ChemicalBook > CAS DataBase List > 4-Methylphenyl isothiocyanate

4-Methylphenyl isothiocyanate

Product Name
4-Methylphenyl isothiocyanate
CAS No.
622-59-3
Chemical Name
4-Methylphenyl isothiocyanate
Synonyms
AKOS BBS-00004440;TIMTEC-BB SBB008290;P-TOLYL ISOTHIOCYANATE;4-TOLYL ISOTHIOCYANATE;p-TolylIsothiocyanate>P-toluene isothiocyanate;p-Tolylisothiocyanate,97%;p-Tolyl isothiocyanate 97%;p-Tolyl isothiocyanate,99%;4-METHYLPHENYL ISOTHIOCYANATE
CBNumber
CB3252639
Molecular Formula
C8H7NS
Formula Weight
149.21
MOL File
622-59-3.mol
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4-Methylphenyl isothiocyanate Property

Melting point:
25-26 °C (lit.)
Boiling point:
237 °C (lit.) 62 °C/0.3 mmHg (lit.)
Density 
1.1442 (rough estimate)
refractive index 
n20/D 1.6345(lit.)
Flash point:
107 °C
storage temp. 
Store below +30°C.
form 
powder to lump
color 
White to Light yellow
Water Solubility 
MAY DECOMPOSE
Sensitive 
Moisture Sensitive
BRN 
386032
InChIKey
ABQKHKWXTUVKGF-UHFFFAOYSA-N
CAS DataBase Reference
622-59-3(CAS DataBase Reference)
NIST Chemistry Reference
Benzene, 1-isothiocyanato-4-methyl-(622-59-3)
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Safety

Hazard Codes 
Xn,T
Risk Statements 
36/37/38-42-42/43-23/24/25
Safety Statements 
22-26-36-45-36/37/39
RIDADR 
UN 2811 6.1/PG 2
WGK Germany 
3
RTECS 
NX9500000
F 
10-21
HazardClass 
6.1
PackingGroup 
III
HS Code 
29309090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H315Causes skin irritation

H317May cause an allergic skin reaction

H319Causes serious eye irritation

H334May cause allergy or asthma symptoms or breathing difficulties if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
253715
Product name
p-Tolyl isothiocyanate
Purity
97%
Packaging
5g
Price
$57.2
Updated
2024/03/01
TCI Chemical
Product number
I0393
Product name
p-Tolyl Isothiocyanate
Purity
>98.0%(GC)
Packaging
5g
Price
$56
Updated
2024/03/01
TCI Chemical
Product number
I0393
Product name
p-Tolyl Isothiocyanate
Purity
>98.0%(GC)
Packaging
25g
Price
$167
Updated
2024/03/01
Alfa Aesar
Product number
A11499
Product name
p-Tolyl isothiocyanate, 97%
Packaging
5g
Price
$46
Updated
2024/03/01
Alfa Aesar
Product number
A11499
Product name
p-Tolyl isothiocyanate, 97%
Packaging
25g
Price
$122.65
Updated
2024/03/01
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4-Methylphenyl isothiocyanate Chemical Properties,Usage,Production

Chemical Properties

clear light yellow liquid after melting

Uses

p-Tolyl isothiocyanate has been used in the preparation of 6-[1-amino-3-(p-tolyl)-thiourea]-2-ethylbenzo[de]isoquinoline-1,3-dione. It is used as capping agent to cap the N-terminal ends of polypeptide. It is also used as pharmaceutical intermediate.

Uses

p-Tolyl isothiocyanate has been used:

  • in the preparation of 6-[1-amino-3-(p-tolyl)-thiourea]-2-ethylbenzo[de]isoquinoline-1,3-dione
  • as capping agent to cap the N-terminal ends of polypeptides

General Description

p-Tolyl isothiocyanate reacts with 6-hydroxy-2,4,5-triaminopyrimidine or with 4,5,6-triaminopyrimidine in DMF and triethylamine to yield 2,4-diamino-5-(p-tolylthioureido)aminopyrimidin-6-one and 4,6-diamino-5-(tolylthioureido)aminopyrimidine, respectively.

4-Methylphenyl isothiocyanate Preparation Products And Raw materials

Raw materials

Preparation Products

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4-Methylphenyl isothiocyanate Suppliers

Americas 1 Belgium 2 China 74 Europe 1 Germany 4 India 3 Japan 3 Poland 1 Slovakia 1 Switzerland 2 United Kingdom 10 United States 20 Global 122
Manchester Organics
Tel
--
Fax
--
Email
info@manchesterorganics.com
Country
United Kingdom
ProdList
6834
Advantage
67
Apollo Scientific Ltd.
Tel
--
Fax
--
Email
sales@apolloscientific.co.uk
Country
United Kingdom
ProdList
6084
Advantage
88
MOLEKULA Ltd.
Tel
--
Fax
--
Email
kevinbanks@molekula.com
Country
United Kingdom
ProdList
6140
Advantage
66
CARBONE SCIENTIFIC CO.,LTD
Tel
--
Fax
--
Email
sales@carbonesci.com
Country
United Kingdom
ProdList
6666
Advantage
30
ARIAC - Armenian Institute of Applied Chemistry
Tel
--
Fax
--
Email
ariac@web.am
Country
United Kingdom
ProdList
2466
Advantage
46
Eurolabs Limited
Tel
--
Fax
--
Country
United Kingdom
ProdList
6309
Advantage
46
Fluorochem Ltd
Tel
--
Fax
--
Email
vernam@fluorochem.co.uk
Country
United Kingdom
ProdList
6375
Advantage
65
MDA Chemicals Ltd.
Tel
--
Fax
--
Email
sheila@mda-chem.co.uk
Country
United Kingdom
ProdList
1961
Advantage
30
Fluorochem Ltd.
Tel
--
Fax
--
Email
enquiries@fluorochem.co.uk
Country
United Kingdom
ProdList
6401
Advantage
74
VWR International
Tel
--
Fax
--
Email
solutions@vwr.com
Country
United Kingdom
ProdList
6548
Advantage
82
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View Lastest Price from 4-Methylphenyl isothiocyanate manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
4-Methylphenyl isothiocyanate 622-59-3
Price
US $0.00-0.00/KG
Min. Order
10mg
Purity
99%HPLC
Supply Ability
2000tons
Release date
2020-01-19
Career Henan Chemical Co
Product
4-Methylphenyl isothiocyanate 622-59-3
Price
US $9.80/KG
Min. Order
1g
Purity
≥99%
Supply Ability
100kg
Release date
2020-01-08

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