2,2-Difluoroethanol
- Product Name
- 2,2-Difluoroethanol
- CAS No.
- 359-13-7
- Chemical Name
- 2,2-Difluoroethanol
- Synonyms
- 2,2-difluoroethan-1-ol;CHF2CH2OH;Ethanol, 2,2-difluoro-;DK755;AKOS B019710;Difluoroalcohol;ART-CHEM-BB B019710;2,3-Difluoroethanol;2,2-DIFLUOROETHANOL;2,2-Difluoroalcohol
- CBNumber
- CB8211291
- Molecular Formula
- C2H4F2O
- Formula Weight
- 82.05
- MOL File
- 359-13-7.mol
2,2-Difluoroethanol Property
- Melting point:
- -28°C
- Boiling point:
- 95 °C
- Density
- 1.296
- refractive index
- 1.338
- Flash point:
- 3°C
- storage temp.
- Sealed in dry,Store in freezer, under -20°C
- solubility
- soluble in chloroform, ethanol.
- form
- clear liquid
- pka
- 13.00±0.10(Predicted)
- color
- Colorless to Almost colorless
- Specific Gravity
- 1.296
- BRN
- 1731617
- CAS DataBase Reference
- 359-13-7(CAS DataBase Reference)
- NIST Chemistry Reference
- Difluoroethanol(359-13-7)
- EPA Substance Registry System
- 2,2-Difluoroethanol (359-13-7)
Safety
- Hazard Codes
- F,T
- Risk Statements
- 11-20/21/22-36/37/38
- Safety Statements
- 16-36/37/39-45-60-37-33-26-7
- RIDADR
- 1987
- Hazard Note
- Flammable
- HazardClass
- 3
- PackingGroup
- II
- HS Code
- 29055900
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H225Highly Flammable liquid and vapour
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P233Keep container tightly closed.
P240Ground/bond container and receiving equipment.
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P403+P235Store in a well-ventilated place. Keep cool.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- D4128
- Product name
- 2,2-Difluoroethanol
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $20
- Updated
- 2025/07/31
- Product number
- D4128
- Product name
- 2,2-Difluoroethanol
- Purity
- >98.0%(GC)
- Packaging
- 25g
- Price
- $64
- Updated
- 2025/07/31
- Product number
- D445580
- Product name
- 2,2-Difluoroethanol
- Packaging
- 25g
- Price
- $150
- Updated
- 2021/12/16
- Product number
- FD13236
- Product name
- 2,2-Difluoroethanol
- Packaging
- 25g
- Price
- $150
- Updated
- 2021/12/16
- Product number
- 005270
- Product name
- 2,2-Difluoroethanol
- Purity
- 95%
- Packaging
- 100g
- Price
- $168
- Updated
- 2021/12/16
2,2-Difluoroethanol Chemical Properties,Usage,Production
Chemical Properties
Colorless Liquid
Uses
2,2-Difluoroethanol is used as a chemical intermediates. It has wide applications in medicine and fluoropolymers.
Synthesis Reference(s)
Journal of Medicinal Chemistry, 23, p. 985, 1980 DOI: 10.1021/jm00183a005
Synthesis
1550-44-3
359-13-7
Example 13: Synthesis of 2,2-difluoroethanol from ethyl 2,2-difluoroacetate (Step b2) In a 0.5 L glass reactor equipped with a mechanical stirrer, reflux condenser and temperature probe, 164 g of ethyl 2,2-difluoroacetate (GC purity 95%), 106 g of methanol, and 3 g of solid NaOH were added. the reaction was carried out at 65 °C for 2 h until the conversion was complete. The 2,2-difluoroethanol was isolated by distillation to give 96.3% GC purity and 87% isolated yield.
References
[1] Patent: CN107986944, 2018, A. Location in patent: Paragraph 0020; 0023; 0026; 0029; 0032
[2] Patent: WO2009/40367, 2009, A1. Location in patent: Page/Page column 12
[3] Patent: US2014/243561, 2014, A1. Location in patent: Paragraph 0040; 0041; 0042
[4] Patent: WO2009/40367, 2009, A1. Location in patent: Page/Page column 10
[5] Patent: CN108178723, 2018, A. Location in patent: Paragraph 0015; 0016; 0018; 0020
2,2-Difluoroethanol Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2,2-Difluoroethanol manufacturers
- Product
- 2,2-Difluoroethanol 359-13-7
- Price
- US $10.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 10 mt
- Release date
- 2024-12-05
- Product
- 2,2-Difluoroethanol 359-13-7
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 99.99%
- Supply Ability
- 20 tons
- Release date
- 2025-04-14
- Product
- 2,2-Difluoroethanol 359-13-7
- Price
- US $10.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 20 ton
- Release date
- 2024-12-23