4-Iodo Suberoylanilide HydroxaMic Acid

Product Name: 4-Iodo Suberoylanilide HydroxaMic Acid
CAS No.: 1219807-87-0
Chemical Name: 4-Iodo Suberoylanilide HydroxaMic Acid
Synonyms: 4-iodo-SAHA;4-Iodo Suberoylanilide HydroxaMic Acid;N1-Hydroxy-N8-(4-iodophenyl)octanediaMide;Octanediamide, N1-hydroxy-N8-(4-iodophenyl)-
CBNumber: CB32544804
Molecular Formula: C14H19IN2O3
Formula Weight: 390.22
MOL File: 1219807-87-0.mol

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4-Iodo Suberoylanilide HydroxaMic Acid Property

Density: 1.579±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: insoluble in H2O; insoluble in EtOH; ≥1.67 mg/mL in DMSO
form: A crystalline solid
pka: 9.48±0.20(Predicted)

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 10495
Product name: 4-iodo-SAHA
Purity: ≥98%
Packaging: 50mg
Price: $89
Updated: 2024/03/01

Cayman Chemical

Product number: 10495
Product name: 4-iodo-SAHA
Purity: ≥98%
Packaging: 100mg
Price: $168
Updated: 2024/03/01

Cayman Chemical

Product number: 10495
Product name: 4-iodo-SAHA
Purity: ≥98%
Packaging: 250mg
Price: $395
Updated: 2024/03/01

Cayman Chemical

Product number: 10495
Product name: 4-iodo-SAHA
Purity: ≥98%
Packaging: 500mg
Price: $700
Updated: 2024/03/01

TRC

Product number: I719800
Product name: 4-IodoSuberoylanilideHydroxamicAcid
Packaging: 100mg
Price: $155
Updated: 2021/12/16

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4-Iodo Suberoylanilide HydroxaMic Acid Chemical Properties,Usage,Production

Uses

A SAHA derivative with antiproliferative activity in several human cancer cell lines. Antitumor agent.

Biological Activity

4-iodo-saha is a hydrophobic derivative of saha, the class i and class ii histone deacetylase (hdac) inhibitor [1].the reversible acetylation of lysine residues in histone plays an important role in transcriptional activation and repression. the regulation of these post-translational modifications is balanced by histone acetyltransferase (hat) and histone deacetylase (hdac) activities. hdacs are also involved in reversible acetylation of non-histone proteins [1].4-iodo-saha is a histone deacetylase (hdac) inhibitor. in skbr3-breast-derived cell line, 4-iodo-saha inhibited cell proliferation with ec50 value of 1.1 μm. in ht29 colon-derived cell line, leukemia-derived u937 tumor cell line, ja16, hl60 and k562 cell lines, 4-iodo-saha inhibited cell proliferation with ec50 values of 0.95, 0.12, 0.24, 0.85 and 1.3 μm, respectively. 4-iodo-saha is 10-fold more potent as an inhibitor of u937 leukemia cell proliferation compared to saha (0.12 μm versus 1.2 μm). in skbr3 cells, 4-iodo-saha reduced acetylated h4 and p21 levels [1].

References

[1]. salmi-smail c, fabre a, dequiedt f, et al. modified cap group suberoylanilide hydroxamic acid histone deacetylase inhibitor derivatives reveal improved selective antileukemic activity. j med chem. 2010 apr 22;53(8):3038-47.

4-Iodo Suberoylanilide HydroxaMic Acid Preparation Products And Raw materials

Raw materials

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1219807-87-0, 4-Iodo Suberoylanilide HydroxaMic AcidRelated Search:

4-Iodo Suberoylanilide HydroxaMic Acid

4-iodo-SAHA

N1-Hydroxy-N8-(4-iodophenyl)octanediaMide

Octanediamide, N1-hydroxy-N8-(4-iodophenyl)-

1219807-87-0

C14H19IN2O3

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