ChemicalBook > CAS DataBase List > 4-[1-Cyclohexyl-4-(4-fluorophenyl)-1H-imidazol-5-yl]-2-pyrimidinaminedihydrochloride

4-[1-Cyclohexyl-4-(4-fluorophenyl)-1H-imidazol-5-yl]-2-pyrimidinaminedihydrochloride

Product Name: 4-[1-Cyclohexyl-4-(4-fluorophenyl)-1H-imidazol-5-yl]-2-pyrimidinaminedihydrochloride
CAS No.: 950912-80-8
Chemical Name: 4-[1-Cyclohexyl-4-(4-fluorophenyl)-1H-imidazol-5-yl]-2-pyrimidinaminedihydrochloride
Synonyms: CS-318;PF 67046;PF 670462;PF-670462 HCL;PF-670462 2HCl;PF 670462, >=98%;PF670462/ PF-670462;PF670462 dihydrochloride;PF-670462, 10 mM in DMSO;PF-670462 (hydrochloride)
CBNumber: CB32518984
Molecular Formula: C19H20FN5.2HCl
Formula Weight: 410
MOL File: 950912-80-8.mol

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4-[1-Cyclohexyl-4-(4-fluorophenyl)-1H-imidazol-5-yl]-2-pyrimidinaminedihydrochloride Property

Melting point:: >178°C (dec.)
storage temp.: 2-8°C
solubility: H2O: soluble2mg/mL, clear (warmed)
form: powder
color: white to beige
Water Solubility: H2O: 2mg/mL, clear (warmed)
InChI: InChI=1S/C19H20FN5.2ClH/c20-14-8-6-13(7-9-14)17-18(16-10-11-22-19(21)24-16)25(12-23-17)15-4-2-1-3-5-15;;/h6-12,15H,1-5H2,(H2,21,22,24);2*1H
InChIKey: PSNKGVAXBSAHCH-UHFFFAOYSA-N
SMILES: C1(N)=NC=CC(C2N(C3CCCCC3)C=NC=2C2=CC=C(F)C=C2)=N1.[H]Cl.[H]Cl

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Safety

WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML0795
Product name: PF-670462
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $136
Updated: 2025/07/31

Cayman Chemical

Product number: 14588
Product name: PF-670462 (hydrochloride)
Purity: ≥99%
Packaging: 10mg
Price: $166
Updated: 2024/03/01

Cayman Chemical

Product number: 14588
Product name: PF-670462 (hydrochloride)
Purity: ≥99%
Packaging: 50mg
Price: $576
Updated: 2024/03/01

Sigma-Aldrich

Product number: SML0795
Product name: PF-670462
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $552
Updated: 2025/07/31

Tocris

Product number: 3316
Product name: PF670462
Purity: ≥99%(HPLC)
Packaging: 50
Price: $980
Updated: 2021/12/16

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4-[1-Cyclohexyl-4-(4-fluorophenyl)-1H-imidazol-5-yl]-2-pyrimidinaminedihydrochloride Chemical Properties,Usage,Production

Description

The casein kinase 1 (CK1) family of kinases regulate diverse processes, particularly related to circadian rhythms and sensitivity to amphetamines. PF-670462 is a potent inhibitor of the CK1 isoforms CK1ε and CK1δ (IC₅₀ = 7.7 and 14 nM, respectively). It less effectively inhibits a wide variety of related or common kinases. Through its effects on CK1, PF-670462 disrupts circadian rhythms in cells and animals. It also blocks the locomotor response to amphetamines in mice.

Uses

PF 670462 is a potent and selective casein kinase 1ε (CK1ε) and CK1δ inhibitor. PF 670462 has been shown to inhibit PER protein nuclear translocation causing phase shifts in circadian rhythms. PF 670462 attenuates methamphetamine-stimulated locomotion in vivo.

Definition

ChEBI: A hydrochloride salt resulting from the formal reaction of 3-[(3-chlorophenoxy)methyl]-1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine with 2 mol eq. of hydrogen chloride. It is a selectiv inhibitor of the delta- and epsilon-isoforms of casein kinase 1 (CK1delta and CK1epsilon).

Biochem/physiol Actions

PF-670462 is also termed as 4-[1-cyclohexyl-4-(4-fluorophenyl)-1H-imidazol-5-yl]-2-pyrimidinamine dihydrochloride). It participates in ceramide transfer between Golgi and ER (endoplasmic reticulum) compartments. PF-670462 affects actin filament consolidation. It also hinders the stability at the front edge of cells treated with N-formyl Met-Leu-Phe.

storage

room temperature (desiccate)

References

[1] LORI BADURA. An inhibitor of casein kinase I epsilon induces phase delays in circadian rhythms under free-running and entrained conditions.[J]. ACS Applied Electronic Materials, 2007: 730-738. DOI: 10.1124/jpet.107.122846
[2] SIMA SMADJA STORZ. Casein kinase 1δ activity: a key element in the zebrafish circadian timing system.[J]. PLoS ONE, 2013: e54189. DOI: 10.1371/journal.pone.0054189
[3] CAMRON D BRYANT. A role for casein kinase 1 epsilon in the locomotor stimulant response to methamphetamine.[J]. Psychopharmacology, 2009, 203 4: 703-711. DOI: 10.1007/s00213-008-1417-z

4-[1-Cyclohexyl-4-(4-fluorophenyl)-1H-imidazol-5-yl]-2-pyrimidinaminedihydrochloride Preparation Products And Raw materials

Raw materials

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View Lastest Price from 4-[1-Cyclohexyl-4-(4-fluorophenyl)-1H-imidazol-5-yl]-2-pyrimidinaminedihydrochloride manufacturers

Career Henan Chemical Co

Product: 4-[1-Cyclohexyl-4-(4-fluorophenyl)-1H-imidazol-5-yl]-2-pyrimidinaminedihydrochloride 950912-80-8
Price: US $1.00/KG
Min. Order: 100KG
Purity: 99.0%
Supply Ability: 1000kg
Release date: 2020-03-11

950912-80-8, 4-[1-Cyclohexyl-4-(4-fluorophenyl)-1H-imidazol-5-yl]-2-pyrimidinaminedihydrochlorideRelated Search:

2-FLUOROPHENYL CYCLOPENTYL KETONE TRIS(PENTAFLUOROPHENYL)BORANE

PF670462/ PF-670462

4-[1-Cyclohexyl-4-(4-fluorophenyl)-1H-imidazol-5-yl]-2-pyrimidinamine hydrochloride

2-PyriMidinaMine, 4-[1-cyclohexyl-4-(4-fluorophenyl)-1H-iMidazol-5-yl]-, hydrochloride (1:2)

PF 67046

4-[1-Cyclohexyl-4-(4-fluorophenyl)-1H-imidazol-5-yl]-2-pyrimidinamine hydrochloride PF670462

4-[3-Cyclohexyl-5-(4-fluoro-phenyl)-3H-imidazol-4-yl]-pyrimidin-2-ylamine dihydrochloride

PF 670462, >=98%

PF 670462

PF-670462 2HCl

PF-670462 (hydrochloride)

Casein Kinase I Inhibitor II, PF-670462

4-[1-Cyclohexyl-4-(4-fluorophenyl)-1H-imidazol-5-yl]-2-pyrimidinaminedihydrochloride

4-[3-cyclohexyl-5-(4-fluorophenyl)imidazol-4-yl]pyrimidin-2-amine:dihydrochloride

Casein Kinase I Inhibitor II, PF-670462 - CAS 950912-80-8 - Calbiochem

4-[1-cyclohexyl-4-(4-fluorophenyl)-1H-imidazol-5-yl]pyrimidin-2-amine dihydrochloride

CS-318

PF670462 dihydrochloride

PF-670462 HCL

PF 670462, casein kinase 1epsilon (CK1epsilon) and CK1delta inhibitor

PF-670462, 10 mM in DMSO

950912-80-8

C19H20FN52ClH

C19H20FN52HCl

C19H22Cl2FN5

Inhibitors

Aromatics

Heterocycles

Intermediates & Fine Chemicals

Pharmaceuticals

Protein Kinase Inhibitors and Activators