TCS 21311
- Product Name
- TCS 21311
- CAS No.
- 1260181-14-3
- Chemical Name
- TCS 21311
- Synonyms
- NIBR-3049;TCS 21311;TCS21311; TCS-21311;JAK3/GSK-3β/PKCα Inhibitor - CAS 1260181-14-3 - Calbiochem;3-{5-[4-(2-hydroxy-2-methylpropionyl)piperazin-1-yl]-2-trifluoromethylphenyl}-4-(1H-indol-3-yl)pyrrole-2,5-dione;3-(5-(4-(2-Hydroxy-2-methylpropanoyl)piperazin-1-yl)-2-(trifluoromethyl)phenyl)-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione;3-[5-[4-(2-Hydroxy-2-Methyl-1-oxopropyl)-1-piperazinyl]-2-(trifluoroMethyl)phenyl]-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione;1H-Pyrrole-2,5-dione, 3-[5-[4-(2-hydroxy-2-methyl-1-oxopropyl)-1-piperazinyl]-2-(trifluoromethyl)phenyl]-4-(1H-indol-3-yl)-;Protein kinase C,TCS 21311,Glycogen synthase kinase 3,NIBR 3049,TCS21311,GSK-3,Glycogen synthase kinase-3,Inhibitor,JAK,inhibit,NIBR-3049,TCS-21311,Janus kinase,PKC
- CBNumber
- CB32546792
- Molecular Formula
- C27H25F3N4O4
- Formula Weight
- 526.51
- MOL File
- 1260181-14-3.mol
TCS 21311 Property
- Boiling point:
- 793.0±60.0 °C(Predicted)
- Density
- 1.436±0.06 g/cm3(Predicted)
- storage temp.
- +2C to +8C
- solubility
- <52.65mg/ml in DMSO
- form
- Yellow solid
- pka
- 7.91±0.60(Predicted)
- color
- White to yellow
N-Bromosuccinimide Price
- Product number
- 420148
- Product name
- JAK3/GSK-3β/PKCα Inhibitor - CAS 1260181-14-3 - Calbiochem
- Packaging
- 5mg
- Price
- $303
- Updated
- 2024/03/01
- Product number
- 4221
- Product name
- TCS21311
- Purity
- ≥98%(HPLC)
- Packaging
- 10
- Price
- $271
- Updated
- 2021/12/16
- Product number
- 4221
- Product name
- TCS21311
- Purity
- ≥98%(HPLC)
- Packaging
- 50
- Price
- $1088
- Updated
- 2021/12/16
- Product number
- 021302
- Product name
- TCS-21311
- Packaging
- 10mg
- Price
- $460
- Updated
- 2021/12/16
- Product number
- 256874
- Product name
- TCS 21311
- Packaging
- 10mg
- Price
- $573
- Updated
- 2021/12/16
TCS 21311 Chemical Properties,Usage,Production
Uses
A potent JAK3 inhibitor; selective for JAK3 over JAK1, JAK2 and TYK2. It also inhibits GSK-3β, PKCα and PKCθ.
Biological Activity
tcs 21311 is a potent and selective jak3 inhibitor with the ic50 values of 8 nm. tcs 21311 shows high selectivity for jak3 over jak1, jak2 and tyk2. the ic50 values are 1017, 2550 and 8055 nm respectively. tcs 21311 exihibits inhibitory effect on gsk-3β, pkcα and pkcθ with the ic50 values of 3, 13 and 68 nm, respectively [1].janus kinases (jak) belong to a small family of cytoplasmic protein tyrosine kinases including jak1, jak2, tyk2, and jak3, which play important roles in initiating the cytokine-triggered signaling events by activators of transcription (stat) proteins via tyrosine phosphorylation [2]. due to its association with relevant cytokine signaling pathways, jak3 serves as an important target for therapeutic intervention in the treatment of inflammatory diseases, autoimmune disorders and organ transplant rejection [2].
storage
Desiccate at RT
References
[1] thoma g, nuninger f, falchetto r, et al. identification of a potent janus kinase 3 inhibitor with high selectivity within the janus kinase family[j]. journal of medicinal chemistry, 2010, 54(1): 284-288.
[2] clark m p, george k m, bookland r g, et al. development of new pyrrolopyrimidine-based inhibitors of janus kinase 3 (jak3)[j]. bioorganic & medicinal chemistry letters, 2007, 17(5): 1250-1253.
TCS 21311 Preparation Products And Raw materials
Raw materials
Preparation Products
TCS 21311 Suppliers
- Tel
- --
- Fax
- --
- info@trc-canada.com
- Country
- Canada
- ProdList
- 6038
- Advantage
- 71