ChemicalBook > CAS DataBase List > 1-(3,4-dichlorophenyl)-3-azabicyclo[3.1.0]hexane

1-(3,4-dichlorophenyl)-3-azabicyclo[3.1.0]hexane

Product Name
1-(3,4-dichlorophenyl)-3-azabicyclo[3.1.0]hexane
CAS No.
66504-40-3
Chemical Name
1-(3,4-dichlorophenyl)-3-azabicyclo[3.1.0]hexane
Synonyms
DOV-216;DOV216303;303 Free Base;DOV-216,303 (Free Base);DOV-216,303 Free Base, 10 mM in DMSO;1-(3,4-dichlorophenyl)-3-azabicyclo[3.1.0]hexane;3-Azabicyclo[3.1.0]hexane, 1-(3,4-dichlorophenyl)-;1-(3,4-dichlorophenyl)-3-azabicyclo(3.1.0)hexane 11H11Cl2N;1-(3,4-Dichloro-phenyl)-3-aza-bicyclo[3.1.0]hexane - [D13223];inhibit,SLC6A4,Serotonin Transporter,DOV 216,303 Free Base,5-HTT,DAT,DOV-216,303,SERT,Dopamine Transporter,SLC6A3,Inhibitor,DOV216,303 Free Base
CBNumber
CB32561096
Molecular Formula
C11H11Cl2N
Formula Weight
228.12
MOL File
66504-40-3.mol
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1-(3,4-dichlorophenyl)-3-azabicyclo[3.1.0]hexane Property

Boiling point:
324.4±37.0 °C(Predicted)
Density 
1.371
storage temp. 
Store at -20°C
solubility 
DMSO : ≥ 125 mg/mL (547.96 mM);Water : < 0.1 mg/mL (insoluble)
pka
10.45±0.40(Predicted)
form 
Oil
color 
Colorless to light yellow
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

H319Causes serious eye irritation

H331Toxic if inhaled

H401Toxic to aquatic life

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P311Call a POISON CENTER or doctor/physician.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P337+P313IF eye irritation persists: Get medical advice/attention.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC
Product number
D650400
Product name
1-(3,4-Dichlorophenyl)-3-azabicyclo[3.1.0]hexane
Packaging
5mg
Price
$45
Updated
2021/12/16
Synthonix
Product number
D13223
Product name
1-(3,4-Dichloro-phenyl)-3-aza-bicyclo[3.1.0]hexane
Purity
95+%
Packaging
250mg
Price
$280
Updated
2021/12/16
ChemScene
Product number
CS-0052898
Product name
DOV-216,303FreeBase
Purity
98.47%
Packaging
5mg
Price
$350
Updated
2021/12/16
Activate Scientific
Product number
AS58370
Product name
1-(3,4-Dichlorophenyl)-3-azabicyclo[3.1.0]hexane
Purity
95+%
Packaging
250mg
Price
$390
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
HCH0419896
Product name
1-(3,4-DICHLORO-PHENYL)-3-AZA-BICYCLO[3.1.0]HEXANE
Purity
95.00%
Packaging
5MG
Price
$504.21
Updated
2021/12/16
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1-(3,4-dichlorophenyl)-3-azabicyclo[3.1.0]hexane Chemical Properties,Usage,Production

Uses

DOV-216,303 (Free Base) is a potent triple serotonin, norepinephrine, and dopamine reuptake inhibitor, with IC50 values of 14 nM, 20 nM and 78 nM for hSERT, hNET and hDAT, respectively[1]. Has antidepressant-like effects and increases monoamine release in the prefrontal cortex of olfactory bulbectomized (OBX) rats[2].

in vivo

Acute treatment of DOV-216,303 (20 mg/kg, i.p.) significantly increases dopamine, norepinephrine and serotonin levels in both OBX and Sham animals[2].
Chronic treatment with DOV 216,303 (20 mg/kg, i.p., for 17 days) increases extracellular concentrations of dopamine, norepinephrine and serotonin in the medial prefrontal cortex of both OBX and Sham animals and significantly increases extracellular baseline serotonin concentrations[2].

Animal Model:Male Sprague Dawley rats weighing between 290 and 350 g at time of OBX or Sham surgery[2].
Dosage:20 mg/kg.
Administration:I.P. daily for 17days.
Result:Increased extracellular concentrations of dopamine, norepinephrine and serotonin in the medial prefrontal cortex of both OBX and Sham animals and significantly increased extracellular baseline serotonin concentrations.
Animal Model:Male Sprague Dawley rats weighing between 290 and 350 g at time of OBX or Sham surgery[2].
Dosage:20 mg/kg.
Administration:I.P. once.
Result:Significant increases in dopamine, norepinephrine and serotonin levels were measured in both OBX and Sham animals.

References

[1] Shao L, et al. Discovery of N-methyl-1-(1-phenylcyclohexyl)methanamine, a novel triple serotonin, norepinephrine, and dopamine reuptake inhibitor. Bioorg Med Chem Lett. 2011 Mar 1;21(5):1438-41. DOI:10.1016/j.bmcl.2011.01.016
[2] Prins J, et al. The putative antidepressant DOV 216,303, a triple reuptake inhibitor, increases monoamine release in the prefrontal cortex of olfactory bulbectomized rats. Eur J Pharmacol. 2010 May 10;633(1-3):55-61. DOI:10.1095/biolreprod44.3.561

1-(3,4-dichlorophenyl)-3-azabicyclo[3.1.0]hexane Preparation Products And Raw materials

Raw materials

Preparation Products

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1-(3,4-dichlorophenyl)-3-azabicyclo[3.1.0]hexane Suppliers

China 27 India 1 United States 6 Global 34
PharmaBlock Sciences (Nanjing),Inc.
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66504-40-3, 1-(3,4-dichlorophenyl)-3-azabicyclo[3.1.0]hexaneRelated Search:

CHLOROPHENYLSILANE Phenylsilane Phenyltrichlorosilane

  • 3-Azabicyclo[3.1.0]hexane, 1-(3,4-dichlorophenyl)-
  • DOV-216,303 (Free Base)
  • 1-(3,4-dichlorophenyl)-3-azabicyclo(3.1.0)hexane 11H11Cl2N
  • 1-(3,4-dichlorophenyl)-3-azabicyclo[3.1.0]hexane
  • DOV216303
  • 303 Free Base
  • DOV-216
  • inhibit,SLC6A4,Serotonin Transporter,DOV 216,303 Free Base,5-HTT,DAT,DOV-216,303,SERT,Dopamine Transporter,SLC6A3,Inhibitor,DOV216,303 Free Base
  • DOV-216,303 Free Base, 10 mM in DMSO
  • 1-(3,4-Dichloro-phenyl)-3-aza-bicyclo[3.1.0]hexane - [D13223]
  • 66504-40-3
  • 11H11Cl2N