Glutaminase C-IN-1
- Product Name
- Glutaminase C-IN-1
- CAS No.
- 311795-38-7
- Chemical Name
- Glutaminase C-IN-1
- Synonyms
- CS-2083;GLS-IN-968;Compound 968;GAC Inhibitor 968;Glutaminase C-IN-1;Glutaminase C-IN-1 (968);Glutaminase C inhibitor 1;glutaminase inhibitor 968;Glutaminase Inhibitor Compound 968;Glutaminase Inhibitor 968 >=98% (HPLC)
- CBNumber
- CB32561506
- Molecular Formula
- C27H27BrN2O
- Formula Weight
- 475.42
- MOL File
- 311795-38-7.mol
Glutaminase C-IN-1 Property
- Boiling point:
- 623.2±55.0 °C(Predicted)
- Density
- 1.39±0.1 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- Soluble in DMSO (up to 11 mg/ml) or in Ethanol (up to 1 mg/ml with warming)
- form
- powder
- pka
- 4.09±0.42(Predicted)
- color
- white to beige
- Stability:
- Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
N-Bromosuccinimide Price
- Product number
- SML1327
- Product name
- Glutaminase Inhibitor 968
- Purity
- ≥98% (HPLC)
- Packaging
- 5MG
- Price
- $115
- Updated
- 2023/06/20
- Product number
- SML1327
- Product name
- Glutaminase Inhibitor 968
- Purity
- ≥98% (HPLC)
- Packaging
- 25MG
- Price
- $451
- Updated
- 2023/06/20
- Product number
- 17199
- Product name
- Glutaminase Inhibitor Compound 968
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $32
- Updated
- 2024/03/01
- Product number
- 17199
- Product name
- Glutaminase Inhibitor Compound 968
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $70
- Updated
- 2024/03/01
- Product number
- 17199
- Product name
- Glutaminase Inhibitor Compound 968
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $122
- Updated
- 2024/03/01
Glutaminase C-IN-1 Chemical Properties,Usage,Production
Description
GAC Inhibitor 968 (311795-38-7) is an allosteric inhibitor of glutaminase C (GAC).1 Inhibition of GAC blocks oncogenic transformation induced by Rho GTPases in fibroblasts and B lymphoma cells with no effect on normal cells.2 Inhibits liver-type glutaminase GLS2 and suppresses breast tumor growth in vivo.3,4 Reverses acquired erlotinib resistance in non-small cell lung cancer.5
Uses
Glutaminase inhibitor 968 has been used to study the role of glutamine metabolism in macrophage activation.
Definition
ChEBI: 5-[3-bromo-4-(dimethylamino)phenyl]-2,2-dimethyl-2,3,5,6-tetrahydrobenzo[a]phenanthridin-4(1H)-one is a partially hydrogenated benzophenanthridine carrying an oxo group at C-4, geminal methyl groups at C-2 and a 3-bromo-4-(dimethylamino)phenyl group at C-5. It has a role as an EC 3.5.1.2 (glutaminase) inhibitor.
General Description
Glutaminase Inhibitor 968 belongs to the benzophenanthridinone family.
Biochem/physiol Actions
Glutaminase Inhibitor 968 is an allosteric inihibitor of the mitochondrial enzyme glutaminase C (GAC), which is overexpressed in a number of cancer cell lines. Glutaminase Inhibitor 968 shows 21% inhibition at 10 μM, 94% at 25 μM. Glutaminase Inhibitor 968 blocked human cancer cell proliferation in culture, and in inhibited tumor formation in mouse xenograft models.
storage
Store at -20°C
References
Stainecker et al. (2015), Mechanism by which a recently discovered allosteric inhibitor blocks glutamine metabolism in transformed cells; Proc. Natl. Acad. Sci. USA, 112 394 Wang et al. (2010), Targeting mitochondrial glutaminase activity inhibits oncogenic transformation; Cancer Cell, 18 207 Katt et al. (2012), Dibenzophenanthridines as inhibitors of glutaminase C and cancer cell proliferation; Cancer Ther., 11 1269 Lukey et al. (2019), Liver-Type Glutaminase GLS2 Is a Druggable Metabolic Node in Luminal-Subtype Breast Cancer; Cell Reports, 29 76 Xie et al. (2016), Inhibition of mitochondrial glutaminase activity reverses acquired erlotinib resistance in non-small cell lung cancer; Oncotarget, 7 610
Glutaminase C-IN-1 Preparation Products And Raw materials
Raw materials
Preparation Products
Glutaminase C-IN-1 Suppliers
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- 0757-86329057 18501085097
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View Lastest Price from Glutaminase C-IN-1 manufacturers
- Product
- Glutaminase C-IN-1 311795-38-7
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- Customized
- Release date
- 2019-09-04