TCS 21311

Product Name: TCS 21311
CAS No.: 1260181-14-3
Chemical Name: TCS 21311
Synonyms: NIBR-3049;TCS 21311;TCS21311; TCS-21311;JAK3/GSK-3β/PKCα Inhibitor - CAS 1260181-14-3 - Calbiochem;3-{5-[4-(2-hydroxy-2-methylpropionyl)piperazin-1-yl]-2-trifluoromethylphenyl}-4-(1H-indol-3-yl)pyrrole-2,5-dione;3-[5-[4-(2-Hydroxy-2-Methyl-1-oxopropyl)-1-piperazinyl]-2-(trifluoroMethyl)phenyl]-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione;1H-Pyrrole-2,5-dione, 3-[5-[4-(2-hydroxy-2-methyl-1-oxopropyl)-1-piperazinyl]-2-(trifluoromethyl)phenyl]-4-(1H-indol-3-yl)-;Protein kinase C,TCS 21311,Glycogen synthase kinase 3,NIBR 3049,TCS21311,GSK-3,Glycogen synthase kinase-3,Inhibitor,JAK,inhibit,NIBR-3049,TCS-21311,Janus kinase,PKC
CBNumber: CB32546792
Molecular Formula: C27H25F3N4O4
Formula Weight: 526.51
MOL File: 1260181-14-3.mol

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TCS 21311 Property

Boiling point:: 793.0±60.0 °C(Predicted)
Density: 1.436±0.06 g/cm3(Predicted)
storage temp.: +2C to +8C
solubility: <52.65mg/ml in DMSO
form: Yellow solid
pka: 7.91±0.60(Predicted)

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 420148
Product name: JAK3/GSK-3β/PKCα Inhibitor - CAS 1260181-14-3 - Calbiochem
Packaging: 5mg
Price: $303
Updated: 2024/03/01

Tocris

Product number: 4221
Product name: TCS21311
Purity: ≥98%(HPLC)
Packaging: 10
Price: $271
Updated: 2021/12/16

Tocris

Product number: 4221
Product name: TCS21311
Purity: ≥98%(HPLC)
Packaging: 50
Price: $1088
Updated: 2021/12/16

Usbiological

Product number: 021302
Product name: TCS-21311
Packaging: 10mg
Price: $460
Updated: 2021/12/16

Usbiological

Product number: 256874
Product name: TCS 21311
Packaging: 10mg
Price: $573
Updated: 2021/12/16

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TCS 21311 Chemical Properties,Usage,Production

Uses

A potent JAK3 inhibitor; selective for JAK3 over JAK1, JAK2 and TYK2. It also inhibits GSK-3β, PKCα and PKCθ.

Biological Activity

tcs 21311 is a potent and selective jak3 inhibitor with the ic50 values of 8 nm. tcs 21311 shows high selectivity for jak3 over jak1, jak2 and tyk2. the ic50 values are 1017, 2550 and 8055 nm respectively. tcs 21311 exihibits inhibitory effect on gsk-3β, pkcα and pkcθ with the ic50 values of 3, 13 and 68 nm, respectively [1].janus kinases (jak) belong to a small family of cytoplasmic protein tyrosine kinases including jak1, jak2, tyk2, and jak3, which play important roles in initiating the cytokine-triggered signaling events by activators of transcription (stat) proteins via tyrosine phosphorylation [2]. due to its association with relevant cytokine signaling pathways, jak3 serves as an important target for therapeutic intervention in the treatment of inflammatory diseases, autoimmune disorders and organ transplant rejection [2].

storage

Desiccate at RT

References

[1] thoma g, nuninger f, falchetto r, et al. identification of a potent janus kinase 3 inhibitor with high selectivity within the janus kinase family[j]. journal of medicinal chemistry, 2010, 54(1): 284-288.
[2] clark m p, george k m, bookland r g, et al. development of new pyrrolopyrimidine-based inhibitors of janus kinase 3 (jak3)[j]. bioorganic & medicinal chemistry letters, 2007, 17(5): 1250-1253.

TCS 21311 Preparation Products And Raw materials

Raw materials

Preparation Products

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1260181-14-3, TCS 21311Related Search:

3-[5-[4-(2-Hydroxy-2-Methyl-1-oxopropyl)-1-piperazinyl]-2-(trifluoroMethyl)phenyl]-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione

TCS 21311

NIBR-3049

TCS21311; TCS-21311

JAK3/GSK-3β/PKCα Inhibitor - CAS 1260181-14-3 - Calbiochem

3-{5-[4-(2-hydroxy-2-methylpropionyl)piperazin-1-yl]-2-trifluoromethylphenyl}-4-(1H-indol-3-yl)pyrrole-2,5-dione

1H-Pyrrole-2,5-dione, 3-[5-[4-(2-hydroxy-2-methyl-1-oxopropyl)-1-piperazinyl]-2-(trifluoromethyl)phenyl]-4-(1H-indol-3-yl)-

Protein kinase C,TCS 21311,Glycogen synthase kinase 3,NIBR 3049,TCS21311,GSK-3,Glycogen synthase kinase-3,Inhibitor,JAK,inhibit,NIBR-3049,TCS-21311,Janus kinase,PKC

1260181-14-3

C27H25F3N4O4

Aromatics

Heterocycles

Inhibitors

Intermediates & Fine Chemicals

Pharmaceuticals