Atorvastatin tert-Butyl Ester

Product Name: Atorvastatin tert-Butyl Ester
CAS No.: 134395-00-9
Chemical Name: Atorvastatin tert-Butyl Ester
Synonyms: Atorvastatin t-butyl ester;(3R,5R);Atorvastatin 1;Atorvastatin calcium-8;Atorvastatin Impurity 21;Atorvastatin EP Impurity N;ATV imp N ( tertbutyl ester);Atorvastatin tert-Butyl Ester;Atorvastatin Calcium Impurity N;Atorvastatin calcium impurity 15
CBNumber: CB21176137
Molecular Formula: C37H43FN2O5
Formula Weight: 614.75
MOL File: 134395-00-9.mol

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Atorvastatin tert-Butyl Ester Property

Melting point:: 66-68°C
Boiling point:: 721.0±60.0 °C(Predicted)
Density: 1.16
storage temp.: 2-8°C
solubility: Chloroform (Slightly), DMSO (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)
form: Solid
pka: 13.57±0.70(Predicted)
color: White to Off-White
PH: 6.22 at 25℃ and 10mg/L
Major Application: pharmaceutical small molecule
InChIKey: GCPKKGVOCBYRML-LOYHVIPDSA-N
SMILES: Fc1ccc(cc1)c2[n](c(c(c2c4ccccc4)C(=O)Nc3ccccc3)C(C)C)CC[C@@H](O)C[C@@H](O)CC(=O)OC(C)(C)C
CAS DataBase Reference: 134395-00-9

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Safety

WGK Germany: WGK 2
Storage Class: 11 - Combustible Solids
Hazard Classifications: Aquatic Chronic 2
STOT RE 2

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H413May cause long lasting harmful effects to aquatic life

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P273Avoid release to the environment.

P314Get medical advice/attention if you feel unwell.

P391Collect spillage. Hazardous to the aquatic environment

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC

Product number: A791740
Product name: (βR,δR)-Atorvastatintert-ButylEster(>90%)
Packaging: 10mg
Price: $105
Updated: 2021/12/16

TRC

Product number: A791740
Product name: (βR,δR)-Atorvastatintert-ButylEster(>90%)
Packaging: 100mg
Price: $715
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0026619
Product name: ATORVASTATIN TERT-BUTYL ESTER
Purity: 95.00%
Packaging: 1MG
Price: $721.88
Updated: 2021/12/16

AK Scientific

Product number: 6189AA
Product name: Atorvastatintert-butylester
Packaging: 5g
Price: $321
Updated: 2021/12/16

AK Scientific

Product number: 6189AA
Product name: Atorvastatintert-butylester
Packaging: 10g
Price: $554
Updated: 2021/12/16

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Atorvastatin tert-Butyl Ester Chemical Properties,Usage,Production

Chemical Properties

Off-white to pale yellow solid

Uses

An impurity arising in the synthesis of Atorvastatin

Synthesis

Firstly, 90mL of methanol and compound L1 were put into a 250mL three-necked bottle. 10g into a 250mL three-necked bottle, slowly add 15% hydrochloric acid solution dropwise, the reaction at 35 ?? for 2h, TLC to monitor the raw material reaction is complete, add saturated NaHCO solution to adjust the pH value of the reaction system to 7; pumping filtration, and 25mL ?? 2 distilled water to wash the filter cake, at 60 ?? blast drying; atorvastatin tert-butyl ester crude product obtained and 30mL The crude atorvastatin tert-butyl ester and 30 mL of tetrahydrofuran were added to a 50 mL single-necked flask and refluxed for 30 min, crystals were frozen and precipitated, extracted and filtered, washed with 5 mL of frozen tetrahydrofuran, and dried at 60 ?? under a blast wind, and the product was weighed as 9.33 g, with a yield of 93.3% and a purity of 99.9%.

Atorvastatin tert-Butyl Ester Preparation Products And Raw materials

Raw materials

Preparation Products

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Atorvastatin tert-Butyl Ester Suppliers

Canada 1 China 133 India 16 United Kingdom 2 United States 11 Global 163

J & K SCIENTIFIC LTD.

Tel: 18210857532; 18210857532
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JIANGXI AIFEIMU TECHNOLOGY CO.,LTD

Tel: 793-33899567 13735087952
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Adamas Reagent, Ltd.

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Chemsky（shanghai）International Co.,Ltd.

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BOC Sciences

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NCE Biomedical Co.,Ltd.

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Shanghai T&W Pharmaceutical Co., Ltd.

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Cato Research Chemicals Inc.

Tel: 020-81960175
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HBCChem, Inc.

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View Lastest Price from Atorvastatin tert-Butyl Ester manufacturers

Career Henan Chemical Co

Product: Atorvastatin tert-Butyl Ester 134395-00-9
Price: US $1.80-3.60/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 88KG
Release date: 2019-09-04

134395-00-9, Atorvastatin tert-Butyl EsterRelated Search:

Atorvastatin IMpurity 8 (1R,3S)-1-(1,3-Benzodioxol-5-yl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylic Acid Methyl Ester Atorvastatin lactone Atorvastatin IMpurity 3 Atorvastatin Impurity 16 3S, 5S enantioMer of Atorvastatin CalciuM Atorvastatin IMpurity 6 Atorvastatin Related Compound A Dihydroxy Diketo Atorvastatin IMpurity Atorvastatin Impurity 15 3S,5R isoMer, or (3S,5R)-7-[3-(phenylcarbaMoyl)-5-(4-fluorophenyl)-2-isopropyl-4-phenyl-1H-pyrrol-1-yl]-3,5-dihydroxyheptanoic acid calciuM salt O-Methyl Atorvastatin Calcium Salt Difluoro Atorvastatin Acetonide tert-Butyl Ester Atorvastatin Epoxy Tetrahydrofuran IMpurity Defluoro Atorvastatin intermediate 1 Atorvastatin intermediate L-2 Diastereomer(3S5R) Atorvastatin intermediate L-2 enantiomer Difluoro Atorvastatin intermediate 1

(4R-cis)-1,1-diMethylethyl-6-[2-[2-(4-fluorophenyl)-5-(1-isopropyl)-3-phenyl-4-[(phenylaMino)carbonyl]-1H-pyrro-1-yl]ethyl]-2,2-diMethyl-1,3-dihydroxy-4-acetate

Atorvastatin t-butyl ester

(3R,5R)-7-[2-(4-Fluorophenyl)-5-isopropyl-3-phenyl-4-phenylcarbamoylpyrrol-1-yl]-3,5-dihydroxyheptanoic acid tert-butyl ester

(R,dR)-2-(4-Fluorophenyl)-,d-dihydroxy-5-(1-Methylethyl)-3-phenyl-4-[(phenylaMino)carbonyl]-1H-pyrrole

(3R,5R)-tert-Butyl 7-(2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl)

(3R,5R)-tert-Butyl 7-(2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbaMoyl)-1H-pyrrol-1-yl)-3,5-dihydroxyheptanoate

Atorvastatin Impurity O reference substance

tert-butyl (3R,5R)-7-[2-(4-fluorophenyl)-3-phenyl-4-(phenylcarbamoyl)-5-propan-2-ylpyrrol-1-yl]-3,5-dihydroxyheptanoate

Atorvastatin Impurity 3（Atorvastatin EP Impurity N）

tert-butyl(3R,5R)-7-(2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4- (phenylcarbamoyl)-1H-pyrrol-1-yl)-3,5-dihydroxyheptanoate

Atorvastatin 3-Fluoro t-Butyl Ester

Atorvastatin impurity 11/Atorvastatin tert-Butyl Ester/(3R,5R)-tert-Butyl 7-(2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl)-3,5-dihydroxyheptanoate

Atorvastatin calcium-8

(3R,5R)-tert-butyl 7-(2-(4-fluorophenyl)

Atorvastatin tert-Butyl Ester (Atorvastatin Impurity 3)

Atorvastatin EP Impurity N

Atorvastatin Calcium Hydrate impurity O

1H-Pyrrole-1-heptanoic acid, 2-(4-fluorophenyl)-β,δ-dihydroxy-5-(1-Methylethyl)-3-phenyl-4-[(phenylaMino)carbonyl]-, 1,1-diMethylethyl ester, (βR,δR)-

Atorvastatin 1

(3R,5R)

-tert-Butyl 7-(2-(4-fluorophenyl)

(3R,5R)-tert-Butyl 7-(2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-

7-[2-(4-Fluoro-phenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)pyrrol-1-yl]-3,5-dihydroxy-heptanoic Acid tert-Butyl Ester

Atorvastatin tert-Butyl Ester

(R,dR)-2-(4-Fluorophenyl)-,d-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrole-1-heptanoic Acid 1,1-Dimethylethyl Ester

Atorvastatin Impurity 21

(βR,δR)-Atorvastatin tert-Butyl Ester (&gt

(βR,δR)-Atorvastatin tert-Butyl Ester

(βR,δR)-Atorvastatin tert-Butyl Ester (>90%)

Atorvastatin Acid tert-Butyl Ester

Atorvastatin Acid t-Butyl EsterQ: What is Atorvastatin Acid t-Butyl Ester Q: What is the CAS Number of Atorvastatin Acid t-Butyl Ester Q: What is the storage condition of Atorvastatin Acid t-Butyl Ester Q: What are the applications of Atorvastatin Acid t-Butyl Ester

ATV imp N ( tertbutyl ester)

Atorvastatin Calcium Impurity N

Atorvastatin Calcium EP Impurity N

Atorvastatin calcium impurity 15

Atorvastatin Impurity 3 (Atorvastatin tert-Butyl Ester)

(βR,δR)-2-(4-Fluorophenyl)-β,δ-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrole-1-heptanoic Acid 1,1-Dimethylethyl Ester

Atorvastatin Acid t-Butyl Ester (3R,5R)-7-[3-(Phenylcarbamoyl)-5-(4-fluorophenyl)-2isopropyl-4- phenyl-1H-pyrrol-1-yl]-3,5-dihydroxyheptanoic acid t-butyl ester

Atorvastatin EP Impurity-N (t-Butyl ester)

Atorvastatin EP Impurity N (Atorvastatin tert-Butyl Ester)

(3R,5R)-tert-Butyl 7-(2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl)-3,5-dihydroxyheptanoate (Atorvastatin calcium Impurity)

(bR,deltaR)-Atorvastatin tert-Butyl Ester (>90%)

Atorvastatin Calcium Impurity O Reference Standard

134395-00-9

C37H43FN2O5

Atorvastatin intermediates

Pfizer compounds

Chiral Reagents

Inhibitors

Intermediates & Fine Chemicals

Pharmaceuticals

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