ChemicalBook > CAS DataBase List > N-[(1R)-1-[[[[4-[[(Aminocarbonyl)amino]methyl]phenyl]methyl]amino]carbonyl]-4-[(aminoiminomethyl)amino]butyl]-α-phenyl-benzeneacetamideditrifluoroacetate

N-[(1R)-1-[[[[4-[[(Aminocarbonyl)amino]methyl]phenyl]methyl]amino]carbonyl]-4-[(aminoiminomethyl)amino]butyl]-α-phenyl-benzeneacetamideditrifluoroacetate

Product Name
N-[(1R)-1-[[[[4-[[(Aminocarbonyl)amino]methyl]phenyl]methyl]amino]carbonyl]-4-[(aminoiminomethyl)amino]butyl]-α-phenyl-benzeneacetamideditrifluoroacetate
CAS No.
191868-14-1
Chemical Name
N-[(1R)-1-[[[[4-[[(Aminocarbonyl)amino]methyl]phenyl]methyl]amino]carbonyl]-4-[(aminoiminomethyl)amino]butyl]-α-phenyl-benzeneacetamideditrifluoroacetate
Synonyms
BIB03304;BIBO 3304;BIBO3304 TFA;BIBO 3304 trifluoroa;BIBO 3304 (BIBO3304);BIBO 3304 trifluoroacetate;BIBO3304 TFA, 10 mM in DMSO;BIBO-3304 (trifluoroacetate salt);(R)-2-(2,2-Diphenylacetamido)-5-guanidino-N-(4-(ureidomethyl)benzyl)pentanamide 2,2,2-trifluoroacetate;N-[(1R)-1-[[[[4-[[(Aminocarbonyl)amino]methyl]phenyl]methyl]amino]carbonyl]-4-[(aminoiminomethyl)amino]butyl]-α-phenyl-benzeneacetamideditrifluoroacetate
CBNumber
CB32518838
Molecular Formula
C31H36F3N7O5
Formula Weight
643.67
MOL File
191868-14-1.mol
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N-[(1R)-1-[[[[4-[[(Aminocarbonyl)amino]methyl]phenyl]methyl]amino]carbonyl]-4-[(aminoiminomethyl)amino]butyl]-α-phenyl-benzeneacetamideditrifluoroacetate Property

storage temp. 
Store at +4°C
solubility 
<75.77mg/ml in DMSO; <75.77mg/ml in ethanol
form 
solid
color 
White
InChIKey
FBMCYYWIBYEOST-NETKZVBLNA-N
SMILES
C(F)(F)(F)C(=O)O.C(C1C=CC=CC=1)(C1C=CC=CC=1)C(=O)N[C@H](CCCNC(N)=N)C(=O)NCC1C=CC(CNC(=O)N)=CC=1 |&1:23,r|
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Tocris
Product number
2412
Product name
BIBO3304trifluoroacetate
Purity
≥98%(HPLC)
Packaging
10
Price
$338
Updated
2021/12/16
Tocris
Product number
2412
Product name
BIBO3304trifluoroacetate
Purity
≥98%(HPLC)
Packaging
50
Price
$1426
Updated
2021/12/16
TRC
Product number
B377005
Product name
BIBO3304Trifluoroacetate
Packaging
1mg
Price
$160
Updated
2021/12/16
Usbiological
Product number
254748
Product name
BIBO 3304 trifluoroacetate
Packaging
10mg
Price
$616
Updated
2021/12/16
ChemScene
Product number
CS-0029393
Product name
BIBO3304(TFA)
Purity
99.95%
Packaging
25mg
Price
$850
Updated
2021/12/16
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N-[(1R)-1-[[[[4-[[(Aminocarbonyl)amino]methyl]phenyl]methyl]amino]carbonyl]-4-[(aminoiminomethyl)amino]butyl]-α-phenyl-benzeneacetamideditrifluoroacetate Chemical Properties,Usage,Production

Uses

BIBO 3304 Trifluoroacetate is a high affinity NPY1-R antagonist, that inhibits NPY- and fasting-induced feeding in vivo following central administration. blockade of Y1 receptors may offer a novel anabolic treatment option for improving bone mass.

in vivo

BIBO3304 (30 μg; bilateral paraventricular nucleus injection) attenuates the hyperphagia following fasting[1].
BIBO3304 (15-60 μg) dose-dependently inhibits the feeding reponse mediated by 1 μg NPY[1].
BIBO3304 (0.5?μM; p.o.) significantly increases serum insulin levels[2].

Animal Model:Adult male Chbb:Thom rats weighing between 300 and 340 g[1]
Dosage:30 μg
Administration:bilateral paraventricular nucleus injection
Result:Attenuated the hyperphagia following fasting, especially during the first 2 h of refeeding.
Animal Model:7-week-old C57BL/6JAusb mice[2]
Dosage:0.5?μM
Administration:p.o.
Result:Significantly increased serum insulin levels.

IC 50

NPY Y1 receptor

N-[(1R)-1-[[[[4-[[(Aminocarbonyl)amino]methyl]phenyl]methyl]amino]carbonyl]-4-[(aminoiminomethyl)amino]butyl]-α-phenyl-benzeneacetamideditrifluoroacetate Preparation Products And Raw materials

Raw materials

Preparation Products

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N-[(1R)-1-[[[[4-[[(Aminocarbonyl)amino]methyl]phenyl]methyl]amino]carbonyl]-4-[(aminoiminomethyl)amino]butyl]-α-phenyl-benzeneacetamideditrifluoroacetate Suppliers

China 64 United Kingdom 1 United States 9 Global 74
Hangzhou Baige Pharmaceutical Technology Co. , Ltd.
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0571-85350119 15888826472
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15888826472@163.com
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China
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3B Pharmachem (Wuhan) International Co.,Ltd.
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821-50328103-801 18930552037
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86-21-50328109
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3bsc@sina.com
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China
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EMMX Biotechnology LLC
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888-539-0666
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888-539-0666
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info@emmx.com
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United States
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Shanghai EFE Biological Technology Co., Ltd.
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021-65675885 18964387627
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021-65675885
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Shanghai YuanYe Biotechnology Co., Ltd.
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021-61312847; 18021002903
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3008007409@qq.com
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ShangHai Biochempartner Co.,Ltd
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177-54423994 17754423994
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Shanghai Rechem science Co., Ltd.
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021-31433387 15618786686
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sales@rechemscience.com
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Shanghai Chaolan Chemical Technology Center
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021-QQ：65489617 15618227136
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21-5161 9052
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Sales@ATKchemical.com
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China
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Hangzhou Peptidego Biotech Co.,Ltd.
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0571-87213919
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Eric@peptidego.com
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China
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TargetMol Chemicals Inc.
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+1-781-999-5354; +17819995354
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marketing@targetmol.com
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United States
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191868-14-1, N-[(1R)-1-[[[[4-[[(Aminocarbonyl)amino]methyl]phenyl]methyl]amino]carbonyl]-4-[(aminoiminomethyl)amino]butyl]-α-phenyl-benzeneacetamideditrifluoroacetateRelated Search:


  • BIBO 3304 trifluoroacetate
  • BIBO 3304
  • BIBO 3304 (BIBO3304)
  • BIBO3304 TFA
  • BIBO 3304 trifluoroa
  • (R)-2-(2,2-Diphenylacetamido)-5-guanidino-N-(4-(ureidomethyl)benzyl)pentanamide 2,2,2-trifluoroacetate
  • N-[(1R)-1-[[[[4-[[(Aminocarbonyl)amino]methyl]phenyl]methyl]amino]carbonyl]-4-[(aminoiminomethyl)amino]butyl]-α-phenyl-benzeneacetamideditrifluoroacetate
  • Inhibitor,Neuropeptide Y Receptor,subtype,BIBO3304,inhibit,insulin,NPY receptor,serum,hyperphagia,BIBO-3304,BIBO-3304 TFA,oral,BIBO3304 TFA,refeeding,BIBO 3304
  • BIBO-3304 (trifluoroacetate salt)
  • BIB03304
  • BIBO3304 TFA, 10 mM in DMSO
  • 191868-14-1
  • C29H35N7O32CF3CO2H