ChemicalBook > CAS DataBase List > (R,R,R)-Aprepitant

(R,R,R)-Aprepitant

Product Name
(R,R,R)-Aprepitant
CAS No.
1148113-53-4
Chemical Name
(R,R,R)-Aprepitant
Synonyms
Aprepitant A;(R,R,R)-Aprepitant;(1R,2R,3R)-Aprepitant;"1R,2R,2R Aprepitant";Aprepitant impurity 04;Aprepitant EP Impurity E;Aprepitant Related CoMpound A;Aprepitant trans-1-enantiomer;Aprepitant USP RC A (R,R,R-Diasteromer);Aprepitant EP Impurity E/ (R,R,R)-Aprepitant
CBNumber
CB32557888
Molecular Formula
C23H21F7N4O3
Formula Weight
534.43
MOL File
1148113-53-4.mol
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(R,R,R)-Aprepitant Property

Density 
1.51±0.1 g/cm3(Predicted)
pka
8.06±0.20(Predicted)
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Safety

HS Code 
2934990002
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H413May cause long lasting harmful effects to aquatic life

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
1041915
Product name
Aprepitant Related Compound A
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
10MG
Price
$1300
Updated
2024/03/01
TRC
Product number
A729785
Product name
(R,R,R)-Aprepitant
Packaging
25mg
Price
$5095
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0027120
Product name
APREPITANT RELATED COMPOUND A
Purity
95.00%
Packaging
5MG
Price
$504.12
Updated
2021/12/16
AK Scientific
Product number
6464EM
Product name
(R,R,R)-Aprepitant
Packaging
2mg
Price
$590
Updated
2021/12/16
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(R,R,R)-Aprepitant Chemical Properties,Usage,Production

Uses

(R,R,R)-Aprepitant (Aprepitant EP Impurity E) is the (R,R,R)-enantiomer of Aprepitant (A729800), the key intermediate of Aprepitant in bulk drug and formulation samples of Aprepitant.

Application

(R,R,R)-Aprepitant (Aprepitant Related Compound A) is a USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia.

(R,R,R)-Aprepitant Preparation Products And Raw materials

Raw materials

Preparation Products

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(R,R,R)-Aprepitant Suppliers

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1148113-53-4, (R,R,R)-AprepitantRelated Search:

Aprepitant Aprepitant Atorvastatin Related Compound D (20 mg) (Epoxide impurity, or 3-(4-Fluorobenzoyl)-2-isobutyryl-3-phenyl-oxirane-2- carboxylic acid phenylamide) Atorvastatin Ethyl Ester Atorvastatin Related Compound C Atorvastatin Methyl Ester Atorvastatin Epoxy Tetrahydrofuran IMpurity Atorvastatin Acetonide Atenolol 2-[4-(2,3-DIHYDROXYPROPOXY)PHENYL]ACETAMIDE Atorvastatin N-(3,5-Dihydroxy-7-heptanoic Acid)amide Atorvastatin tert-Butyl Ester 2,3-Dehydroxy Atorvastatin Sodium Salt 3S,5R isoMer, or (3S,5R)-7-[3-(phenylcarbaMoyl)-5-(4-fluorophenyl)-2-isopropyl-4-phenyl-1H-pyrrol-1-yl]-3,5-dihydroxyheptanoic acid calciuM salt O-Methyl Atorvastatin Calcium Salt 5-[[(2S,3R)-2-[(1S)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholin-4-yl]methyl]-1,2-dihydro-1,2,4-triazol-3-one Aprepitant Impurity 11 HCl Aprepitant Impurity 2

  • (R,R,R)-Aprepitant
  • Aprepitant trans-1-enantiomer
  • Aprepitant Related Compound A (10 mg) (3-[[(2R,3R)-2-[(R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholino]methyl]-1H-1,2,4-triazol-5(4H)-one)
  • 5-[[(2R,3R)-2-[(1R)-1-[3,5-Bis(trifluoroMethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-4-Morpholinyl]Methyl]-1,2-dihydro-3H-1,2,4-triazol-3-one
  • Aprepitant Related CoMpound A
  • Aprepitant EP Impurity E
  • Aprepitant A
  • Aprepitant USP RC A (R,R,R-Diasteromer)
  • (1R,2R,3R)-Aprepitant
  • 3-(((2R,3R)-2-((R)-1-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(4-fluorophenyl)morpholino)methyl)-1H-1,2,4-triazol-5(4H)-one
  • Aprepitant impurity 5/Aprepitant EP Impurity E
  • Aripitant related substance A reference substance
  • 3H-1,2,4-Triazol-3-one, 5-[[(2R,3R)-2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-4-morpholinyl]methyl]-1,2-dihydro-
  • 5-(((2R,3R)-2-((R)-1-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(4-fluorophenyl)morpholino)methyl)-2,4-dihydro-3H-1,2,4-triazol-3-one
  • Aprepitant EP Impurity E/ (R,R,R)-Aprepitant
  • "1R,2R,2R Aprepitant"
  • Aprepitant Related Compound A (3-[[(2R,3R)-2-[(R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fl (1041915)
  • Aprepitant(R,R,R)-Isomer（Azilsartan Impurity 41）
  • Aprepitant impurity 04
  • Aprepitant RRR isomer (diastearomer)-(5-(((2R,3R)-2-((R)-1-(3,5-bis(trifluoromethyl)phenyl) ethoxy)-3-(4-fluorophenyl) morpholino)methyl)-1,2-dihydro-1,2,4-triazol-3-one)
  • 3-[[(2R,3R)-2-[(R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholino]methyl]-1H
  • 1148113-53-4
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