Description Chemical properties Uses Preparation method Hazards & Safety Information
ChemicalBook > CAS DataBase List > 2,2,2-Trifluoroethanol

2,2,2-Trifluoroethanol

Description Chemical properties Uses Preparation method Hazards & Safety Information
Product Name
2,2,2-Trifluoroethanol
CAS No.
75-89-8
Chemical Name
2,2,2-Trifluoroethanol
Synonyms
TFE;TFEA ;TFETOH;CF3CH2OH;TFE/TFEA;2,2,2-TrifL;uoroethanoL;Fluorinol 85;2,2,2-Trifluor;TRIFLUOROETHANOL
CBNumber
CB5736665
Molecular Formula
C2H3F3O
Formula Weight
100.04
MOL File
75-89-8.mol
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2,2,2-Trifluoroethanol Property

Melting point:
−44 °C(lit.)
Boiling point:
77-80 °C(lit.)
Density 
1.391 g/mL at 20 °C
vapor density 
3.5 (vs air)
vapor pressure 
70 mm Hg ( 25 °C)
refractive index 
n20/D 1.3(lit.)
Flash point:
85 °F
storage temp. 
Store below +30°C.
form 
Liquid
pka
12.4(at 25℃)
Specific Gravity
1.373
color 
Clear colorless
Odor
Alcoholic odour
PH Range
5-7 (10% aq soln)
explosive limit
8.4-28.8%(V)
Water Solubility 
Miscible with water, ethers, ketones, alcohols and chloroform.
λmax
λ: 260 nm Amax: ≤0.03
λ: 280 nm Amax: ≤0.02
Merck 
14,9682
BRN 
1733203
Stability:
Stable. Flammable - note wide explosion limits. Moisture sensitive. Incompatible with strong oxidizing agents, strong acids, sodium, potassium.
InChIKey
RHQDFWAXVIIEBN-UHFFFAOYSA-N
CAS DataBase Reference
75-89-8(CAS DataBase Reference)
NIST Chemistry Reference
Ethanol, 2,2,2-trifluoro-(75-89-8)
EPA Substance Registry System
2,2,2-Trifluoroethanol (75-89-8)
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Safety

Hazard Codes 
Xn,T,F
Risk Statements 
10-20/21/22-37/38-41-62-38-36/37/38
Safety Statements 
26-36-39-45-36/37/39-16
RIDADR 
UN 1986 3/PG 3
WGK Germany 
1
RTECS 
KM5250000
Autoignition Temperature
~896 °F
Hazard Note 
Flammable/Toxic
TSCA 
Yes
HazardClass 
3
PackingGroup 
III
HS Code 
29055910
Toxicity
LD50 orally in Rabbit: 240 mg/kg LD50 dermal Rat 1680 mg/kg
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H226Flammable liquid and vapour

H301Toxic if swalloed

H311Toxic in contact with skin

H312Harmful in contact with skin

H315Causes skin irritation

H318Causes serious eye damage

H331Toxic if inhaled

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P311Call a POISON CENTER or doctor/physician.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
8.08259
Product name
2,2,2-Trifluoroethanol
Purity
for synthesis
Packaging
100 mL
Price
$45.79
Updated
2021/03/22
Sigma-Aldrich
Product number
91683
Product name
2,2,2-Trifluoroethanol
Purity
analytical standard, for NMR spectroscopy
Packaging
25ml
Price
$105
Updated
2021/03/22
Sigma-Aldrich
Product number
8.08259
Product name
2,2,2-Trifluoroethanol
Purity
for synthesis
Packaging
250 mL
Price
$106.37
Updated
2021/03/22
Sigma-Aldrich
Product number
96924
Product name
2,2,2-Trifluoroethanol
Purity
BioUltra, for molecular biology, ≥99.0% (GC)
Packaging
50 mL
Price
$172
Updated
2021/03/22
Sigma-Aldrich
Product number
8.08259
Product name
2,2,2-Trifluoroethanol
Purity
for synthesis
Packaging
1 L
Price
$265.47
Updated
2021/03/22
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2,2,2-Trifluoroethanol Chemical Properties,Usage,Production

Description

2,2,2-trifluoroethanol or trifluoroethanol is called TFEA or TEF, it is important intermediate of the fluorine-containing aliphatic, it is colorless, it is miscible liquids with water, it has similar odor with ethanol. Due to the strong electron-withdrawing effect of trifluoromethyl, acid of trifluoromethyl is stronger than ethanol, it can generate hydrogen-bonded stable complex (such as: tetrahydrofuran, pyridine) with heterocyclic compound. Due to this unique physical and chemical properties and special molecular structure, it has different performance with other alcohols, it can participate in a variety of organic reactions, it can be oxidized to acetaldehyde trifluoromethyl or trifluoroacetic acid, it can also provide trifluoromethyl, it can participate in the Still-Gennari improvements of Horner-Wadsworth-Emmons reaction. It has wide range of uses in medicine, pesticides, dyes, energy, and other aspects of organic synthesis.
The main use of trifluoroethanol is as anesthetic, at the earliest, fluorine acetylene ether which synthesized by trifluoroethanol and acetylene takes place of bigger side effects of bromine-fluoro alkanes as anesthetic, and then trichloroethanol is used as raw material to develop non-flammable, low toxicity isoflurane alkanes and high performance of the new anesthetic of chlorofluoroalkane. Trifluoroethanol can be introduced into drug structure as trifluoromethyl of functional group, it can generate significant physiological activity, increase fat-soluble of molecules, improve efficacy or reduce side effects of the organism, its synthetic drugs have central nervous system stimulants fluticasone Seoul, substituted pyridines stomach cytoplasmic proton pump inhibitor Lansoprazole and Pariprazole, antiarrhythmic drugs flecainide with amines and analgesic drugs benzodiazepines and dysuria treatment KMD-3212 and so on.

Chemical properties

Boiling point is 73.6℃, melting point is-43.5℃, refractive index is 1.2940, density (25 ℃) is 1.383g/cm3, enthalpy of evaporation is 37.8kJ/mol.

Uses

(1) It can be used as import agent of trifluoroethyl and trifluoroacetic ethoxycarbonyl agent, synthetic narcotics fluoride ether (Fluroxene), isoflurane (Isoflurane) and to chlorine halothane (Desflurane), central nervous system stimulants fluticasone Seoul (Flowotyl), proton pump inhibitor lansoprazole (Lansoprazol, pp inhibitors), anti-arrhythmic drugs flecainide with amine (Flecamide), analgesics, benzodiazepines (Quazepam), difficulty urinating therapeutic drug KMD-3213, herbicide trifluoromethyl thiomethyl (Triflusulfuronmethyl).
(2) It can be used for chemical reagents.
(3) It can be used as solvent, it can be used as import agent of trifluoroethyl and trifluoroacetic ethoxycarbonyl agent, it can be also used as pharmaceutical, pesticide intermediates.
(4) It can be used as solvent, it is also used as medicine, pesticide intermediates.

Preparation method

Since 1933 Swarts used trifluoroacetic anhydride as raw material, catalytic reduction method was used to get trichloroethanol, we have developed a series of synthetic methods. According to the type, the reaction can be divided into three kinds: oxidation, reduction and hydrolysis. According to raw material, it can be divided trifluoroacetic acid method, trifluoroacetyl chloride method, trifluoroacetic anhydride method, trifluoroacetate law, trifluoroacetic acetaldehyde, polyvinylidene fluoride method, trifluoroethane (HFC-143a) method and trifluoro chloroethane (HCFC-133a) method.

Hazards & Safety Information

Category: Flammable liquid
Toxicity grading: highly toxic
Acute oral toxicity-rat LD50: 240 mg/kg; Oral-Mouse LD50: 366 mg/kg
Irritation data: Skin-Rabbit 0.75 mg/24 hours and severe; Eyes-rabbit 20 mg/24 hr mild
Flammability hazard characteristics: When meets fire, heat, oxidants, it is flammable; it can burn and generate toxic fluoride fumes.
Storage characteristics: Treasury ventilation low-temperature drying; it should be stored separately with oxidants.
Extinguishing agent: Dry powder, dry sand, carbon dioxide, foam, 1211 fire extinguishing agent.

Chemical Properties

Colorless liquid

Uses

In synthesis of medical anaesthetics, pharmaceuticals, and agrochemicals; in polymerizations. Protein denaturant; stabilizes peptide structures. Cleaning solvent; eluent in HPLC separations; working fluid in Rankine heat cycle systems. Environmentally friendly alternative to CFCs.

Safety Profile

Poison by ingestion, intravenous, and intraperitoneal routes. Moderately toxic by inhalation and skin contact. Experimental reproductive effects. A severe skin and eye irritant. When heated to decomposition it emits toxic fumes of F-.

Purification Methods

Dry it with CaSO4 and a little NaHCO3 (to remove traces of acid) and distil it. Highly TOXIC vapour. [Beilstein 1 IV 1370.]

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2,2,2-Trifluoroethanol Suppliers

West fluorine technology co., ltd
Tel
Email
325912682@qq.com
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China
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Ji'nan Langhua Chemical Co. Ltd.
Tel
0531-85906691
Fax
+86-0531-85906692
Email
325912680@qq.com
Country
China
ProdList
100
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50
Meryer (Shanghai) Chemical Technology Co., Ltd.
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21-61259100-
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86-21-61259102
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sh@meryer.com
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China
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40264
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Jinan Type Chemical Co., Ltd.
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0531-88062576
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QQ:395595425
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sales@typechem.com
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China
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ZHEJIANG ZETIAN FINE CHEMICALS CO.,LTD
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0571-87322520-
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QQ:3007632051
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sales@zetchem.com
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Jinan Guochen Taifu Chemical Co., Ltd
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0531-88162029- ; ;
Fax
0531-88162019
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guochentaifu@126.com;guochentaifu@126.com;guochentaifu@126.com
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SHANG FLUORO
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qinba_1@163.com
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China
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J & K SCIENTIFIC LTD.
Tel
010-82848833- ;010-82848833-
Fax
86-10-82849933
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jkinfo@jkchemical.com;market6@jkchemical.com
Country
China
ProdList
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Alfa Aesar
Tel
400-610-6006; 021-67582000
Fax
021-67582001/03/05
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saleschina@alfa-asia.com
Country
China
ProdList
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TCI (Shanghai) Development Co., Ltd.
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021-67121386 / 800-988-0390
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021-67121385
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Sales-CN@TCIchemicals.com
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China
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View Lastest Price from 2,2,2-Trifluoroethanol manufacturers

Zhuozhou Wenxi import and Export Co., Ltd
Product
2,2,2-Trifluoroethanol 75-89-8
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-10
Zhuozhou Wenxi import and Export Co., Ltd
Product
2,2,2-Trifluoroethanol 75-89-8
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-09
Longyan Tianhua Biological Technology Co., Ltd
Product
2,2,2-Trifluoroethanol 75-89-8
Price
US $30.00/KG
Min. Order
1KG
Purity
99
Supply Ability
1000KG
Release date
2020-11-17

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