diMethyl 5-broMopyridine-2,3-dicarboxylate

Product Name: diMethyl 5-broMopyridine-2,3-dicarboxylate
CAS No.: 521980-82-5
Chemical Name: diMethyl 5-broMopyridine-2,3-dicarboxylate
Synonyms: DIMETHYL 5-BROMOPYRIDINE-2,3-D;dimethyl 5-bromopyridine-2,3-dicarboxylate - [D86883];2,3-Pyridinedicarboxylic acid, 5-bromo-, 2,3-dimethyl ester
CBNumber: CB32549627
Molecular Formula: C9H8BrNO4
Formula Weight: 274.07
MOL File: 521980-82-5.mol

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diMethyl 5-broMopyridine-2,3-dicarboxylate Property

Boiling point:: 315.0±37.0 °C(Predicted)
Density: 1.569±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
pka: -3.18±0.10(Predicted)
Appearance: White to off-white Solid
InChI: InChI=1S/C9H8BrNO4/c1-14-8(12)6-3-5(10)4-11-7(6)9(13)15-2/h3-4H,1-2H3
InChIKey: JYRYOIMMYLBBNZ-UHFFFAOYSA-N
SMILES: C1(C(OC)=O)=NC=C(Br)C=C1C(OC)=O

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H314Causes severe skin burns and eye damage

H412Harmful to aquatic life with long lasting effects

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P330+P331IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P363Wash contaminated clothing before reuse.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

AK Scientific

Product number: 7335AB
Product name: Dimethyl5-bromopyridine-2,3-dicarboxylate
Packaging: 250mg
Price: $317
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0360161
Product name: DIMETHYL-5-BROMOPYRIDINE-2,3-DICARBOXYLATE
Purity: 95.00%
Packaging: 5MG
Price: $501.28
Updated: 2021/12/16

AK Scientific

Product number: 7335AB
Product name: Dimethyl5-bromopyridine-2,3-dicarboxylate
Packaging: 1g
Price: $717
Updated: 2021/12/16

Chemenu

Product number: CM174055
Product name: dimethyl5-bromopyridine-2,3-dicarboxylate
Purity: 95%
Packaging: 10g
Price: $795
Updated: 2021/12/16

Crysdot

Product number: CD11111396
Product name: Dimethyl5-bromopyridine-2,3-dicarboxylate
Purity: 95+%
Packaging: 10g
Price: $850
Updated: 2021/12/16

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diMethyl 5-broMopyridine-2,3-dicarboxylate Chemical Properties,Usage,Production

Synthesis

67-56-1

89-00-9

521980-82-5

Concentrated sulfuric acid (10 mL) was slowly added to a methanolic (500 mL) suspension of 2,3-pyridinedicarboxylic acid (50 g, 300 mmol). The reaction mixture was heated to reflux for 48 hours and subsequently cooled to 40 °C and bromine (38 mL, 750 mmol) was added slowly and dropwise over 2 hours. The reaction mixture was continued to be heated at 55 °C for 48 h, followed by vacuum concentration. The concentrated residue was dissolved in isopropyl acetate (500 mL), and the resulting solution was washed sequentially with saturated aqueous sodium thiosulfate (200 mL x 4) and brine (400 mL), dried over anhydrous sodium sulfate, filtered, and concentrated again under vacuum. The residue was purified by silica gel column chromatography (petroleum ether/ethyl acetate, v/v=5/1) to afford dimethyl 5-bromo-pyridine-2,3-dicarboxylate as a yellow solid (52 g, 63% yield). Mass spectrum (ESI, positive ion mode) m/z: 274.0 [M + H]+; 1H NMR (400 MHz, CDCl3) δ (ppm): 8.75-8.76 (d, J = 2.2 Hz, 1H), 8.23-8.24 (d, J = 2.2 Hz, 1H), 3.93 (s, 3H), 3.89 (s, 3H).

References

[1] Patent: WO2014/89324, 2014, A1. Location in patent: Paragraph 0284
[2] Patent: CN104016979, 2017, B. Location in patent: Paragraph 0800; 0801; 0802; 0803
[3] Patent: US2012/122899, 2012, A1. Location in patent: Page/Page column 18
[4] Patent: WO2012/129013, 2012, A1. Location in patent: Page/Page column 29-30
[5] Patent: WO2013/169563, 2013, A1. Location in patent: Page/Page column 69; 70

diMethyl 5-broMopyridine-2,3-dicarboxylate Preparation Products And Raw materials

Raw materials

Preparation Products

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diMethyl 5-broMopyridine-2,3-dicarboxylate Suppliers

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521980-82-5, diMethyl 5-broMopyridine-2,3-dicarboxylateRelated Search:

DIMETHYL 5-BROMOPYRIDINE-2,3-D

2,3-Pyridinedicarboxylic acid, 5-bromo-, 2,3-dimethyl ester

dimethyl 5-bromopyridine-2,3-dicarboxylate - [D86883]

521980-82-5