3-Fluoro-5-Methylanisole
- Product Name
- 3-Fluoro-5-Methylanisole
- CAS No.
- 160911-11-5
- Chemical Name
- 3-Fluoro-5-Methylanisole
- Synonyms
- 5-Fluoro-3-methylanisole;3-Fluoro-5-Methylanisole;3-Fluoro-5-methoxytoluene;1-Fluoro-3-Methoxy-5-Methylbenzene;Benzene, 1-fluoro-3-methoxy-5-methyl-
- CBNumber
- CB32549809
- Molecular Formula
- C8H9FO
- Formula Weight
- 140.15
- MOL File
- 160911-11-5.mol
3-Fluoro-5-Methylanisole Property
- Boiling point:
- 164.2±20.0 °C(Predicted)
- Density
- 1.046±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- form
- liquid
- color
- Clear, Colourless
Safety
- HS Code
- 2909309090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
N-Bromosuccinimide Price
- Product number
- PC7519
- Product name
- 3-Fluoro-5-methylanisole
- Purity
- 99%
- Packaging
- 1g
- Price
- $63
- Updated
- 2021/12/16
- Product number
- 2707-3-10
- Product name
- 3-Fluoro-5-methylanisole
- Purity
- 99%
- Packaging
- 1g
- Price
- $69
- Updated
- 2021/12/16
- Product number
- PC7519
- Product name
- 3-Fluoro-5-methylanisole
- Purity
- 99%
- Packaging
- 5g
- Price
- $185
- Updated
- 2021/12/16
- Product number
- 2707-3-10
- Product name
- 3-Fluoro-5-methylanisole
- Purity
- 99%
- Packaging
- 5G
- Price
- $204
- Updated
- 2021/12/16
- Product number
- A117469
- Product name
- 1-Fluoro-3-methoxy-5-methylbenzene
- Purity
- 98%
- Packaging
- 1g
- Price
- $37
- Updated
- 2021/12/16
3-Fluoro-5-Methylanisole Chemical Properties,Usage,Production
Uses
3-Fluoro-5-Methylanisole is utilized in various applications, including the production of pharmaceuticals, fragrances, and other fine chemicals.
Synthesis
823-96-1
29578-39-0
160911-11-5
General procedure for the synthesis of 1-fluoro-3-methoxy-5-methylbenzene from trimethylcyclotriboroxane and 3-bromo-5-fluoroanisole (Example 40): (40a) Synthesis of 1-fluoro-3-methoxy-5-methylbenzene 3-Bromo-5-fluoroanisole (2.05 g, 10 mmol), trimethylcyclotriboroxane (50% THF solution, 2.51 g, 20 mmol), PdCl2(dppf) (0.82 g, 1.0 mmol), and cesium carbonate (6.52 g, 20 mmol) were dissolved in a solvent mixture of dioxane (100 mL) and water (50 mL). It was heated and stirred under reflux conditions for 10 hours. Upon completion of the reaction, it was cooled to room temperature and water (100 mL) was added to the reaction solution, which was then extracted twice with ethyl acetate (200 mL). The organic layers were combined, washed twice with water (100 mL) and dried over anhydrous sodium sulfate. After concentration under reduced pressure, the residue was purified by silica gel column chromatography (eluent: hexane/ethyl acetate, 6:1) to afford 1-fluoro-3-methoxy-5-methylbenzene (1.40 g, yield: 66%) as a yellow oil. 1H-NMR (CDCl3, 400 MHz) δ: 1.78 (3H, s), 6.44 (1H, dd, J = 2.0, 11.0 Hz), 6.50 (1H, d, J = 11.0 Hz), 6.51 (1H, s).
References
[1] Patent: EP2138484, 2009, A1. Location in patent: Page/Page column 44
3-Fluoro-5-Methylanisole Preparation Products And Raw materials
Raw materials
Preparation Products
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