ChemicalBook > CAS DataBase List > 2,2-Difluoroethanol

2,2-Difluoroethanol

Product Name
2,2-Difluoroethanol
CAS No.
359-13-7
Chemical Name
2,2-Difluoroethanol
Synonyms
2,2-difluoroethan-1-ol;CHF2CH2OH;Ethanol, 2,2-difluoro-;DK755;AKOS B019710;Difluoroalcohol;ART-CHEM-BB B019710;2,3-Difluoroethanol;2,2-DIFLUOROETHANOL;2,2-Difluoroalcohol
CBNumber
CB8211291
Molecular Formula
C2H4F2O
Formula Weight
82.05
MOL File
359-13-7.mol
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2,2-Difluoroethanol Property

Melting point:
-28°C
Boiling point:
95 °C
Density 
1.296
refractive index 
1.338
Flash point:
3°C
storage temp. 
Sealed in dry,Store in freezer, under -20°C
solubility 
soluble in chloroform, ethanol.
form 
clear liquid
pka
13.00±0.10(Predicted)
color 
Colorless to Almost colorless
Specific Gravity
1.296
BRN 
1731617
CAS DataBase Reference
359-13-7(CAS DataBase Reference)
NIST Chemistry Reference
Difluoroethanol(359-13-7)
EPA Substance Registry System
2,2-Difluoroethanol (359-13-7)
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Safety

Hazard Codes 
F,T
Risk Statements 
11-20/21/22-36/37/38
Safety Statements 
16-36/37/39-45-60-37-33-26-7
RIDADR 
1987
Hazard Note 
Flammable
HazardClass 
3
PackingGroup 
II
HS Code 
29055900
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H225Highly Flammable liquid and vapour

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P233Keep container tightly closed.

P240Ground/bond container and receiving equipment.

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P403+P235Store in a well-ventilated place. Keep cool.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TCI Chemical
Product number
D4128
Product name
2,2-Difluoroethanol
Purity
>98.0%(GC)
Packaging
5g
Price
$20
Updated
2025/07/31
TCI Chemical
Product number
D4128
Product name
2,2-Difluoroethanol
Purity
>98.0%(GC)
Packaging
25g
Price
$64
Updated
2025/07/31
TRC
Product number
D445580
Product name
2,2-Difluoroethanol
Packaging
25g
Price
$150
Updated
2021/12/16
Oakwood
Product number
001565
Product name
2,2-Difluoroethanol
Packaging
1g
Price
$10
Updated
2021/12/16
Oakwood
Product number
001565
Product name
2,2-Difluoroethanol
Packaging
5g
Price
$13
Updated
2021/12/16
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2,2-Difluoroethanol Chemical Properties,Usage,Production

Chemical Properties

Colorless Liquid

Uses

2,2-Difluoroethanol is used as a chemical intermediates. It has wide applications in medicine and fluoropolymers.

Synthesis Reference(s)

Journal of Medicinal Chemistry, 23, p. 985, 1980 DOI: 10.1021/jm00183a005

Synthesis

1550-44-3

359-13-7

Example 13: Synthesis of 2,2-difluoroethanol from ethyl 2,2-difluoroacetate (Step b2) In a 0.5 L glass reactor equipped with a mechanical stirrer, reflux condenser and temperature probe, 164 g of ethyl 2,2-difluoroacetate (GC purity 95%), 106 g of methanol, and 3 g of solid NaOH were added. the reaction was carried out at 65 °C for 2 h until the conversion was complete. The 2,2-difluoroethanol was isolated by distillation to give 96.3% GC purity and 87% isolated yield.

References

[1] Patent: CN107986944, 2018, A. Location in patent: Paragraph 0020; 0023; 0026; 0029; 0032
[2] Patent: WO2009/40367, 2009, A1. Location in patent: Page/Page column 12
[3] Patent: US2014/243561, 2014, A1. Location in patent: Paragraph 0040; 0041; 0042
[4] Patent: WO2009/40367, 2009, A1. Location in patent: Page/Page column 10
[5] Patent: CN108178723, 2018, A. Location in patent: Paragraph 0015; 0016; 0018; 0020

2,2-Difluoroethanol Preparation Products And Raw materials

Raw materials

Preparation Products

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2,2-Difluoroethanol Suppliers

Americas 1 Belgium 1 CHINA 316 Europe 2 France 2 Germany 7 India 4 Japan 4 Russia 3 South Korea 1 The Netherlands 1 United Kingdom 15 United States 32 Global 389
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View Lastest Price from 2,2-Difluoroethanol manufacturers

Hebei Chuanghai Biotechnology Co., Ltd
Product
2,2-Difluoroethanol 359-13-7
Price
US $10.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
10 mt
Release date
2024-12-05
Chongqing Soarwin Technology Co., Ltd
Product
2,2-Difluoroethanol 359-13-7
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
99.99%
Supply Ability
20 tons
Release date
2025-04-14
Hebei Zhuanglai Chemical Trading Co Ltd
Product
2,2-Difluoroethanol 359-13-7
Price
US $10.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
20 ton
Release date
2024-12-23

359-13-7, 2,2-DifluoroethanolRelated Search:

CHLORODIFLUOROACETIC ANHYDRIDE Trifluoroacetic anhydride Ethyl trifluoroacetate Methyl pentafluoropropionate TRIMETHYLSILYL TRIFLUOROACETATE TRIFLUOROACETALDEHYDE ETHYL HEMIACETAL METHYL CHLORODIFLUOROACETATE Heptafluorobutyric anhydride THALLIUM(III) TRIFLUOROACETATE (R)-(-)-2,2,2-TRIFLUORO-1-(9-ANTHRYL)ETHANOL 2,2,2-TRIFLUOROETHYL TRIFLUOROACETATE METHYL HEPTAFLUOROBUTYRATE 2,2,2-TRIFLUOROETHYL P-TOLUENESULFONATE 2-METHOXY-2-PHENYL-3,3,3-TRIFLUOROPROPIONITRILE ETHYL HEPTAFLUOROBUTYRATE Methyl trifluoroacetate Perfluoropropionic anhydride 2,2,2-Trifluoroethyl acrylate

  • CHF2CH2OH
  • Ethanol, 2,2-difluoro-
  • 2,2-Difluoroethanol,95%
  • 2,2-Difluoroethanol 97%
  • 2,2-Difluoroethanol97%
  • 2,3-Difluoroethanol
  • 2,2-difluoroethan-1-ol
  • 1,1-Difluoro-2-hydroxyethane
  • 2,2-Difluoroethan-1-ol 97%
  • ART-CHEM-BB B019710
  • AKOS B019710
  • 2,2-DIFLUOROETHANOL
  • 2,2-Difluoroethanol&gt
  • Ethanol, 2,2-difluoro- (6CI,7CI,8CI,9CI)
  • DK755
  • Difluoroalcohol
  • 2,2-Difluoroalcohol
  • 359-13-7
  • 359-17-3
  • HCF2CH2OH
  • C2H4F2O
  • C2H4OF2
  • Four-membered heterocyclic compound
  • bc0001