METHYL 2-FLUORO-5-NITROBENZOATE
- Product Name
- METHYL 2-FLUORO-5-NITROBENZOATE
- CAS No.
- 2965-22-2
- Chemical Name
- METHYL 2-FLUORO-5-NITROBENZOATE
- Synonyms
- RARECHEM AL BF 0280;METHYL 2-FLUORO-5-NITROBENZOATE;Methyl2-fluoro-5-nitrobenzoate,98%;4-Fluoro-3-(Methoxycarbonyl)nitrobenzene;5-nitro-2-fluorobenzoic acid methyl ester;methyl 2-fluoro-5-nitrobenzenecarboxylate;Benzoic acid, 2-fluoro-5-nitro-, methyl ester
- CBNumber
- CB3256172
- Molecular Formula
- C8H6FNO4
- Formula Weight
- 199.14
- MOL File
- 2965-22-2.mol
METHYL 2-FLUORO-5-NITROBENZOATE Property
- Melting point:
- 49-51℃
- Boiling point:
- 303℃
- Density
- 1.388
- Flash point:
- 137℃
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- soluble in Methanol
- form
- Solid
- color
- White to Yellow to Green
Safety
- HazardClass
- IRRITANT
- HS Code
- 2916399090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- M3115
- Product name
- Methyl 2-Fluoro-5-nitrobenzoate
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $91
- Updated
- 2025/07/31
- Product number
- M3115
- Product name
- Methyl 2-Fluoro-5-nitrobenzoate
- Purity
- >98.0%(GC)
- Packaging
- 25g
- Price
- $366
- Updated
- 2025/07/31
- Product number
- M305570
- Product name
- Methyl 2-Fluoro-5-nitrobenzoate
- Packaging
- 250mg
- Price
- $55
- Updated
- 2021/12/16
- Product number
- 047966
- Product name
- Methyl 2-fluoro-5-nitrobenzenecarboxylate
- Purity
- 95+%
- Packaging
- 5g
- Price
- $19
- Updated
- 2021/12/16
- Product number
- 047966
- Product name
- Methyl 2-fluoro-5-nitrobenzenecarboxylate
- Purity
- 95+%
- Packaging
- 100g
- Price
- $236
- Updated
- 2021/12/16
METHYL 2-FLUORO-5-NITROBENZOATE Chemical Properties,Usage,Production
Synthesis
67-56-1
7304-32-7
2965-22-2
General procedure for the synthesis of methyl 2-fluoro-5-nitrobenzoate from methanol and 2-fluoro-5-nitrobenzoic acid: 1. dissolve 2-fluoro-5-nitrobenzoic acid (3.7 g, 20.0 mmol) in methanol (100 mL) at 0 °C. 2. Slowly add thionyl chloride (5.3 mL, 60.0 mmol) dropwise. 3. The reaction mixture was heated to reflux for 24 hours. 4. Upon completion of the reaction, the solvent was removed by vacuum concentration. 5. 5. The residue was dissolved in ethyl acetate and washed several times with 1.0 M NaOH solution. 6. The organic phase was dried with anhydrous sodium sulfate and the solvent was evaporated in vacuum to give the intermediate methyl 2-fluoro-5-nitrobenzoate (Intermediate 37) as a yellow oil, which crystallized into light yellow needle crystals after standing. Yield: 90%; Melting point: 47-49°C; 1H NMR (300MHz, CDCl3) δ= 4.01 (s, 3H, OCH3), 7.35 (t, 1H, H3,3JH3.H4 = 3JH3.F = 9.2Hz), 8.44 (dt, 1H, 3JH4-H3 = 9.2Hz, 4JH4.F = 4JH4-H6 = 3.5Hz), 8.87 (dd, 1H. 4JH6-F = 5.9 Hz, 4JH6-H4 = 2.7 Hz); 13C NMR (75 MHz, CDCl3): δ= 47.7 (OCH3), 113.2 (d, C3,2JC-F = 25.1 Hz), 114.5 (d, C1, 2JC-F = 12.0 Hz), 122.9 (d, C6,3JC-F = 3.3 Hz), 124.3 (d, C4,3JC-F = 10.9 Hz ), 138.6 (C5), 157.4 (d, COOCH3,3JC-F = 3.8 Hz), 159.8 (d, C2,1JC-F = 269.0 Hz).
References
[1] Patent: WO2012/85003, 2012, A1. Location in patent: Page/Page column 83-84
[2] Journal of Medicinal Chemistry, 2014, vol. 57, # 11, p. 4640 - 4660
[3] Patent: EP3192791, 2017, A1. Location in patent: Paragraph 0467
[4] Patent: WO2009/80836, 2009, A2. Location in patent: Page/Page column 70
[5] Patent: WO2004/92124, 2004, A2. Location in patent: Page 77
METHYL 2-FLUORO-5-NITROBENZOATE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from METHYL 2-FLUORO-5-NITROBENZOATE manufacturers
- Product
- METHYL 2-FLUORO-5-NITROBENZOATE 2965-22-2
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 200kg
- Release date
- 2018-12-25
- Product
- METHYL 2-FLUORO-5-NITROBENZOATE 2965-22-2
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 200kg
- Release date
- 2018-12-25
- Product
- METHYL 2-FLUORO-5-NITROBENZOATE 2965-22-2
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 200kg
- Release date
- 2018-12-25