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Atorvastatin lactone

Product Name
Atorvastatin lactone
CAS No.
125995-03-1
Chemical Name
Atorvastatin lactone
Synonyms
5-(4-Fluorophenyl)-2-(1-methylethyl)-N,4-diphenyl-1-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-1H-pyrrole-3-carboxamide;PD-130694;ATORVASTATIN LACTONE;Atorvastatin USP RC H;Atorvastatin calcium-6;Atorvastatin d-Lactone;Atorvastatin Impurity H;LACTONE IMPURITY(IMP-H);(RS) Atorvastatin Lactone;Atorvastatin lactone ,97%
CBNumber
CB4313438
Molecular Formula
C33H33FN2O4
Formula Weight
540.62
MOL File
125995-03-1.mol
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Atorvastatin lactone Property

Melting point:
103-106°C
alpha 
D +26.05° (c = 1 in chloroform)
Boiling point:
674.8±55.0 °C(Predicted)
Density 
1.24±0.1 g/cm3(Predicted)
storage temp. 
Sealed in dry,2-8°C
solubility 
Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
pka
13.39±0.40(Predicted)
form 
Solid
color 
White to Light Yellow
optical activity
Consistent with structure
Merck 
14,864
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Safety

HS Code 
2933.99.7500
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
PHR1873
Product name
Atorvastatin Related Compound H
Purity
Pharmaceutical Secondary Standard; Certified Reference Material
Packaging
30 mg
Price
$697.3
Updated
2025/07/31
Sigma-Aldrich
Product number
1044582
Product name
Atorvastatin Related Compound H
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
20MG
Price
$1200
Updated
2025/07/31
TCI Chemical
Product number
A3114
Product name
Atorvastatin Lactone
Purity
>95.0%(HPLC)
Packaging
25mg
Price
$122
Updated
2025/07/31
TCI Chemical
Product number
A3114
Product name
Atorvastatin Lactone
Purity
>95.0%(HPLC)
Packaging
100mg
Price
$362
Updated
2025/07/31
Cayman Chemical
Product number
20951
Product name
Atorvastatin lactone
Purity
≥95%
Packaging
1mg
Price
$32
Updated
2024/03/01
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Atorvastatin lactone Chemical Properties,Usage,Production

Chemical Properties

Slightly Yellow Solid

Uses

Atorvastatin intermediate as inhibitor of MAP kinase and/or HMG-CoA reductase for the treatment of inflammation

Uses

Atorvastatin Lactone (Atorvastatin EP Impurity H) is an intermediate of Atorvastatin, a inhibitor of MAP kinase and/or HMG-CoA reductase for the treatment of inflammation.

Synthesis

134523-03-8

125995-03-1

Calcium salt of (3R,5R)-7-[2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl]-3,5-dihydroxyheptanoic acid (500 mg, 0.413 mmol) was used as a raw material, which was suspended in water (8 mL), EtOAc (4 mL) was added, and the mixture was cooled in an ice bath (4°C). An aqueous 0.2 M HCl solution (4.55 mL, 0.910 mmol) was added slowly and dropwise under vigorous stirring until a clarified solution was formed. The reaction mixture was gradually warmed to room temperature, followed by separation of the organic and aqueous layers. The aqueous layer was extracted with EtOAc (3 x 5 mL), the combined organic layers were washed with brine (5 mL), dried over anhydrous Na2SO4, filtered and concentrated under reduced pressure. The resulting foam (469 mg) was dissolved in toluene (20 mL) and the mixture was heated to 0°C and refluxed for 2.5 h under a Dean-Stark apparatus. Upon completion of the reaction, the mixture was cooled to room temperature and concentrated under reduced pressure. Purification by fast column chromatography (eluent: heptane/EtOAc, gradient from 1:3 to 1:5) afforded the target product 5-(4-fluorophenyl)-2-(1-methylethyl)-N,4-diphenyl-1-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-1H-pyrrole-3-carboxamide (394 mg. (white foamy substance). NMR hydrogen spectrum (400 MHz, CDCl3) δ 7.24-7.10 (m, 9H), 7.09-6.96 (m, 5H), 6.92-6.82 (br s, 1H), 4.57-4.47 (m, 1H), 4.34-4.27 (m, 1H), 4.27-4.16 (m, 1H), 4.09-3.97 (m , 1H), 3.62-3.47 (m, 1H), 2.66 (ABdd, J = 17.7, 4.8 Hz, 1H), 2.55 (ABddd, J = 17.7, 3.4, 1.5 Hz, 1H), 2.11 (d, J = 2.9 Hz, 1H), 1.95-1.82 (m, 1H), 1.81-1.67 (m, 2H) , 1.63-1.57 (m, 1H), 1.56-1.45 (m, 6H).

References

[1] Patent: WO2017/137469, 2017, A1. Location in patent: Page/Page column 62
[2] Patent: CN105085497, 2017, B. Location in patent: Paragraph 0115; 0116; 0117

Atorvastatin lactone Preparation Products And Raw materials

Raw materials

Preparation Products

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Atorvastatin lactone Suppliers

Americas 1 Canada 3 China 177 Europe 1 India 20 Japan 1 United Kingdom 2 United States 17 Global 222
J & K SCIENTIFIC LTD.
Tel
18210857532; 18210857532
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86-10-82849933
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jkinfo@jkchemical.com
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China
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JIANGXI AIFEIMU TECHNOLOGY CO.,LTD
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793-33899567 13735087952
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+86-570-6259526
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sales@afmpharm.com
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China
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Adamas Reagent, Ltd.
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400-6009262 16621234537
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021-64823266
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chenyj@titansci.com
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China
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Chemsky（shanghai）International Co.,Ltd.
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021-50135380
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shchemsky@sina.com
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China
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Daicel Chiral Technologies (China)CO.,LTD
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021-50460086-9 15921403865
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+86-21-50462321
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China
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BOC Sciences
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1-631-485-4226; 16314854226
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info@bocsci.com
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United States
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12952
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S.Z. PhyStandard Bio-Tech. Co., Ltd.
Tel
0755-4000505016 13380397412
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0755 28094224
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3001272453@qq.com
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China
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TOKYO CHEMICAL INDUSTRY CO., LTD.
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03-36680489
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03-3668-0520
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Sales-JP@TCIchemicals.com
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Japan
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TCI Europe
Tel
320-37350700
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+32 (0)37350701
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sales@tcieurope.eu
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Europe
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TCI AMERICA
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800-4238616
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+1-888-520-1075 / +1-503-283-1987
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sales@tciamerica.com
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Americas
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View Lastest Price from Atorvastatin lactone manufacturers

Guangzhou PI PI BIOTECH INC
Product
Atorvastatin Impurity H(EP) 125995-03-1
Price
US $0.00-0.00/mg
Min. Order
10mg
Purity
90%+
Supply Ability
10g
Release date
2020-06-04
Guangzhou PI PI BIOTECH INC
Product
Atorvastatin Impurity E Intermediate
Price
US $0.00-0.00/mg
Min. Order
10mg
Purity
90%+
Supply Ability
10g
Release date
2020-06-04
Hangzhou ICH Biofarm Co., Ltd
Product
5-(4-fluorophenyl)-2-(1-methyl-ethyl)-N,4-diphenyl-1-[2-[(2R,4R)-tetrahydro- hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-1H-pyrrole-3-carboxamide 125995-03-1
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
500
Release date
2023-07-06

125995-03-1, Atorvastatin lactoneRelated Search:

Phenyl salicylate Diphenyl ether Polyvinylpyrrolidone Atorvastatin calcium Isopropyl alcohol N-Methyl-2-pyrrolidone Pyrrolidine PHENYL VALERATE ISOPROPYL LAURATE N-Vinyl-2-pyrrolidone TRIOXSALEN Atorvastatin tert-Butyl (4R,6R)-2-[[[6-(2-4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)pyrrol-1-yl]ethyl]-2,2-dimethyl-1,3-dioxan-4-yl]acetate Defluoro Atorvastatin Atorvastatin Impurity 40 PHENYL RESIN Phenylacetic acid 3S,5R isoMer, or (3S,5R)-7-[3-(phenylcarbaMoyl)-5-(4-fluorophenyl)-2-isopropyl-4-phenyl-1H-pyrrol-1-yl]-3,5-dihydroxyheptanoic acid calciuM salt

  • 1-[2-[[(2R)-Tetrahydro-4β-hydroxy-6-oxo-2H-pyran]-2α-yl]ethyl]-5-(4-fluorophenyl)-2-isopropyl-4,N-diphenyl-1H-pyrrole-3-carboxamide
  • Atorvastatin EPIMp H (USP RCH)
  • Atorvastatin EP IMpurity H
  • Atorvastatin Related Compound H (20 mg) (5-(4-Fluorophenyl)-1-{2-[(2R, 4R)-4-hydroxy-6-oxotetrahydro-2H-pyran-2-yl]ethyl}-2-isopropyl-N,4-diphenyl-1H-pyrrole-3-carboxamide)
  • Diepoxide Atorvastatin Lactone Diepoxide
  • Atorvastatin Calcium Impurity D
  • Atorvastatin Impurity H
  • (RS) Atorvastatin Lactone
  • ATORVASTATIN LACTONE
  • Atorvastatin lactone (EP impurity H)
  • (4R,6R)-6-[2-[2-(4-flfluorophenyl)-5-(1-methylethyl)-3- phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl]ethyl]-4- hydroxytetrahydro-2H-pyran-2-one
  • Atorvastatin Impurity H(EP)
  • Atorvastatin USP RC H
  • Atorvastatin EP Impurity H (USP RC H)Ator. Lacton
  • Atorvastatin impurity 9/Atorvastatin EP Impurity H/Atorvastatin Lactone/5-(4-fluorophenyl)-2-(1-methyl-ethyl)-N,4-diphenyl-1-[2-[(2R,4R)-tetrahydro- hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-1H-pyrrole-3-carboxamide
  • Atorvastatin calcium-6
  • 5-(4-fluorophenyl)-1-(2-((2R,4R)
  • Atorvastatin Calcium Hydrate impurity H
  • Atorvastatin EP Impurity H (Atorvastatin Lactone)
  • 5-(4-Fluorophenyl)-2-(1-methylethyl)-N,4-diphenyl-1-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-1H-pyrrole-3-carboxamide
  • Atorvastatin d-Lactone
  • (4R,6R)-6-{2-[2-(4-Fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)pyrrol-1-yl]ethyl}-4-hydroxytetrahydro-2H-pyran-2-one
  • 5-(4-fluorophenyl)-1-[2-[(2R,4R)-4-hydroxy-6-oxooxan-2-yl]ethyl]-N,4-diphenyl-2-propan-2-ylpyrrole-3-carboxamide
  • (3R,5R)-7-[2-(4-Fluorophenyl)-5-isopropyl-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrole-1-yl]-3,5-dihydroxyheptanoic acid 1,5-lactone
  • (4R,6R)-6-[2-[2-(4-Fluorophenyl)-5-
  • Atorvastatin Lactone (Atorvastatin EP Impurity H)
  • PD-130694
  • 1H-Pyrrole-3-carboxamide, 5-(4-fluorophenyl)-2-(1-methylethyl)-N,4-diphenyl-1-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-
  • Atorvastatin lactone ( imp H)
  • USP Atorvastatin Related Compound H
  • Atorvastatin EP Impurity H/ Atorvastatin Related Compound H (Atorvastatin Lactone)
  • Atorvastatin D5 LactoneQ: What is Atorvastatin D5 Lactone Q: What is the CAS Number of Atorvastatin D5 Lactone Q: What is the storage condition of Atorvastatin D5 Lactone Q: What are the applications of Atorvastatin D5 Lactone
  • Atorvastatin LactoneQ: What is Atorvastatin Lactone Q: What is the CAS Number of Atorvastatin Lactone Q: What is the storage condition of Atorvastatin Lactone Q: What are the applications of Atorvastatin Lactone
  • Atorvastatin Related Compound H (1044582)Q: What is Atorvastatin Related Compound H (1044582) Q: What is the CAS Number of Atorvastatin Related Compound H (1044582)
  • AtorvastatinEPImpurityH-d5
  • Atorvastatin USP Related Compound H
  • Atorvastatin Calcium Trihydrate EP Impurity H
  • Atorvastatin Calcium Trihydrate Impurity H
  • Atorvastatin calcium impurity H
  • 5-(4-fluorophenyl)-1-{2-[(2R,4R)-4-hydroxy-6-oxooxan-2-yl]ethyl}-N,4-diphenyl-2-(propan-2-yl)-1H-pyrrole-3-carboxamide
  • Atorvastatin EP Impurity H (Atorvastatin USP Related Compound H, Atorvastatin Lactone)
  • LACTONE IMPURITY(IMP-H)
  • (4R,6R)-6-[2-[2-(4-Fluorophenyl)-5-(1-methylethyl)-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl]ethyl
  • Atorvastatin lactone, 10 mM in DMSO
  • Atorvastatin lactone ,97%
  • (4R,6R)-6-[2-[2-(4-Fluorophenyl)-5-(1-methylethyl)-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl]ethyl]-4-hydroxytetrahydro-2H-pyran-2-one (Atorvastatin Lactone)
  • 125995-03-1
  • 12599-03-1
  • C33H33FN2O4
  • Inhibitors
  • Intermediates & Fine Chemicals
  • Metabolites & Impurities
  • Pharmaceuticals