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Isoflurane

Product Name
Isoflurane
CAS No.
26675-46-7
Chemical Name
Isoflurane
Synonyms
Forane;Forene;Aerrane;Isourane;r-e235dal;Compd 469;R-E 235da1;ISOFLURANE;HCFE 235da2;ISOFLUORENE
CBNumber
CB8437691
Molecular Formula
C3H2ClF5O
Formula Weight
184.49
MOL File
26675-46-7.mol
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Isoflurane Property

Melting point:
48.5°C
Boiling point:
49 °C
Density 
1.45
vapor pressure 
238 mmHg ( 20 °C)
refractive index 
1.3002
Flash point:
48-49°C
solubility 
Practically insoluble in water, miscible with ethanol and trichloroethylene.
form 
neat
Specific Gravity
approximate 1.50
Water Solubility 
Soluble in chloroform and ethyl acetate. Not miscible or difficult to mix in water.
Merck 
14,5175
BRN 
1852087
Stability:
Stable.
InChIKey
PIWKPBJCKXDKJR-UHFFFAOYSA-N
CAS DataBase Reference
26675-46-7(CAS DataBase Reference)
NIST Chemistry Reference
1-Chloro-2,2,2-trifluoroethyl difluoromethyl ether(26675-46-7)
EPA Substance Registry System
Ethane, 2-chloro-2-(difluoromethoxy)- 1,1,1-trifluoro-(26675-46-7)
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Safety

Hazard Codes 
F,T,Xn
Risk Statements 
36/37/38-67-48/20
Safety Statements 
26-36/37/39-24/25
RIDADR 
UN 3334
WGK Germany 
3
RTECS 
KN6799000
Hazard Note 
Flammable/Toxic
HS Code 
2909191800
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

H336May cause drowsiness or dizziness

H371May cause damage to organs

H373May cause damage to organs through prolonged or repeated exposure

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
792632
Product name
Isoflurane
Packaging
1g
Price
$97.7
Updated
2018/11/13
Sigma-Aldrich
Product number
1349003
Product name
Isoflurane
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
1ml
Price
$348
Updated
2018/11/13
TCI Chemical
Product number
C2485
Product name
1-Chloro-2,2,2-trifluoroethyl Difluoromethyl Ether
Purity
>98.0%(GC)
Packaging
5g
Price
$45
Updated
2018/11/22
TCI Chemical
Product number
C2485
Product name
1-Chloro-2,2,2-trifluoroethyl Difluoromethyl Ether
Purity
>98.0%(GC)
Packaging
25g
Price
$133
Updated
2018/11/22
Alfa Aesar
Product number
L17315
Product name
1-Chloro-2,2,2-trifluoroethyl difluoromethyl ether, 97%
Packaging
25g
Price
$142
Updated
2018/11/13
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Isoflurane Chemical Properties,Usage,Production

Chemical Properties

colourless liquid

Uses

Isoflurane is a halogenated ether used for inhalational anesthesia. Recent studies suggest that there might be a relationship between administration of isoflurane and postoperative cognitive dysfunct ion (POCD).

Uses

Solvent and dispersant for fluorinated materials.

brand name

Forane (Baxter Healthcare).

Biological Functions

Isoflurane (Forane) is a structural isomer of enflurane and produces similar pharmacological properties: some analgesia, some neuromuscular blockade, and depressed respiration. In contrast, however, isoflurane is considered a particularly safe anesthetic in patients with ischemic heart disease, since cardiac output is maintained, the coronary arteries are dilated, and the myocardium does not appear to be sensitized to the effects of catecholamines. Also, blood pressure falls as a result of vasodilation, which preserves tissue blood flow. Isoflurane causes transient and mild tachycardia by direct sympathetic stimulation; this is particularly important in the management of patients with myocardial ischemia.
Unlike enflurane, isoflurane does not produce a seizurelike EEG pattern. Furthermore, the metabolic transformation of isoflurane is only one-tenth that of enflurane, so fluoride production is quite low. Among the halogenated hydrocarbons, isoflurane is one of the most popular, since it preserves cardiovascular stability and causes a low incidence of untoward effects.

General Description

Isoflurane is a volatile liquid (bp=48.5°C) with an MAC of1.15, a blood:gas partition coefficient of 1.43 and high solubilityin fat. Isoflurane is a structural isomer of enflurane. Itis a known respiratory irritant, but less so than desflurane.Approximately 0.2% of the administered drug undergoesmetabolism, the rest is exhaled unchanged. The metabolismof isoflurane yields low levels of the nephrotoxic fluoride ionas well as a potentially hepatotoxic trifluoroacetylating compound). The relatively low concentrations ofthese compounds have resulted in very low risks of hepatotoxicityand nephrotoxicity. There have been no reports ofseizures caused by isoflurane and only transient increases inheart rate have been reported.

Veterinary Drugs and Treatments

Isoflurane is an inhalant anesthetic that has some distinct advantages over either halothane or methoxyflurane due to its lessened myocardial depressant and catecholamine sensitizing effects, and the ability to use it safely in patients with either hepatic or renal disease. Isoflurane’s higher cost than either methoxyflurane or halothane is a disadvantage.
Horses may recover more rapidly than with halothane, but be more susceptible to anesthetic associated- myopathy.

Isoflurane Preparation Products And Raw materials

Raw materials

Preparation Products

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Isoflurane Suppliers

Lianyungang Xuanyuan Chemical Co., Ltd
Tel
+86-0518-85415818 18000194506
Fax
+86-0518-85415818
Email
18000194506@qq.com
Country
China
ProdList
312
Advantage
55
Shanghai Deni Biotechnology Co., Ltd.
Tel
2969901303@qq.com; QQ:2969901303
Fax
(0)13162884212;(0)18516258016
Email
2969901303@qq.com
Country
China
ProdList
1958
Advantage
58
J & K SCIENTIFIC LTD.
Tel
400-666-7788 +86-10-82848833
Fax
86-10-82849933
Email
jkinfo@jkchemical.com;market6@jkchemical.com
Country
China
ProdList
96815
Advantage
76
PharmaBlock Sciences (Nanjing),Inc.
Tel
400 025 5188
Fax
86-025-86918232
Email
sales_china@pharmablock.com
Country
China
ProdList
6448
Advantage
55
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
+86-(0)21-61259100(Shanghai) +86-(0)755-86170099(ShenZhen) +86-(0)10-62670440(Beijing)
Fax
+86-(0)21-61259102(Shanghai) +86-(0)755-86170066(ShenZhen) +86-(0)10-88580358(Beijing)
Email
sh@meryer.com
Country
China
ProdList
40269
Advantage
62
Alfa Aesar
Tel
400-610-6006; 021-67582000
Fax
021-67582001/03/05
Email
saleschina@alfa-asia.com
Country
China
ProdList
30163
Advantage
84
TAIYUAN RHF CO.,LTD.
Tel
+86 351 7031519
Fax
+86 351 7031519
Email
sales@RHFChem.com
Country
China
ProdList
2349
Advantage
56
TCI (Shanghai) Development Co., Ltd.
Tel
021-67121386 / 800-988-0390
Fax
021-67121385
Email
Sales-CN@TCIchemicals.com
Country
China
ProdList
24555
Advantage
81
ShangHai DEMO Chemical Co.,Ltd
Tel
400-021-7337 qq:2355568890
Fax
0086-21-50182339
Email
sales@demochem.com; export1@demochem.com
Country
China
ProdList
2585
Advantage
57
Energy Chemical
Tel
021-58432009 / 400-005-6266
Fax
021-58436166-800
Email
info@energy-chemical.com
Country
China
ProdList
44025
Advantage
61
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View Lastest Price from Isoflurane manufacturers

Jinan Shengqi pharmaceutical Co,Ltd
Product
Isoflurane 26675-46-7
Price
US $0.00/KG
Min. Order
1KG
Purity
99
Supply Ability
10MT
Release date
2019-03-21
Jinan Shengqi pharmaceutical Co,Ltd
Product
Isoflurane 26675-46-7
Price
US $167.00/kg
Min. Order
100ml
Purity
99
Supply Ability
10MT
Release date
2019-02-28
career henan chemical co
Product
Isoflurane 26675-46-7
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
100
Release date
2019-06-28

26675-46-7, IsofluraneRelated Search:


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