp.
- Store at -20°C
- solubility
- DMSO (Slightly), Methanol (Slightly)
- form
- Solid
- color
- Off-White
- Stability:
- Hygroscopic
N-Bromosuccinimide Price
- Product number
- 18501
- Product name
- R788 (sodium salt)
- Purity
- ≥95%
- Packaging
- 1mg
- Price
- $44
- Updated
- 2024/03/01
- Product number
- 18501
- Product name
- R788 (sodium salt)
- Purity
- ≥95%
- Packaging
- 5mg
- Price
- $193
- Updated
- 2024/03/01
- Product number
- 18501
- Product name
- R788 (sodium salt)
- Purity
- ≥95%
- Packaging
- 10mg
- Price
- $341
- Updated
- 2024/03/01
- Product number
- SYN-1122-M010
- Product name
- R788disodiumsalt
- Purity
- ≥95%
- Packaging
- 10mg
- Price
- $324
- Updated
- 2021/12/16
- Product number
- CS-0427
- Product name
- FostamatinibDisodium
- Purity
- 99.88%
- Packaging
- 5mg
- Price
- $96
- Updated
- 2021/12/16
R788(Fostamatinib disodium) Chemical Properties,Usage,Production
Uses
R 788 Sodium Salt is the sodium salt of R 788 which is a selective spleen tyrosine kinase (Syk) inhibitor. It may be used in the treatment of autoimmune diseases such as type 1 diabetes and has been tested in the treatment of rheumatoid athritis, leukemia and lymphoma.
Biological Activity
r788, which is the prodrug of r406, is a potnet and selective syk inhibitor. the spleen tyrosine kinase (syk) plays a key role in the signaling of activating fc receptors and the b-cell receptor (bcr).
in vitro
r406 was found to induce the apoptosis of the majority of examined dlbcl cell lines and could specifically inhibit both tonic- and ligand-induced bcr signaling (autophosphorylation of syk525/526 and sykdependent phosphorylation of the b-cell linker protein [blnk]) [1].
in vivo
r788 effectively inhibits bcr signaling, demonstrating reduced proliferation and survival of the malignant b cells and significantly prolonged survival of the treated eμ-tcl1 transgenic mouse. moreover, the effect of r788 was found to be selective for the malignant clones, since no disturbance in the production of normal b lymphocytes was observed [2].
target
Syk
References
[1] chen l, monti s, juszczynski p, daley j, chen w, witzig te, habermann tm, kutok jl, shipp ma. syk-dependent tonic b-cell receptor signaling is a rational treatment target in diffuse large b-cell lymphoma. blood. 2008 feb 15;111(4):2230-7.
[2] suljagic m, longo pg, bennardo s, perlas e, leone g, laurenti l, efremov dg. the syk inhibitor fostamatinib disodium (r788) inhibits tumor growth in the eμ- tcl1 transgenic mouse model of cll by blocking antigen-dependent b-cell receptor signaling. blood. 2010 dec 2;116(23):4894-905.
[3] bajpai m. fostamatinib, a syk inhibitor prodrug for the treatment of inflammatory diseases. idrugs. 2009 mar;12(3):174-85.
R788(Fostamatinib disodium) Preparation Products And Raw materials
Raw materials
Preparation Products
R788(Fostamatinib disodium) Suppliers
View Lastest Price from R788(Fostamatinib disodium) manufacturers
- Product
- Fostamatinib disodium 1025687-58-4
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-06-26
- Product
- R788(Fostamatinib disodium) 1025687-58-4
- Price
- US $3.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2019-08-06