2,2-Dimethyl-5-(hydroxymethyl)-1,3-dixoane
- Product Name
- 2,2-Dimethyl-5-(hydroxymethyl)-1,3-dixoane
- CAS No.
- 4728-12-5
- Chemical Name
- 2,2-Dimethyl-5-(hydroxymethyl)-1,3-dixoane
- Synonyms
- (2,2-Dimethyl-1,3-dioxan-5-yl)methanol;(2,2-Dimethyl-1,3-dioxan-5-yl);1,3-Dioxane-5-Methanol,2,2-diMethyl-;5-HydroxyMethyl-2,2-diMethyl-1,3-dioxane;2,2-Dimethyl-5-(hydroxymethyl)-1,3-dixoane
- CBNumber
- CB32534331
- Molecular Formula
- C7H14O3
- Formula Weight
- 146.18
- MOL File
- 4728-12-5.mol
2,2-Dimethyl-5-(hydroxymethyl)-1,3-dixoane Property
- Melting point:
- 197-198℃
- Boiling point:
- 208℃
- Density
- 1.004
- Flash point:
- 96℃
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- 14.58±0.10(Predicted)
- Appearance
- Colorless to light yellow Liquid
- InChI
- InChI=1S/C7H14O3/c1-7(2)9-4-6(3-8)5-10-7/h6,8H,3-5H2,1-2H3
- InChIKey
- BTAUZIVCHJIXAX-UHFFFAOYSA-N
- SMILES
- O1CC(CO)COC1(C)C
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- Z4775
- Product name
- (2,2-Dimethyl-1,3-dioxan-5-yl)methanol
- Packaging
- 1g
- Price
- $47
- Updated
- 2021/12/16
- Product number
- FD144048
- Product name
- (2,2-Dimethyl-1,3-dioxan-5-yl)methanol
- Packaging
- 2g
- Price
- $80
- Updated
- 2021/12/16
- Product number
- J96319
- Product name
- (2,2-Dimethyl-1,3-dioxan-5-yl)methanol
- Packaging
- 5g
- Price
- $100
- Updated
- 2021/12/16
- Product number
- FD144048
- Product name
- (2,2-Dimethyl-1,3-dioxan-5-yl)methanol
- Packaging
- 5G
- Price
- $150
- Updated
- 2021/12/16
- Product number
- FD144048
- Product name
- (2,2-Dimethyl-1,3-dioxan-5-yl)methanol
- Packaging
- 10g
- Price
- $230
- Updated
- 2021/12/16
2,2-Dimethyl-5-(hydroxymethyl)-1,3-dixoane Chemical Properties,Usage,Production
Synthesis
4704-94-3
77-76-9
4728-12-5
Example 25 Synthesis of 1-(3-(3-hydroxy-2-(hydroxymethyl)propoxy)-4-methyl-1-phenyl-1H-pyrazol-5-yl)-3-(2-phenyl-8-(trifluoromethyl)imidazo[1,2-a]pyridin-3-yl)urea Step A: Preparation of (2,2-dimethyl-1,3-dioxan-5-yl)methanol: To a suspension of 2-hydroxymethyl-1,3-propanediol (5.0 g, 47.1 mmol) in THF (100 mL) was added p-toluenesulfonic acid (pTsOH, 269 mg, 1.41 mmol), followed by 2,2-dimethoxypropane (6.72 mL. 54.7 mmol). The reaction mixture was stirred at room temperature for 3 hours, then p-toluenesulfonic acid (200 mg) was added and stirring was continued at room temperature for 48 hours. Upon completion of the reaction, triethylamine (3 mL) was added to neutralize the reaction system and the mixture was subsequently concentrated under reduced pressure. The residue was purified by silica gel column chromatography using 5% methanol/dichloromethane as eluent to afford (2,2-dimethyl-1,3-dioxan-5-yl) methanol (5.04 g, 73% yield) as a colorless liquid.1H NMR (CDCl3) δ 4.02 (dd, J = 12.0, 4.1 Hz, 2H), 3.74-3.80 (m, 4H), and 1.90 (t, J = 5.1 Hz, 1H), 1.78-1.88 (m, 1H), 1.45 (s, 3H), 1.40 (s, 3H) ppm.
References
[1] Journal of Medicinal Chemistry, 2002, vol. 45, # 26, p. 5694 - 5709
[2] Patent: WO2008/157726, 2008, A1. Location in patent: Page/Page column 210
[3] Patent: EP2103611, 2009, A1. Location in patent: Page/Page column 51-52
[4] Patent: WO2008/124703, 2008, A2. Location in patent: Page/Page column 84
[5] Journal of Medicinal Chemistry, 1990, vol. 33, # 1, p. 187 - 196
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View Lastest Price from 2,2-Dimethyl-5-(hydroxymethyl)-1,3-dixoane manufacturers
- Product
- 2,2-dimethyl-5-hydroxymethyl-1,3-dioxane 4728-12-5
- Price
- US $1.00-22.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100000KG
- Release date
- 2024-08-09