4-Iodo Suberoylanilide HydroxaMic Acid
- Product Name
- 4-Iodo Suberoylanilide HydroxaMic Acid
- CAS No.
- 1219807-87-0
- Chemical Name
- 4-Iodo Suberoylanilide HydroxaMic Acid
- Synonyms
- 4-iodo-SAHA;4-Iodo Suberoylanilide HydroxaMic Acid;N1-Hydroxy-N8-(4-iodophenyl)octanediaMide;Octanediamide, N1-hydroxy-N8-(4-iodophenyl)-
- CBNumber
- CB32544804
- Molecular Formula
- C14H19IN2O3
- Formula Weight
- 390.22
- MOL File
- 1219807-87-0.mol
4-Iodo Suberoylanilide HydroxaMic Acid Property
- Density
- 1.579±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- insoluble in H2O; insoluble in EtOH; ≥1.67 mg/mL in DMSO
- form
- A crystalline solid
- pka
- 9.48±0.20(Predicted)
N-Bromosuccinimide Price
- Product number
- 10495
- Product name
- 4-iodo-SAHA
- Purity
- ≥98%
- Packaging
- 50mg
- Price
- $89
- Updated
- 2024/03/01
- Product number
- 10495
- Product name
- 4-iodo-SAHA
- Purity
- ≥98%
- Packaging
- 100mg
- Price
- $168
- Updated
- 2024/03/01
- Product number
- 10495
- Product name
- 4-iodo-SAHA
- Purity
- ≥98%
- Packaging
- 250mg
- Price
- $395
- Updated
- 2024/03/01
- Product number
- 10495
- Product name
- 4-iodo-SAHA
- Purity
- ≥98%
- Packaging
- 500mg
- Price
- $700
- Updated
- 2024/03/01
- Product number
- 014903
- Product name
- 4-Iodo Suberoylanilide Hydroxamic Acid
- Packaging
- 100mg
- Price
- $446
- Updated
- 2021/12/16
4-Iodo Suberoylanilide HydroxaMic Acid Chemical Properties,Usage,Production
Uses
A SAHA derivative with antiproliferative activity in several human cancer cell lines. Antitumor agent.
Biological Activity
4-iodo-saha is a hydrophobic derivative of saha, the class i and class ii histone deacetylase (hdac) inhibitor [1].the reversible acetylation of lysine residues in histone plays an important role in transcriptional activation and repression. the regulation of these post-translational modifications is balanced by histone acetyltransferase (hat) and histone deacetylase (hdac) activities. hdacs are also involved in reversible acetylation of non-histone proteins [1].4-iodo-saha is a histone deacetylase (hdac) inhibitor. in skbr3-breast-derived cell line, 4-iodo-saha inhibited cell proliferation with ec50 value of 1.1 μm. in ht29 colon-derived cell line, leukemia-derived u937 tumor cell line, ja16, hl60 and k562 cell lines, 4-iodo-saha inhibited cell proliferation with ec50 values of 0.95, 0.12, 0.24, 0.85 and 1.3 μm, respectively. 4-iodo-saha is 10-fold more potent as an inhibitor of u937 leukemia cell proliferation compared to saha (0.12 μm versus 1.2 μm). in skbr3 cells, 4-iodo-saha reduced acetylated h4 and p21 levels [1].
References
[1]. salmi-smail c, fabre a, dequiedt f, et al. modified cap group suberoylanilide hydroxamic acid histone deacetylase inhibitor derivatives reveal improved selective antileukemic activity. j med chem. 2010 apr 22;53(8):3038-47.