ethyl 2-(oxetan-3-ylidene)acetate

Product Name: ethyl 2-(oxetan-3-ylidene)acetate
CAS No.: 922500-91-2
Chemical Name: ethyl 2-(oxetan-3-ylidene)acetate
Synonyms: oxetan-3-ylidene-acetic acid ethyl ester;Ethyl 3-Oxetanylideneacetate;Ethyl 2-(oxetan-3-ylidene...;Ethyl oxetan-3-ylideneacetate;ethyl 2-(oxetan-3-ylidene)acetate;Heterocyclic butane-3-methylacetate ethyl;Acetic acid, 2-(3-oxetanylidene)-, ethyl ester
CBNumber: CB32520486
Molecular Formula: C7H10O3
Formula Weight: 142.15
MOL File: 922500-91-2.mol

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ethyl 2-(oxetan-3-ylidene)acetate Property

Boiling point:: 207℃
Density: 1.228
Flash point:: 78℃
storage temp.: Sealed in dry,Store in freezer, under -20°C
form: liquid
color: Colourless to light yellow
InChI: InChI=1S/C7H10O3/c1-2-10-7(8)3-6-4-9-5-6/h3H,2,4-5H2,1H3
InChIKey: CVZGHWOZWYWLBL-UHFFFAOYSA-N
SMILES: C(OCC)(=O)/C=C1\COC\1

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Safety

Risk Statements: 36/37/38
Safety Statements: 26-36
HS Code: 29329990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

TRC

Product number: E936918
Product name: Ethyl2-(Oxetan-3-ylidene)acetate
Packaging: 500mg
Price: $130
Updated: 2021/12/16

SynQuest Laboratories

Product number: 2223-1-40
Product name: Ethyl 2-(oxetan-3-ylidene)acetate
Packaging: 5G
Price: $500
Updated: 2021/12/16

Matrix Scientific

Product number: 067034
Product name: Ethyl 2-(oxetan-3-ylidene)acetate
Purity: >95%
Packaging: 1g
Price: $814
Updated: 2021/12/16

Synthonix

Product number: E1599
Product name: Ethyl2-(oxetan-3-ylidene)acetate
Purity: 97.0%
Packaging: 5g
Price: $140
Updated: 2021/12/16

SynQuest Laboratories

Product number: 2223-1-40
Product name: Ethyl 2-(oxetan-3-ylidene)acetate
Packaging: 1g
Price: $144
Updated: 2021/12/16

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ethyl 2-(oxetan-3-ylidene)acetate Chemical Properties,Usage,Production

Uses

Ethyl 2-(Oxetan-3-ylidene)acetate is a CBL-?B inhibitors which is used in the treatment of cancer.

Synthesis

6704-31-0

1099-45-2

922500-91-2

Oxetan-3-one (500 mg, 6.938 mmol) was dissolved in dichloromethane (15.00 mL) at 0 °C, followed by the addition of ethoxycarbonylmethylene triphenylphosphine (2.659 g, 7.632 mmol). The reaction system was slowly warmed to room temperature and stirred continuously for 15 minutes. Upon completion of the reaction, the reaction mixture was filtered through a pad of silica gel (using 30% ethyl acetate/petroleum ether as eluent) and the filtrate was concentrated under reduced pressure to afford ethyl 2-(oxetan-3-ylidene)acetate as a colorless viscous oil (815 mg, 79% yield). [00346] 1H NMR (400 MHz, CDCl3): δ 1.29 (t, 3H), 4.18 (q, 2H), 5.32-5.34 (m, 2H), 5.52-5.54 (m, 2H), 5.64-5.66 (m, 1H) ppm.

References

[1] Patent: WO2013/61205, 2013, A2. Location in patent: Page/Page column 67
[2] MedChemComm, 2016, vol. 7, # 10, p. 1925 - 1931
[3] Journal of Medicinal Chemistry, 2010, vol. 53, # 8, p. 3227 - 3246
[4] Tetrahedron Letters, 2014, vol. 55, # 28, p. 3805 - 3808
[5] Patent: WO2014/141118, 2014, A1. Location in patent: Page/Page column 42

ethyl 2-(oxetan-3-ylidene)acetate Preparation Products And Raw materials

Raw materials

Preparation Products

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ethyl 2-(oxetan-3-ylidene)acetate Suppliers

China 109 India 2 United Kingdom 1 United States 10 Global 122

Baimei Jihua (Henan) Pharmaceutical Technology Co., Ltd

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View Lastest Price from ethyl 2-(oxetan-3-ylidene)acetate manufacturers

Shanghai Rlavie Technology Co ltd

Product: ethyl 2-(oxetan-3-ylidene)acetate 922500-91-2
Price: US $0.00-0.00/KG
Min. Order: 1g
Purity: 98%min
Supply Ability: 500kg/month
Release date: 2021-11-18

Career Henan Chemical Co

Product: ethyl 2-(oxetan-3-ylidene)acetate 922500-91-2
Price: US $1.00/KG
Min. Order: 1KG
Purity: 95%
Supply Ability: 500KG
Release date: 2018-08-19

922500-91-2, ethyl 2-(oxetan-3-ylidene)acetateRelated Search:

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922500-91-2

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