5-Hydroxy-1,3-dihydro-isoindole-2-carboxylic acid tert-butyl ester
- Product Name
- 5-Hydroxy-1,3-dihydro-isoindole-2-carboxylic acid tert-butyl ester
- CAS No.
- 226070-47-9
- Chemical Name
- 5-Hydroxy-1,3-dihydro-isoindole-2-carboxylic acid tert-butyl ester
- Synonyms
- N-Boc-5-hydroxyisoindoline;tert-Butyl 5-hydroxyisoindoline-2-carboxylate;5-Hydroxy-1,3-dihdro-isoindole-2-carboxylic acid tert-bu;tert-butyl 5-hydroxy-2,3-dihydro-1H-isoindole-2-carboxylate;5-Hydroxy-1,3-dihydro-isoindole-2-carboxylic acid tert-butyl ester;2H-Isoindole-2-carboxylic acid, 1,3-dihydro-5-hydroxy-, 1,1-dimethylethyl ester
- CBNumber
- CB32520224
- Molecular Formula
- C13H17NO3
- Formula Weight
- 235.28
- MOL File
- 226070-47-9.mol
5-Hydroxy-1,3-dihydro-isoindole-2-carboxylic acid tert-butyl ester Property
- Boiling point:
- 372.9±42.0 °C(Predicted)
- Density
- 1.205±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- pka
- 10.18±0.20(Predicted)
- Appearance
- Off-white to light yellow Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- CHM0394218
- Product name
- TERT-BUTYL-5-HYDROXYISOINDOLINE-2-CARBOXYLATE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $497.26
- Updated
- 2021/12/16
- Product number
- 154015
- Product name
- 5-Hydroxy-1,3-dihydro-isoindole-2-carboxylic acid tert-butyl ester
- Purity
- 95%
- Packaging
- 1g
- Price
- $833
- Updated
- 2021/12/16
- Product number
- 1374AB
- Product name
- tert-Butyl5-hydroxyisoindoline-2-carboxylate
- Packaging
- 10g
- Price
- $1391
- Updated
- 2021/12/16
- Product number
- CD11162750
- Product name
- tert-Butyl5-hydroxyisoindoline-2-carboxylate
- Purity
- 95%
- Packaging
- 250mg
- Price
- $262
- Updated
- 2021/12/16
- Product number
- 226070479
- Product name
- tert-Butyl5-hydroxyisoindoline-2-carboxylate
- Packaging
- 250mg
- Price
- $275.6
- Updated
- 2021/12/16
5-Hydroxy-1,3-dihydro-isoindole-2-carboxylic acid tert-butyl ester Chemical Properties,Usage,Production
Uses
tert-Butyl 5-Hydroxyisoindoline-2-carboxylate is used in preparation of resorcylate aminopyrazole compounds as Hsp90 inhibitors and uses thereof.
Synthesis
50727-06-5
24424-99-5
226070-47-9
General procedure for the synthesis of tert-butyl 5-hydroxyisoindoline-2-carboxylate by the reaction of 5-hydroxyisoindole-1,3-dione with di-tert-butyl dicarbonate: 1. Preparation of 2,3-dihydro-5-hydroxy-1H-isoindole (7): 750 mL of 1 M borane/THF solution was added dropwise to 300 mL of dry THF containing 20 mL (125 mmol) of 5-hydroxyisoindole-1,3-dione at -5 °C for 60 min. Subsequently, the reaction mixture was stirred at 22°C for 2 hours and then at 80°C for 16 hours. 2. Upon completion of the reaction, the mixture was cooled to 0 °C and 100 mL of methanol (note exothermic) and 100 mL of 2M hydrochloric acid were slowly added. The resulting mixture was stirred at 80°C for 3 hours, then cooled to 22°C and 100 mL of water was added. 3. The aqueous solution was extracted three times with dichloromethane (150 mL each time). To the aqueous solution was added 27.8 g (125 mmol) of di-tert-butyl dicarbonate and 12.6 g (125 mmol) of triethylamine, and the mixture was stirred at 22°C for 30 minutes. 4. The reaction mixture was again extracted three times with dichloromethane (100 mL each time). The organic phases were combined, dried over sodium sulfate, filtered, and the filtrate evaporated to dryness under vacuum. 5. The crude product was ground with petroleum ether to give 6.7 g (22% yield) of light beige crystals of tert-butyl 5-hydroxyisoindoline-2-carboxylate (6). 1H-NMR (500 MHz, DMSO-d6/TFA-d1, 90 °C): δ [ppm] 7.093 (m, 1H), 6.709 (m, 2H), 4.486 (m, 4H), 1.457 (s, 9H); Molecular Weight (MW) 235.3.
References
[1] Patent: US2010/311745, 2010, A1. Location in patent: Page/Page column 18
5-Hydroxy-1,3-dihydro-isoindole-2-carboxylic acid tert-butyl ester Preparation Products And Raw materials
Raw materials
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