Xylometazoline hydrochloride
- Product Name
- Xylometazoline hydrochloride
- CAS No.
- 1218-35-5
- Chemical Name
- Xylometazoline hydrochloride
- Synonyms
- XYLOMETAZOLINE HCL;Olynth;Novorin;XyMelin;Therapin;Brizolin;Galazolin;Neo-Rinoleina;Neo-Synephrine II;XYLONETAZOLINEHCL
- CBNumber
- CB3257614
- Molecular Formula
- C16H25ClN2
- Formula Weight
- 280.84
- MOL File
- 1218-35-5.mol
Xylometazoline hydrochloride Property
- Melting point:
- 131-133 C
- storage temp.
- 2-8°C
- solubility
- Freely soluble in water, in ethanol (96 per cent) and in methanol.
- form
- Solid
- color
- Crystals
- Merck
- 14,10086
- CAS DataBase Reference
- 1218-35-5(CAS DataBase Reference)
- EPA Substance Registry System
- 1H-Imidazole, 2-[[4-(1,1-dimethylethyl)-2,6-dimethylphenyl]methyl]-4,5-dihydro-, monohydrochloride (1218-35-5)
Safety
- Hazard Codes
- Xn,Xi
- Risk Statements
- 22-36/37/38
- Safety Statements
- 36-26
- RIDADR
- UN 2811 6.1/PG 3
- WGK Germany
- 3
- RTECS
- NJ2390000
- HazardClass
- 6.1
- PackingGroup
- III
- HS Code
- 29332900
- Toxicity
- LD50 orl-rat: 230 mg/kg KSRNAM 5,555,71
N-Bromosuccinimide Price
- Product number
- 1721002
- Product name
- Xylometazoline hydrochloride
- Purity
- United States Pharmacopeia (USP) Reference Standard
- Packaging
- 250mg
- Price
- $436
- Updated
- 2024/03/01
- Product number
- BP353
- Product name
- Xylometazoline hydrochloride
- Purity
- British Pharmacopoeia (BP) Reference Standard
- Packaging
- 100MG
- Price
- $221
- Updated
- 2023/06/20
- Product number
- 07297
- Product name
- Xylometazoline hydrochloride
- Purity
- analytical standard
- Packaging
- 100mg
- Price
- $108
- Updated
- 2022/05/15
- Product number
- X0063
- Product name
- Xylometazoline Hydrochloride
- Purity
- >98.0%(HPLC)(N)
- Packaging
- 1g
- Price
- $44
- Updated
- 2024/03/01
- Product number
- X0063
- Product name
- Xylometazoline Hydrochloride
- Purity
- >98.0%(HPLC)(N)
- Packaging
- 5g
- Price
- $112
- Updated
- 2024/03/01
Xylometazoline hydrochloride Chemical Properties,Usage,Production
Chemical Properties
Xylometazoline hydrochloride is white or almost white, crystalline powder.
Originator
Otrivin,Geigy,US,1959
Uses
anthelmintic
Uses
Xylometazoline hydrochloride may be used as a reference standard in determining the xylometazoline hydrochloride content in samples of nasal drops using high performance liquid chromatography (HPLC).
Uses
Xylometazoline hydrochloride is used as a nasal decongestant.
Manufacturing Process
62 grams of para-tertiany-butyl-ortho,ortho'-dimethyl-phenyl-acetonitrile
[obtainable, for example, by the method of Buu-Hoi and P. Cagniant, Bulletin
de la Societe Chimique de France, volume 9, page 891 (1942)], 20.6 grams of
ethylenediamine of 96% purity and 1.55 cc of carbon disulfide are heated
together in a distillation flask with the exclusion of moisture for 48 hours on a
boiling water bath. Ammonia is evolved. Upon cooling the reaction product
solidifies and is then dissolved in benzene, the solution is filtered while hot
with the addition of animal charcoal and petroleum ether is added. The
mixture is filtered to remove the impurities that are first precipitated and by
the further addition of petroleum ether 2-(para-tertiary-butyl-ortho,ortho'-
dimethyl-phenyl-methyl)-imidazoline is caused to crystallize out.
The product melts at 131° to 133°C after being recrystallized from a mixture of benzene and petroleum ether. It can be converted into its hydrochloride as
follows:
189 grams of 2-(para-tertiary-butyl-ortho,ortho'-dimethyl-phenyl-methyl)-
imidazoline are dissolved in 400 cc of absolute ethanol, the solution is
rendered acid by the addition of 104 cc of an ethanolic solution of hydrochloric
acid of 30% strength, the mixture is filtered with the addition of animal
charcoal, and dry ethyl acetate and absolute ether are added until
crystallization sets in. After cooling the mixture, the salt is filtered off with
suction and crystallized several times from absolute ethanol with the use of
animal charcoal and the addition of dry mixture of ethyl acetate and ether.
The hydrochloride so obtained melts at 327° to 329°C (with decomposition).
brand name
Neo-Synephrine II (Sterling Winthrop); Otrivin Hydrochloride (Ciba-Geigy).
Therapeutic Function
Adrenergic (vasopressor)
General Description
Xylometazoline hydrochloride is a derivative of imidazole, and a representative of the class of α1 agonists. It is commonly used in nasal decongestants, which works on the principle of constricting the blood vessels in the mucous membranes.
Biochem/physiol Actions
α-adrenoceptor agonist; imidazoline binding site ligand.
Safety Profile
Poison by ingestion, subcutaneous, intravenous, and intraperitoneal routes. When heated to decomposition it emits toxic fumes of NOx and HCl.
Xylometazoline hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
Xylometazoline hydrochloride Suppliers
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- Europe
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View Lastest Price from Xylometazoline hydrochloride manufacturers
- Product
- Xylometazoline hydrochloride 1218-35-5
- Price
- US $0.00-0.00/KG
- Min. Order
- 100g
- Purity
- 99.0%-101%
- Supply Ability
- 100 KGS
- Release date
- 2021-06-08
- Product
- Xylometazoline Hydrochloride 1218-35-5
- Price
- US $0.00/g
- Min. Order
- 1g
- Purity
- More Than 99%
- Supply Ability
- 100kg/Month
- Release date
- 2024-11-13
- Product
- Xylometazoline hydrochloride 1218-35-5
- Price
- US $0.00/g
- Min. Order
- 5g
- Purity
- 98%
- Supply Ability
- 500kg
- Release date
- 2023-02-08