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Sevoflurane

Product Name
Sevoflurane
CAS No.
28523-86-6
Chemical Name
Sevoflurane
Synonyms
FLUOROMETHYL 1,1,1,3,3,3-HEXAFLUOROISOPROPYL ETHER;mr6s4;Ultane;R-E 347;Sevoness;347mmzEbg;Sevofrane;Qi Fu Wan;Sevofurane;SEVOFLURANE
CBNumber
CB1440979
Molecular Formula
C4H3F7O
Formula Weight
200.05
MOL File
28523-86-6.mol
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Sevoflurane Property

Melting point:
<25 °C
Boiling point:
58°C
Density 
1.505
Flash point:
58°C
storage temp. 
Refrigerator
solubility 
Slightly soluble in water, miscible with ethanol (96 per cent).
Specific Gravity
1.505
color 
Colourless
Water Solubility 
Slightly miscible with water.
Merck 
14,8475
BRN 
2041023
InChIKey
DFEYYRMXOJXZRJ-UHFFFAOYSA-N
CAS DataBase Reference
28523-86-6(CAS DataBase Reference)
EPA Substance Registry System
Propane,1,1,1,3,3,3-hexafluoro-2-(fluoromethoxy)- (28523-86-6)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38-36/38
Safety Statements 
26-36/37/39-36/37-23
RIDADR 
UN 3334
WGK Germany 
3
RTECS 
KO0737000
Hazard Note 
Irritant
HS Code 
29091990
Hazardous Substances Data
28523-86-6(Hazardous Substances Data)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
Y0001993
Product name
Sevoflurane for system suitability
Purity
European Pharmacopoeia (EP) Reference Standard
Packaging
Y0001993
Price
$149
Updated
2024/03/01
Sigma-Aldrich
Product number
Y0001046
Product name
Sevoflurane
Purity
European Pharmacopoeia (EP) Reference Standard
Packaging
y0001046
Price
$220
Updated
2024/03/01
Sigma-Aldrich
Product number
PHR3348
Product name
Sevoflurane
Purity
certified reference material, pharmaceutical secondary standard
Packaging
1ML
Price
$228
Updated
2024/03/01
Sigma-Aldrich
Product number
1612540
Product name
Sevoflurane
Packaging
1ml
Price
$436
Updated
2024/03/01
TCI Chemical
Product number
F0691
Product name
Fluoromethyl 1,1,1,3,3,3-Hexafluoroisopropyl Ether
Purity
>98.0%(GC)
Packaging
5g
Price
$202
Updated
2024/03/01
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Sevoflurane Chemical Properties,Usage,Production

Description

Sevoflurane is a rapidly acting, potent inhalation anesthetic with rapid uptake and and elimination. While somewhat less potent than halothane, sevoflurane does not induce arrhythmias and reportedly has no effect on renal function.

Description

Sevoflurane is a halogenated ether with anesthetic properties. It enhances the activity of GABAA and glycine receptors and inhibits the activity of nicotinic acetylcholine receptors (nAChRs) and glutamate receptors. Sevoflurane enhances the responses of α2β1 subunit-containing GABAA and α1 subunit-containing glycine receptors at submaximal agonist concentrations in HEK293 cells (EC50s = 0.45 and 0.36 mM, respectively). Sevoflurane (360 μM) also increases the amplitude of GABAA receptor responses to GABA stimulation for receptors with an α1β2γ2 subunit composition. It inhibits binding of the high affinity nicotinic agonist epibatidine to nAChRs in mouse brain membranes (IC50 = 0.77 mM). Formulations containing sevoflurane have been used in the induction and maintenance of general anesthesia.

Chemical Properties

Clear, colourless, volatile liquid.

Originator

Baxter (USA)

Uses

1,1,1,3,3,3-Hexafluoro-2-(fluoromethoxy)propane is an volatile anesthetic which inhibited activation of inflammatory neutrophil and granulocyte in human blood during simulated extracorporeal circulati on.

Uses

Fluoromethyl 1,1,1,3,3,3-hexafluoroisopropyl ether is a volatile anesthetic, which inhibits the activation of inflammatory neutrophil and granulocyte in human blood during simulated extracorporeal circulation. It also serves as an antibacterial and used as an inhalational anaesthetic for induction and maintenance of general anesthesia. Further, it finds application in anesthesia of children and infants to make them asleep for surgery. In addition to this, it is used in veterinary medicine.

Definition

ChEBI: An ether compound having fluoromethyl and 1,1,1,3,3,3-hexafluoroisopropyl as the two alkyl groups.

Manufacturing Process

164 g (2.31 mole) of chlorine is slowly bubbled into a flask containing 370 g (2.03 mole) of methyl 1,1,1,3,3,3-hexafluoroisopropyl ether illuminated with a 250 watt incandescent lamp, starting at room temperature. The product is washed with a potassium carbonate solution until neutral, dried over MgSO4 and vacuum distilled to yield 304 g (1.5 mole) of chloromethyl 1,1,1,3,3,3- hexafluoroisopropyl ether (chloromethyl 1,1,1,3,3,3-hexafluoro-2-propyl ether), boiling point 78°C.
A solution of chloromethyl 1,1,1,3,3,3-hexafluoro-2-propyl ether (754 g, 3.49 moles) in dry tetrahydrothiophene 1,1-dioxide (203 g, 3,49 moles) were stirred and heated to 130°C in a creased flask fitted with a fractional distillation assembly. A distillate (200 ml), b748 56.0° to 62°C, was collected during 5 h. Then the reaction mixture was cooled to room temperature, dry potassium fluoride (100 g, 1.74 moles) was added, and the cycle of operations was repeated 3 times at temperatures between 138° to 185°C to give distillates (100 ml, 100 ml and 50 ml), b746 58° to 61°C, 55.5° to 57°C, and 54.2° to 55.9°C, respectively. From this portionwise addition of potassium fluoride (503 g, 8.7 moles) there was obtained distillates totalling 672 g, b746 54.2° to 62.0°C, which by GLC analysis was about 92% fluoromethyl and 6.8% chloromethyl 1,1,1,3,3,3-hexafluoro-2-propyl ether.
Fractional distillation of 659 g gave a forerun (46 g), b745 53.5° to 57.0°C, and then 99.6% pure fluoromethyl 1,1,1,3,3,3-hexafluoro-2-propyl ether (505 g), b745 57.0° to 57.7°C.

brand name

Ultane (Abbott);Sevofrane.

Therapeutic Function

Anesthetic

Biological Functions

Sevoflurane (Ultane) is the most recently introduced inhalation anesthetic. It has low tissue and blood solubility, which allows for rapid induction and emergence and makes it useful for outpatient and ambulatory procedures. It has the advantage of not being pungent, a characteristic that permits a smooth inhalation induction, and is particularly useful in pediatric anesthesia.
Hypotension is produced by sevoflurane as systemic vasodilation occurs and cardiac output decreases. Since it does not directly produce tachycardia, it is a useful alternative to consider in patients with myocardial ischemia. However, a concern for reflex-induced tachycardia remains.
Sevoflurane undergoes hepatic biotransformation (about 3% of the inhaled dose), and it is somewhat degraded by conventional CO2 absorbents. The degradation product from the absorbent has been reported to be nephrotoxic, although the report is controversial and not substantiated by more recent studies. Sevoflurane’s actions on skeletal muscle and on vascular regulation within the CNS are similar to those described for the other halogenated hydrocarbon anesthetics.

General Description

Sevoflurane is a volatile, nonpungent, nonflammable, andnonexplosive liquid with a boiling point of 58.6°C. Theblood:gas partition coefficient is 0.65, the oil:gas partitioncoefficient is 50, and the MAC is 2.1%. Sevoflurane reactswith desiccated carbon dioxide adsorbents, to produce compounds(A and B) with known toxicity . The typeof CO2 absorbent used, the temperature of the absorbent,and the duration of exposure can influence the degree towhich sevoflurane breaks down. The major breakdownproduct, compound A, pentafluoroisopropenyl fluoromethylether, (PIFE, C4H2F6O) has been studied extensively.Compound A is nephrotoxic in rats and nonhuman primatesand remains a theoretical risk to humans. As discussedpreviously under the stability of inhaled anesthetics,sevoflurane breakdown by CO2 absorbents generates heatand has resulted in sporadic operating room fires.

Clinical Use

Sevoflurane has been shown to cause epileptic changeson EEGs and case reports of seizures during surgery, especiallyin children, have been reported.

Veterinary Drugs and Treatments

Sevoflurane may be useful in a variety of species when rapid induction and/or rapid recoveries are desired with an inhalational anesthetic.

Sevoflurane Preparation Products And Raw materials

Raw materials

Preparation Products

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Sevoflurane Suppliers

SHANG FLUORO
Tel
021-65170832 15601903708
Email
qinba_1@163.com
Country
China
ProdList
374
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60
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
94657
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Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
021-61259108 18621169109
Fax
86-21-61259102
Email
market03@meryer.com
Country
China
ProdList
40228
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Alfa Aesar
Tel
400-6106006
Fax
021-67582001/03/05
Email
saleschina@alfa-asia.com
Country
China
ProdList
30123
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TCI (Shanghai) Development Co., Ltd.
Tel
021-67121386
Fax
021-67121385
Email
Sales-CN@TCIchemicals.com
Country
China
ProdList
24529
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Beijing HwrkChemical Technology Co., Ltd
Tel
010-89508211 18501085097
Fax
010-89508210
Email
sales.bj@hwrkchemical.com
Country
China
ProdList
8418
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Pure Chemistry Scientific Inc.
Tel
001-857-928-2050 or 1-888-588-9418
Fax
001-617-206-9595
Email
sales@chemreagents.com
Country
United States
ProdList
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LGM Pharma
Tel
1-(800)-881-8210
Fax
615-250-9817
Email
inquiries@lgmpharma.com
Country
United States
ProdList
2123
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70
Shanghai Longsheng chemical Co.,Ltd.
Tel
021-58099652-8005 13585536065
Fax
021-58099609
Email
bin.wu@shlschem.com
Country
China
ProdList
9809
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Chemsky(shanghai)International Co.,Ltd.
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
32321
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View Lastest Price from Sevoflurane manufacturers

Hangzhou Hyper Chemicals Limited
Product
Sevoflurane 28523-86-6
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
USP
Supply Ability
100kg
Release date
2024-05-31
Xiamen Wonderful Bio Technology Co., Ltd.
Product
sevoflurane 28523-86-6
Price
US $15.00/KG
Min. Order
1250KG
Purity
99.8%
Supply Ability
330T
Release date
2023-07-21
Henan Bao Enluo International TradeCo.,LTD
Product
Sevoflurane 28523-86-6
Price
US $50.00/kg
Min. Order
1kg
Purity
99.9%
Supply Ability
10000MT
Release date
2023-07-25

28523-86-6, SevofluraneRelated Search:


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