ChemicalBook > CAS DataBase List > 5-(1H-Pyrrol-1-yl)-1H-benzo[d]imidazole-2-thiol

5-(1H-Pyrrol-1-yl)-1H-benzo[d]imidazole-2-thiol

Product Name
5-(1H-Pyrrol-1-yl)-1H-benzo[d]imidazole-2-thiol
CAS No.
172152-53-3
Chemical Name
5-(1H-Pyrrol-1-yl)-1H-benzo[d]imidazole-2-thiol
Synonyms
5-(1H-pyrrol-1-yl)-1H-benzo[d]iMidazole-2-thiol;Ilaprazole Impurity A;Ilaprazole Intermediate 2;Enavogliflozin Impurity 21;Ilaprazole intermediate P-3;5-Pyrrol-1-yl-1H-benzoimidazole-2-thiol;5-(1H-Pyroll-1-yl)-2-Mercaptobenzimidazole;5-(1H-Pyrrol-1-yl)-2-mercaptobenzimidazole;5-(1H-purrole-1-yl)-2-marcapto- benzimidazole;5-pyrrol-1-yl-1,3-dihydrobenzimidazole-2-thione
CBNumber
CB32521216
Molecular Formula
C11H9N3S
Formula Weight
215.27
MOL File
172152-53-3.mol
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5-(1H-Pyrrol-1-yl)-1H-benzo[d]imidazole-2-thiol Property

Boiling point:
381.7±44.0 °C(Predicted)
Density 
1.40
storage temp. 
2-8°C
solubility 
DMSO (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)
form 
Solid
pka
9.61±0.30(Predicted)
color 
White to Pale Green
InChI
InChI=1S/C11H9N3S/c15-11-12-9-4-3-8(7-10(9)13-11)14-5-1-2-6-14/h1-7H,(H2,12,13,15)
InChIKey
YYXGYVYKGRUILQ-UHFFFAOYSA-N
SMILES
C1(=S)NC2=CC=C(N3C=CC=C3)C=C2N1
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

American Custom Chemicals Corporation
Product number
CHM0390405
Product name
5-(1H-PYRROL-1-YL)-1H-BENZO[D]IMIDAZOLE-2-THIOL
Purity
95.00%
Packaging
5MG
Price
$504.94
Updated
2021/12/16
Alichem
Product number
172152533
Product name
5-(1H-Pyrrol-1-yl)-1H-benzo[d]imidazole-2-thiol
Packaging
1g
Price
$400
Updated
2021/12/16
Chemenu
Product number
CM162085
Product name
5-(1H-Pyrrol-1-yl)-2-mercaptobenzimidazole
Purity
95%
Packaging
5g
Price
$777
Updated
2021/12/16
Crysdot
Product number
CD11233680
Product name
5-(1H-Pyrrol-1-yl)-1H-benzo[d]imidazole-2-thiol
Purity
95+%
Packaging
5g
Price
$831
Updated
2021/12/16
AccelPharmtech
Product number
A7973
Product name
1,3-dihydro-5-(1H-pyrrol-1-yl)-2H-Benzimidazole-2-thione
Purity
97.00%
Packaging
1G
Price
$1740
Updated
2021/12/16
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5-(1H-Pyrrol-1-yl)-1H-benzo[d]imidazole-2-thiol Chemical Properties,Usage,Production

Uses

5-(1H-Pyrrol-1-yl)-2-mercaptobenzimidazole is a pharmaceutical intermediate compound used in the synthesis of various drugs such as ilaprazole, gastric and ulcer drugs.

Synthesis

Water (100ml) and anhydrous sodium acetate (16.02g, 0.20mole) were added, and then 2-mercapto-5- aminobenzimidazole (32.27g, 0.20mole),2,5-dimethoxytetrahydrofuran (28.4g, 0.21mole), and acetic acid (100ml) were added. Then, stirring was carried out at 5O℃ for 4 hours. The resultant product was cooled to 50C, and tetrahydrofuran (420ml) was added. The mixture was neutralized with a sodium hydroxide aqueous solution, and water (130ml) was added to carry out layer- separation. Then, an organic layer was washed with a sodium hydroxide aqueous solution. The organic layer was dried by anhydrous magnesium sulfate and concentrated, and then crystallized by ethyl acetate and n-hexane to provide a final compound, that is 5-(1H-Pyrrol-1-yl)-1H-benzo[d]imidazole-2-thiol. Yield: 35.7g (85%)

5-(1H-Pyrrol-1-yl)-1H-benzo[d]imidazole-2-thiol Preparation Products And Raw materials

Raw materials

Preparation Products

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5-(1H-Pyrrol-1-yl)-1H-benzo[d]imidazole-2-thiol Suppliers

China 191 India 6 United Kingdom 1 United States 1 Global 199
Carbosynth Limited
Tel
--
Fax
--
Email
sales@carbosynth.com
Country
United Kingdom
ProdList
6581
Advantage
61
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View Lastest Price from 5-(1H-Pyrrol-1-yl)-1H-benzo[d]imidazole-2-thiol manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD
Product
5-(1H-Pyrrol-1-yl)-2-mercaptobenzimidazole 172152-53-3
Price
US $0.00/Kg/Drum
Min. Order
1KG
Purity
98%min
Supply Ability
10 tons
Release date
2021-08-09
Shaanxi Dideu Medichem Co. Ltd
Product
5-(1H-Pyrrol-1-yl)-2-mercaptobenzimidazole 172152-53-3
Price
US $0.10/KG
Min. Order
1KG
Purity
99.0%
Supply Ability
1000 tons
Release date
2020-04-24
Zhuhai Hairuide Bioscience and Technology Co., Ltd
Product
5-(1H-Pyrrol-1-yl)-2-mercaptobenzimidazole 172152-53-3
Price
US $0.00/KG Ton
Min. Order
1KG Ton
Purity
99%+
Supply Ability
2 tons/month
Release date
2022-10-09

172152-53-3, 5-(1H-Pyrrol-1-yl)-1H-benzo[d]imidazole-2-thiolRelated Search:

Succinimide

  • 5-(1H-pyrrol-1-yl)-1H-benzo[d]iMidazole-2-thiol
  • 1,3-dihydro-5-(1H-pyrrol-1-yl)-2H-Benzimidazole-2-thione
  • 5-pyrrol-1-yl-1,3-dihydrobenzimidazole-2-thione
  • 5-(1H-Pyrrol-1-yl)-2-mercaptobenzimidazole
  • 2H-Benzimidazole-2-thione, 1,3-dihydro-5-(1H-pyrrol-1-yl)-
  • 5-(1H-purrole-1-yl)-2-marcapto- benzimidazole
  • Ilaprazole Intermediate 2
  • 5-Pyrrol-1-yl-1H-benzoimidazole-2-thiol
  • 5- (1H pyrrolidine-1-yl) -2-mercaptobenzimidazole
  • 5-(1H-Pyroll-1-yl)-2-Mercaptobenzimidazole
  • 5-(1H-pyrrol-1-yl)-1H-benzo[d]imidazole-2(3H)-thione
  • Ilaprazole intermediate P-3
  • Enavogliflozin Impurity 21
  • Ilaprazole Impurity A
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