Description Clinical application Hazards Preparation
ChemicalBook > CAS DataBase List > 1,1,1,3,3,3-Hexafluoro-2-propanol

1,1,1,3,3,3-Hexafluoro-2-propanol

Description Clinical application Hazards Preparation
Product Name
1,1,1,3,3,3-Hexafluoro-2-propanol
CAS No.
920-66-1
Chemical Name
1,1,1,3,3,3-Hexafluoro-2-propanol
Synonyms
HFP;HFIP;HFIPA;F6IPROH;Egg mix;Fritters;Cold king;Pork ribs;HFIP 99.9%;Oil powder
CBNumber
CB3251829
Molecular Formula
C3H2F6O
Formula Weight
168.04
MOL File
920-66-1.mol
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1,1,1,3,3,3-Hexafluoro-2-propanol Property

Melting point:
−4 °C(lit.)
Boiling point:
59 °C(lit.)
Density 
1.596 g/mL at 25 °C(lit.)
vapor pressure 
269 hPa (30 °C)
refractive index 
n20/D 1.275(lit.)
Flash point:
4,4°C
storage temp. 
Store below +30°C.
form 
Solid
pka
pK1:9.42 (25°C)
Specific Gravity
1.596
color 
White to yellow
PH
3-4 (H2O)Aqueous solution
Water Solubility 
1000 g/L (25 ºC)
λmax
229nm(lit.)
BRN 
1841007
Stability:
Stable. Incompatible with strong acids, strong bases, alkali metals.
InChIKey
BYEAHWXPCBROCE-UHFFFAOYSA-N
CAS DataBase Reference
920-66-1(CAS DataBase Reference)
NIST Chemistry Reference
2-Propanol, 1,1,1,3,3,3-hexafluoro-(920-66-1)
EPA Substance Registry System
1,1,1,3,3,3-Hexafluoro-2-propanol (920-66-1)
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Safety

Hazard Codes 
C,Xi
Risk Statements 
20/22-34
Safety Statements 
26-36/37/39-45-27
RIDADR 
UN 2922 8/PG 2
WGK Germany 
2
RTECS 
UB6450000
27
Hazard Note 
Corrosive
TSCA 
T
HazardClass 
8
PackingGroup 
II
HS Code 
29055910
Toxicity
LD50 orally in Rabbit: 1500 mg/kg
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H302Harmful if swallowed

H314Causes severe skin burns and eye damage

H318Causes serious eye damage

H332Harmful if inhaled

H361Suspected of damaging fertility or the unborn child

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P330+P331IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
105228
Product name
1,1,1,3,3,3-Hexafluoro-2-propanol
Purity
≥99%
Packaging
5g
Price
$55.9
Updated
2020/08/18
Sigma-Aldrich
Product number
8.04515
Product name
1,1,1,3,3,3-Hexafluoro-2-propanol
Purity
for synthesis
Packaging
25 mL
Price
$111
Updated
2021/03/22
Sigma-Aldrich
Product number
8.04515
Product name
1,1,1,3,3,3-Hexafluoro-2-propanol
Purity
for synthesis
Packaging
100 mL
Price
$346.87
Updated
2021/03/22
Sigma-Aldrich
Product number
8.04515
Product name
1,1,1,3,3,3-Hexafluoro-2-propanol
Purity
for synthesis
Packaging
1 L
Price
$1119.25
Updated
2021/03/22
Sigma-Aldrich
Product number
105228
Product name
1,1,1,3,3,3-Hexafluoro-2-propanol
Purity
≥99%
Packaging
2kg
Price
$2030
Updated
2020/08/18
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1,1,1,3,3,3-Hexafluoro-2-propanol Chemical Properties,Usage,Production

Description

Hexafluoroisopropanol (HFIP) is a viscous and colorless liquid with scary odorless. It is an ideal solvent for dissolving polyamides and esters, and it can be used to analyze nylon. Typically, a small amount of sodium trifluoroacetate can be added to the eluent to reduce the aggregation of the sample. HFIP has a certain viscosity, but its boiling point is very low, so we need to analyst under the conditions of 40 ° C to reduce the back pressure of the column. Hexafluoroisopropanol is also a highly polar solvent that results in a non-linearity of the calibration curve obtained from the mixed column bed column. Therefore, Agilent has developed a special column-PL HFIPgel column for this solvent, which has a porous structure that is not affected by solvents.

Clinical application

Hexafluoroisopropanol(1,1,1,3,3,3-Hexafluoro-2-propanol) can be used to prepare a variety of high-end chemicals such as fluorosurfactants, fluorine-containing emulsifiers, fluorine-containing pharmaceuticals, and used as a solvent or cleaning agent for electronics industry.
The drug can be used as a fluorinated solvent to increase the efficiency of the reaction of rhodium (I)-catalyzed [4 + 2] intramolecular addition reaction of ether bound alkynyl diene and the [5 + 2] cycloaddition of alkynyl vinyl cyclopropane. The drug is a liquid peptide chemical solvent, a highly soluble solvent for peptide and peptide intermediates. The drug can be used for the analysis of multiple polymers.

Hazards

1,1,1,3,3,3-Hexafluoro-2-propanol derives from a propan-2-ol. It is a clear colorless oily liquid with an aromatic odor. (NTP, 1992) Combustible, may cause burns to skin, eyes and mucous membranes.

Preparation

1,1,1,3,3,3-Hexafluoro-2-propanol is prepared from hexafluoropropylene through hexafluoroacetone, which is then hydrogenated.
(CF3)2CO + H2 → (CF3)2CHOH

Chemical Properties

1,1,1,3,3,3-Hexafluoro-2-propanol (HFIP) is a clear, colorless, oily, combustible liquid. Odor is described as aromatic.

Chemical Properties

Colorless liquid

Uses

Hexafluoroisopropanol is used to produce high-end chemicals, such as fluorinated surfactants, fluorinated emulsifier and fluorinated medicine, etc. HFIP is used as a solvent or cleaner in electronic industry.

Uses

1,1,1,3,3,3-Hexafluoro-2-propanol effects the native state of proteins, denaturing them as well as stabilizing the α-helical conformation of unfolded proteins and polypeptides.

Uses

It is used as a polar solvent and exhibits strong hydrogen bonding properties.It dissolves substances that are hydrogen-bond acceptors, such as amides, ethers and a wide range of polymers, including those that are not soluble in the most common organic solvents.

Uses

Usually used for preparing hexafluoroalcohol-functionalized methacrylate polymers for lithographic/nanopatterning materials.

Definition

ChEBI: An organofluorine compound formed by substitution of all the methyl protons in propan-2-ol by fluorine. It is a metabolite of inhalation anesthetic sevoflurane.

Air & Water Reactions

Water soluble.

Reactivity Profile

1,1,1,3,3,3-Hexafluoro-2-propanol is incompatible with acids, acid chlorides and oxidizing agents.

Fire Hazard

1,1,1,3,3,3-Hexafluoro-2-propanol is probably combustible.

Potential Exposure

A specialty solvent for some poly mers; a lavatory reagent.

Shipping

UN1760 Corrosive liquids, n.o.s., Hazard class: 8; Labels: 8-Corrosive material.

Purification Methods

Distil it from 3A molecular sieves, retaining the middle fraction. It has been prepared by reduction of hexafluoroacetone in tetrahydrofuran (THF), In this case hexafluoropropanol forms a stable 1:1 complex which distils at 99-100o/760mm (n 25 1.3283), The complex is decomposed by mixing with 20% oleum and distilling in a vacuum, and the distillate is redistilled to give pure hexafluoropropan-2-ol with b 59o/760mm. The 1H NMR shows a doublet at 4.52ppm (JH,H 2Hz). The benzoyl derivative, [10315-85-2] M 272.1, has m 53.9o after crystalllisation from pentane at -50o, and its IR has at 1760cm-1. [Middleton & Lindsey J Am Chem Soc 86 4948 1964, Urry et al. J Org Chem 32 347 1967.] It has very high peptide solubilising properties, alone or with CH2Cl2 [use as a solvent: Narita et al. Bull Chem Soc Jpn 61 281 1988, Biochemistry 29 2639 1990.] It is CORROSIVE, causes severe eye irritation.

Incompatibilities

HFIP is incompatible with acids, acid chlorides, and oxidizing agents.

Waste Disposal

May be incinerated. In accor dance with 40CFR165, follow recommendations for the disposal of pesticides and pesticide containers. Must be dis posed properly by following package label directions or by contacting your local or federal environmental control agency, or by contacting your regional EPA office. Consult with environmental regulatory agencies for guidance on acceptable disposal practices. Generators of waste contain ing this contaminant (≥100 kg/mo) must conform to EPA regulations governing storage, transportation, treatment, and waste disposal.

1,1,1,3,3,3-Hexafluoro-2-propanol Preparation Products And Raw materials

Raw materials

Preparation Products

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1,1,1,3,3,3-Hexafluoro-2-propanol Suppliers

Jinan Finer Chemical Co., Ltd
Fax
0531-88989539
Email
sales@finerchem.com
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China
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HANGZHOU HETE CHEMICAL TECHNOLOGY CO.,LTD
Tel
+86-571 89189769;15168342188
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+86-571-86205065
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China
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Ji'nan Langhua Chemical Co. Ltd.
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0531-85906691
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+86-0531-85906692
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325912680@qq.com
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Shanghai Aladdin Bio-Chem Technology Co.,LTD
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021-20337333-801
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021-50323701
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market@aladdin-e.com
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Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.
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025-66099280-
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(1)02557626880
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cfzhang@aikonchem.com
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Meryer (Shanghai) Chemical Technology Co., Ltd.
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21-61259100-
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86-21-61259102
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sh@meryer.com
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Shanghai Jinghui Industrial Co., Ltd.
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021-52961116-
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info@vlchem.cn
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Shangfluoro
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Energy Chemical
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021-58432009-
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021-58436166
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sales8178@energy-chemical.com
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Creasyn Finechem(Tianjin) Co., Ltd.
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022-83945878-
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022-83945176
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export@creasyn.com
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View Lastest Price from 1,1,1,3,3,3-Hexafluoro-2-propanol manufacturers

Jinan Finer Chemical Co., Ltd
Product
1,1,1,3,3,3-Hexafluoro-2-propanol 920-66-1
Price
US $0.00/kg
Min. Order
1kg
Purity
99.5%
Supply Ability
500mt
Release date
2019-03-15
Wuhan Mulei New Material Technology Co. Ltd
Product
Hexafluoroisopropanol 920-66-1
Price
US $20.00/Kg/Drum
Min. Order
25Kg/Drum
Purity
99.99%
Supply Ability
1 ton per week
Release date
2021-04-02
Hebei Crovell Biotech Co Ltd
Product
Hexafluoroisopropanol 920-66-1
Price
US $5.60/KG
Min. Order
1KG
Purity
99.5%
Supply Ability
5000kg
Release date
2021-07-12

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