2-(1,3-Dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-[4-(1-methylpropyl)phenyl]acetamide

Product Name: 2-(1,3-Dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-[4-(1-methylpropyl)phenyl]acetamide
CAS No.: 332117-28-9
Chemical Name: 2-(1,3-Dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-[4-(1-methylpropyl)phenyl]acetamide
Synonyms: CS-1651;TCS 5861528;CheMbridge 5861528;Chembridge-5861528, 10 mM in DMSO;TCS 5861528;TCS-5861528;TCS5861528;CHEMBRIDGE-5861528;TCS-5861528;TCS5861528;N-(4-(sec-Butyl)phenyl)-2-(1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)acetamide;N-[4-(butan-2-yl)phenyl]-2-(1,3-dimethyl-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-7-yl)acetamide;7H-Purine-7-acetamide, 1,2,3,6-tetrahydro-1,3-dimethyl-N-[4-(1-methylpropyl)phenyl]-2,6-dioxo-;2-(1,3-Dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-[4-(1-methylpropyl)phenyl]acetamide
CBNumber: CB32518883
Molecular Formula: C19H23N5O3
Formula Weight: 369.42
MOL File: 332117-28-9.mol

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2-(1,3-Dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-[4-(1-methylpropyl)phenyl]acetamide Property

Density: 1.30±0.1 g/cm3(Predicted)
storage temp.: Store at RT
solubility: DMSO : 74 mg/mL (200.31 mM; Need ultrasonic and warming)
form: Powder
pka: 13.75±0.70(Predicted)
color: White to off-white

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 18380
Product name: TCS 5861528
Purity: ≥98%
Packaging: 5mg
Price: $81
Updated: 2024/03/01

Cayman Chemical

Product number: 18380
Product name: TCS 5861528
Purity: ≥98%
Packaging: 10mg
Price: $158
Updated: 2024/03/01

Cayman Chemical

Product number: 18380
Product name: TCS 5861528
Purity: ≥98%
Packaging: 25mg
Price: $356
Updated: 2024/03/01

Cayman Chemical

Product number: 18380
Product name: TCS 5861528
Purity: ≥98%
Packaging: 50mg
Price: $632
Updated: 2024/03/01

Tocris

Product number: 3938
Product name: TCS5861528
Purity: ≥98%(HPLC)
Packaging: 10
Price: $164
Updated: 2021/12/16

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2-(1,3-Dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-[4-(1-methylpropyl)phenyl]acetamide Chemical Properties,Usage,Production

Uses

TCS 5861528 is a TRPA1 channel antagonist, which may prevent development of diabetic hypersensitivity.

in vivo

Chembridge-5861528 (TCS 5861528) (30 mg/kg; i.p.; twice daily for a week) significantly attenuates development of mechanical hypersensitivity in Streptozocin (HY-13753)-induced diabetes mellitus rat model^[1].
Chembridge-5861528 (3 and 10 μg/rat; i.t.; once) attenuates Capsaicin.html" class="link-product" target="_blank">Capsaicin (HY-10448)-induced blood flow increase in a dose-related fashion^[2].

Animal Model:	Male Hannover-Wistar rats, Streptozocin-induced diabetes mellitus model^[1]
Dosage:	30 mg/kg
Administration:	Intraperitoneal injection, twice daily for a week
Result:	Significantly attenuated development of mechanical hypersensitivity as revealed by the paw pressure test (F^1,80= 31.4, P < 0.0001).

Animal Model:	Male Hannover–Wistar rats (220-260 g), Capsaicin-induced neurogenic inflammation model^[2]
Dosage:	0, 3, and 10 μg/rat
Administration:	Intrathecal injection, 20 min before Capsaicin injection
Result:	Significantly decreased the blood flow at 10 μg.

IC 50

TRPA1: 14.3 μM (IC₅₀, allyl isothiocyanate-evoked TRPA1 response); TRPA1: 18.7 μM (IC₅₀, 4-HNE-evoked TRPA1 response)

storage

Store at RT

2-(1,3-Dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-[4-(1-methylpropyl)phenyl]acetamide Preparation Products And Raw materials

Raw materials

Preparation Products

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2-(1,3-Dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-[4-(1-methylpropyl)phenyl]acetamide Suppliers

China 64 United Kingdom 2 United States 9 Global 75

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332117-28-9, 2-(1,3-Dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-[4-(1-methylpropyl)phenyl]acetamideRelated Search:

6-Chloro-N4-[3,5-difluoro-4-[(3-methyl-1H-pyrrolo[2,3-b]pyridin-4-yl)oxy]phenyl]-2,4-pyrimidinediamine

2-(1,3-Dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-[4-(1-methylpropyl)phenyl]acetamide

TCS 5861528

CheMbridge 5861528

TCS 5861528;TCS-5861528;TCS5861528

CS-1651

CHEMBRIDGE-5861528;TCS-5861528;TCS5861528

7H-Purine-7-acetamide, 1,2,3,6-tetrahydro-1,3-dimethyl-N-[4-(1-methylpropyl)phenyl]-2,6-dioxo-

N-(4-(sec-Butyl)phenyl)-2-(1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)acetamide

Chembridge-5861528,Chembridge 5861528,diabetes mellitus,Transient receptor potential channels,Inhibitor,inhibit,TCS-5861528,antihypersensitivity,neurogenic inflammation,TRP Channel,TCS5861528,Chembridge5861528

N-[4-(butan-2-yl)phenyl]-2-(1,3-dimethyl-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-7-yl)acetamide

Chembridge-5861528, 10 mM in DMSO

332117-28-9

Inhibitors