Sevoflurane

ChemicalBook > CAS DataBase List > Sevoflurane

Product Name: Sevoflurane
CAS No.: 28523-86-6
Chemical Name: Sevoflurane
Synonyms: FLUOROMETHYL 1,1,1,3,3,3-HEXAFLUOROISOPROPYL ETHER;mr6s4;Ultane;R-E 347;Sevoness;347mmzEbg;Sevofrane;Qi Fu Wan;SEVOFLURANE;Seven halothane
CBNumber: CB1440979
Molecular Formula: C4H3F7O
Formula Weight: 200.05
MOL File: 28523-86-6.mol

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Sevoflurane Property

Melting point:: <25 °C
Boiling point:: 58°C
Density: 1.505
Flash point:: 58°C
storage temp.: Refrigerator
solubility: Slightly soluble in water, miscible with ethanol (96 per cent).
Specific Gravity: 1.505
color: Colourless
Water Solubility: Slightly miscible with water.
Merck: 14,8475
BRN: 2041023
InChIKey: DFEYYRMXOJXZRJ-UHFFFAOYSA-N
CAS DataBase Reference: 28523-86-6(CAS DataBase Reference)
EPA Substance Registry System: Propane,1,1,1,3,3,3-hexafluoro-2-(fluoromethoxy)- (28523-86-6)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38-36/38
Safety Statements: 26-36/37/39-36/37-23
RIDADR: UN 3334
WGK Germany: 3
RTECS: KO0737000
Hazard Note: Irritant
HS Code: 29091990
Hazardous Substances Data: 28523-86-6(Hazardous Substances Data)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: Y0001993
Product name: Sevoflurane for system suitability
Purity: European Pharmacopoeia (EP) Reference Standard
Packaging: Y0001993
Price: $149
Updated: 2024/03/01

Sigma-Aldrich

Product number: Y0001046
Product name: Sevoflurane
Purity: European Pharmacopoeia (EP) Reference Standard
Packaging: y0001046
Price: $220
Updated: 2024/03/01

Sigma-Aldrich

Product number: PHR3348
Product name: Sevoflurane
Purity: certified reference material, pharmaceutical secondary standard
Packaging: 1ML
Price: $228
Updated: 2024/03/01

Sigma-Aldrich

Product number: 1612540
Product name: Sevoflurane
Packaging: 1ml
Price: $436
Updated: 2024/03/01

TCI Chemical

Product number: F0691
Product name: Fluoromethyl 1,1,1,3,3,3-Hexafluoroisopropyl Ether
Purity: >98.0%(GC)
Packaging: 5g
Price: $202
Updated: 2024/03/01

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Sevoflurane Chemical Properties,Usage,Production

Description

Sevoflurane is a rapidly acting, potent inhalation anesthetic with rapid uptake and and elimination. While somewhat less potent than halothane, sevoflurane does not induce arrhythmias and reportedly has no effect on renal function.

Description

Sevoflurane is a halogenated ether with anesthetic properties. It enhances the activity of GABA_A and glycine receptors and inhibits the activity of nicotinic acetylcholine receptors (nAChRs) and glutamate receptors. Sevoflurane enhances the responses of α₂β₁ subunit-containing GABA_A and α₁ subunit-containing glycine receptors at submaximal agonist concentrations in HEK293 cells (EC₅₀s = 0.45 and 0.36 mM, respectively). Sevoflurane (360 μM) also increases the amplitude of GABA_A receptor responses to GABA stimulation for receptors with an α₁β₂γ₂ subunit composition. It inhibits binding of the high affinity nicotinic agonist epibatidine to nAChRs in mouse brain membranes (IC₅₀ = 0.77 mM). Formulations containing sevoflurane have been used in the induction and maintenance of general anesthesia.

Chemical Properties

Clear, colourless, volatile liquid.

Originator

Baxter (USA)

Uses

1,1,1,3,3,3-Hexafluoro-2-(fluoromethoxy)propane is an volatile anesthetic which inhibited activation of inflammatory neutrophil and granulocyte in human blood during simulated extracorporeal circulati on.

Uses

Fluoromethyl 1,1,1,3,3,3-hexafluoroisopropyl ether is a volatile anesthetic, which inhibits the activation of inflammatory neutrophil and granulocyte in human blood during simulated extracorporeal circulation. It also serves as an antibacterial and used as an inhalational anaesthetic for induction and maintenance of general anesthesia. Further, it finds application in anesthesia of children and infants to make them asleep for surgery. In addition to this, it is used in veterinary medicine.

Definition

ChEBI: An ether compound having fluoromethyl and 1,1,1,3,3,3-hexafluoroisopropyl as the two alkyl groups.

Manufacturing Process

164 g (2.31 mole) of chlorine is slowly bubbled into a flask containing 370 g (2.03 mole) of methyl 1,1,1,3,3,3-hexafluoroisopropyl ether illuminated with a 250 watt incandescent lamp, starting at room temperature. The product is washed with a potassium carbonate solution until neutral, dried over MgSO4 and vacuum distilled to yield 304 g (1.5 mole) of chloromethyl 1,1,1,3,3,3- hexafluoroisopropyl ether (chloromethyl 1,1,1,3,3,3-hexafluoro-2-propyl ether), boiling point 78°C.
A solution of chloromethyl 1,1,1,3,3,3-hexafluoro-2-propyl ether (754 g, 3.49 moles) in dry tetrahydrothiophene 1,1-dioxide (203 g, 3,49 moles) were stirred and heated to 130°C in a creased flask fitted with a fractional distillation assembly. A distillate (200 ml), b748 56.0° to 62°C, was collected during 5 h. Then the reaction mixture was cooled to room temperature, dry potassium fluoride (100 g, 1.74 moles) was added, and the cycle of operations was repeated 3 times at temperatures between 138° to 185°C to give distillates (100 ml, 100 ml and 50 ml), b746 58° to 61°C, 55.5° to 57°C, and 54.2° to 55.9°C, respectively. From this portionwise addition of potassium fluoride (503 g, 8.7 moles) there was obtained distillates totalling 672 g, b746 54.2° to 62.0°C, which by GLC analysis was about 92% fluoromethyl and 6.8% chloromethyl 1,1,1,3,3,3-hexafluoro-2-propyl ether.
Fractional distillation of 659 g gave a forerun (46 g), b745 53.5° to 57.0°C, and then 99.6% pure fluoromethyl 1,1,1,3,3,3-hexafluoro-2-propyl ether (505 g), b745 57.0° to 57.7°C.

brand name

Ultane (Abbott);Sevofrane.

Therapeutic Function

Anesthetic

Biological Functions

Sevoflurane (Ultane) is the most recently introduced inhalation anesthetic. It has low tissue and blood solubility, which allows for rapid induction and emergence and makes it useful for outpatient and ambulatory procedures. It has the advantage of not being pungent, a characteristic that permits a smooth inhalation induction, and is particularly useful in pediatric anesthesia.
Hypotension is produced by sevoflurane as systemic vasodilation occurs and cardiac output decreases. Since it does not directly produce tachycardia, it is a useful alternative to consider in patients with myocardial ischemia. However, a concern for reflex-induced tachycardia remains.
Sevoflurane undergoes hepatic biotransformation (about 3% of the inhaled dose), and it is somewhat degraded by conventional CO₂ absorbents. The degradation product from the absorbent has been reported to be nephrotoxic, although the report is controversial and not substantiated by more recent studies. Sevoflurane’s actions on skeletal muscle and on vascular regulation within the CNS are similar to those described for the other halogenated hydrocarbon anesthetics.

General Description

Sevoflurane is a volatile, nonpungent, nonflammable, andnonexplosive liquid with a boiling point of 58.6°C. Theblood:gas partition coefficient is 0.65, the oil:gas partitioncoefficient is 50, and the MAC is 2.1%. Sevoflurane reactswith desiccated carbon dioxide adsorbents, to produce compounds(A and B) with known toxicity . The typeof CO₂ absorbent used, the temperature of the absorbent,and the duration of exposure can influence the degree towhich sevoflurane breaks down. The major breakdownproduct, compound A, pentafluoroisopropenyl fluoromethylether, (PIFE, C₄H₂F₆O) has been studied extensively.Compound A is nephrotoxic in rats and nonhuman primatesand remains a theoretical risk to humans. As discussedpreviously under the stability of inhaled anesthetics,sevoflurane breakdown by CO₂ absorbents generates heatand has resulted in sporadic operating room fires.

Clinical Use

Sevoflurane has been shown to cause epileptic changeson EEGs and case reports of seizures during surgery, especiallyin children, have been reported.

Veterinary Drugs and Treatments

Sevoflurane may be useful in a variety of species when rapid induction and/or rapid recoveries are desired with an inhalational anesthetic.

Sevoflurane Preparation Products And Raw materials

Raw materials

Hexafluoroacetone 1,1,1,3,3,3-Hexafluoro-2-propanol Bromoacetic acid Hydrogen fluoride

Preparation Products

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View Lastest Price from Sevoflurane manufacturers

Hebei Duling International Trade Co. LTD

Product: Sevoflurane 28523-86-6
Price: US $50.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 20 tons
Release date: 2023-03-27

Xiamen Wonderful Bio Technology Co., Ltd.

Product: sevoflurane 28523-86-6
Price: US $15.00/KG
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Purity: 99.8%
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Release date: 2023-07-21

Henan Bao Enluo International TradeCo.，LTD

Product: Sevoflurane 28523-86-6
Price: US $50.00/kg
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Supply Ability: 10000MT
Release date: 2023-07-25

28523-86-6, SevofluraneRelated Search:

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mr6s4

FLUOROMETHYL 1,1,1,3,3,3-HEXAFLUOROISOPROPYL ETHER

Fluoromethyl 1-(trifluoromethyl)-2,2,2-trifluoroethyl ether

Sevoness

347mmzEbg

Ether, fluoromethyl 2,2,2-trifluoro-1-(trifluoromethyl)ethyl (8CI)

Fluoromethyl 1,1,1,3,3,3-hexafluoro-2-propyl ether

Propane, 1,1,1,3,3,3-hexafluoro-2-(fluoromethoxy)- (9CI)

R-E 347

Sevofrane

Ultane

Fluoromethyl 1,1,1,3,3,3-hexafluoroisopropyl ether, 98+%

1,1,1,3,3,3-HEXAFLUOROISOPROPYL FLUOROMETHYL ETHER

1,1,1,3,3,3-HEXAFLUORO-2-(FLUOROMETHOXY)PROPANE

Fluoromethy 2，2，2-trifluoro-1-(trifluoromethyl)ethyl ether

Sevoflurane (1 mL)

1H,1H,3H-Perfluoro(3-methyl-2-oxabutane)

1,1,1,3,3,3-Hexafluoro-2-(fluoromethoxy)propane, Fluoromethyl 1,1,1,3,3,3-hexafluoroisopropyl ether, Sevoflurane

2-(Fluoromethoxy)-1,1,1,3,3,3-hexafluoropropane, 1,1,1,4-Tetrafluoro-2-(trifluoromethyl)-3-oxabutane, Sevoflurane

Fluoromethyl 2H-hexafluoroprop-2-yl ether

Propane,1,1,1,3,3,3-hexafluoro-2-(fluoroMethoxy)-

Qi Fu Wan

SEVOFLURANE

1,1,1,3,3,3-hexafluoro-2-(fluoromethoxy)-propan

fluoromethyl2,2,2-trifluoro-1-(trifluoromethyl)ethyl-ethe

fluoromethyl2,2,2-trifluoro-1-(trifluoromethyl)ethylether

Fluoromethyl 1,1,1,3,3,3-hexafluoroisopropyl ether (Sevoflurane)

1,1,1,3,3,3-Hexafluoroisopropyl Ether

Seven halothane

Sevoflurane USP/EP/BP

Sevoflurane (1612540)

28523-86-6

28532-86-6

C4H3OF7

CF32CHOCH2F

ZYVOX

Fluoro series