Xylometazoline hydrochloride

Product Name: Xylometazoline hydrochloride
CAS No.: 1218-35-5
Chemical Name: Xylometazoline hydrochloride
Synonyms: XYLOMETAZOLINE HCL;Olynth;Novorin;XyMelin;Therapin;Brizolin;Galazolin;Neo-Rinoleina;Neo-Synephrine II;XYLONETAZOLINEHCL
CBNumber: CB3257614
Molecular Formula: C16H25ClN2
Formula Weight: 280.84
MOL File: 1218-35-5.mol

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Xylometazoline hydrochloride Property

Melting point:: 131-133 C
storage temp.: 2-8°C
solubility: Freely soluble in water, in ethanol (96 per cent) and in methanol.
form: Solid
color: Crystals
Merck: 14,10086
CAS DataBase Reference: 1218-35-5(CAS DataBase Reference)
EPA Substance Registry System: 1H-Imidazole, 2-[[4-(1,1-dimethylethyl)-2,6-dimethylphenyl]methyl]-4,5-dihydro-, monohydrochloride (1218-35-5)

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Safety

Hazard Codes: Xn,Xi
Risk Statements: 22-36/37/38
Safety Statements: 36-26
RIDADR: UN 2811 6.1/PG 3
WGK Germany: 3
RTECS: NJ2390000
HazardClass: 6.1
PackingGroup: III
HS Code: 29332900
Toxicity: LD50 orl-rat: 230 mg/kg KSRNAM 5,555,71

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Danger
Hazard statements: H301Toxic if swalloed
Precautionary statements: P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 1721002
Product name: Xylometazoline hydrochloride
Purity: United States Pharmacopeia (USP) Reference Standard
Packaging: 250mg
Price: $436
Updated: 2024/03/01

Sigma-Aldrich

Product number: BP353
Product name: Xylometazoline hydrochloride
Purity: British Pharmacopoeia (BP) Reference Standard
Packaging: 100MG
Price: $221
Updated: 2023/06/20

Sigma-Aldrich

Product number: 07297
Product name: Xylometazoline hydrochloride
Purity: analytical standard
Packaging: 100mg
Price: $108
Updated: 2022/05/15

TCI Chemical

Product number: X0063
Product name: Xylometazoline Hydrochloride
Purity: >98.0%(HPLC)(N)
Packaging: 1g
Price: $44
Updated: 2024/03/01

TCI Chemical

Product number: X0063
Product name: Xylometazoline Hydrochloride
Purity: >98.0%(HPLC)(N)
Packaging: 5g
Price: $112
Updated: 2024/03/01

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Xylometazoline hydrochloride Chemical Properties,Usage,Production

Chemical Properties

Xylometazoline hydrochloride is white or almost white, crystalline powder.

Originator

Otrivin,Geigy,US,1959

Uses

anthelmintic

Uses

Xylometazoline hydrochloride may be used as a reference standard in determining the xylometazoline hydrochloride content in samples of nasal drops using high performance liquid chromatography (HPLC).

Uses

Xylometazoline hydrochloride is used as a nasal decongestant.

Manufacturing Process

62 grams of para-tertiany-butyl-ortho,ortho'-dimethyl-phenyl-acetonitrile [obtainable, for example, by the method of Buu-Hoi and P. Cagniant, Bulletin de la Societe Chimique de France, volume 9, page 891 (1942)], 20.6 grams of ethylenediamine of 96% purity and 1.55 cc of carbon disulfide are heated together in a distillation flask with the exclusion of moisture for 48 hours on a boiling water bath. Ammonia is evolved. Upon cooling the reaction product solidifies and is then dissolved in benzene, the solution is filtered while hot with the addition of animal charcoal and petroleum ether is added. The mixture is filtered to remove the impurities that are first precipitated and by the further addition of petroleum ether 2-(para-tertiary-butyl-ortho,ortho'- dimethyl-phenyl-methyl)-imidazoline is caused to crystallize out.
The product melts at 131° to 133°C after being recrystallized from a mixture of benzene and petroleum ether. It can be converted into its hydrochloride as follows:
189 grams of 2-(para-tertiary-butyl-ortho,ortho'-dimethyl-phenyl-methyl)- imidazoline are dissolved in 400 cc of absolute ethanol, the solution is rendered acid by the addition of 104 cc of an ethanolic solution of hydrochloric acid of 30% strength, the mixture is filtered with the addition of animal charcoal, and dry ethyl acetate and absolute ether are added until crystallization sets in. After cooling the mixture, the salt is filtered off with suction and crystallized several times from absolute ethanol with the use of animal charcoal and the addition of dry mixture of ethyl acetate and ether. The hydrochloride so obtained melts at 327° to 329°C (with decomposition).

brand name

Neo-Synephrine II (Sterling Winthrop); Otrivin Hydrochloride (Ciba-Geigy).

Therapeutic Function

Adrenergic (vasopressor)

General Description

Xylometazoline hydrochloride is a derivative of imidazole, and a representative of the class of α1 agonists. It is commonly used in nasal decongestants, which works on the principle of constricting the blood vessels in the mucous membranes.

Biochem/physiol Actions

α-adrenoceptor agonist; imidazoline binding site ligand.

Safety Profile

Poison by ingestion, subcutaneous, intravenous, and intraperitoneal routes. When heated to decomposition it emits toxic fumes of NOx and HCl.

Xylometazoline hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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Xylometazoline hydrochloride Suppliers

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View Lastest Price from Xylometazoline hydrochloride manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD

Product: Xylometazoline hydrochloride 1218-35-5
Price: US $0.00-0.00/KG
Min. Order: 100g
Purity: 99.0%-101%
Supply Ability: 100 KGS
Release date: 2021-06-08

BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD.

Product: Xylometazoline Hydrochloride 1218-35-5
Price: US $0.00/g
Min. Order: 1g
Purity: More Than 99%
Supply Ability: 100kg/Month
Release date: 2024-11-13

Wuhan Senwayer Century Chemical Co.,Ltd

Product: Xylometazoline hydrochloride 1218-35-5
Price: US $0.00/g
Min. Order: 5g
Purity: 98%
Supply Ability: 500kg
Release date: 2023-02-08

1218-35-5, Xylometazoline hydrochloride Related Search:

tert-Butyl peroxyacetate Diethylene glycol monobutyl ether tert-Butyldimethylsilyl chloride Cefazolin Cefazolin sodium salt tert-Butyl acetate Benzyltriethylammonium chloride Dimethylbenzylcarbinyl acetate Buprofezin Butyl acetate 2-Tetralin-1-yl-4,5-dihydro-1H-imidazole hydrochloride Benzyl chloride Butyl acrylate 2-(4-TERT-BUTYL-2,6-DIMETHYL-BENZYL)-4,5-DIHYDRO-1H-IMIDAZOLE tert-Butanol Topotecan hydrochloride Benzyldimethylcarbinyl butyrate Cyhalofop-butyl

2-(4-tert-butyl-2,6-dimethylbenzyl)-2-imidazolinmonohydrochloride

2-[[4-(1,1-dimethylethyl)-2,6-dimethylphenyl]methyl]-4,5-dihydro-1h-imidazol

Galazolin

Neo-Rinoleina

Neo-Synephrine II

Novorin

Olynth

Therapin

XyMelin

2-[[4-(1,1-dimethylethyl)-2,6-dimethylphenyl]methyl]-4,5-dihydro-1H-imidazole,hydrochloride (1:1)

Xylometazoline hydrochloride, 98%, an α-adrenoceptor agonist

Oxymetazoline hydrochloride EP impurity B

otrivinehydrochloride

otrivinhydrochloride

XYLOMETAZOLINE HCL

XYLOMETAZOLINE HYDROCHLORIDE

XYLOMETAZOLIN HYDROCHLORIDE

2-(4-TERT-BUTYL-2,6-DIMETHYLBENZYL)-2-IMIDAZOLINE HYDROCHLORIDE

XYLOMETAZOLINE HYDROCHLORIDE CRYSTALLINE

1H-Imidazole, 2-4-(1,1-dimethylethyl)-2,6-dimethylphenylmethyl-4,5-dihydro-, monohydrochloride

XYLOMETAZOLINEHYDROCHLORIDE,USP

XYLONETAZOLINEHCL

2-(4-tert-Butyl-2,6-dimethylbenzyl)-4,5-dihydro-1H-imidazole hydrochloride

Xylometazoline hydrochloride, 2-(4-tert-Butyl-2,6-dimethylbenzyl)-2-imidazoline hydrochloride

Xylometazoline Hydrochloride (250 mg)

2-(4-tert-Butyl-2,6-diMethylbenzyl)-2-iMidazoline Monohydrochloride

2-[[4-(1,1-DiMethylethyl)-2,6-diMethylphenyl]Methyl]-4,5-dihydro-1H-iMidazole Hydrochlroide

Brizolin

yansuanshainuozuolin

2-[(4-tert-butyl-2,6-dimethylphenyl)methyl]-4,5-dihydro-1H-imidazole hydrochloride

Xylometazoline hydrochloride CRS

Xylometazoline HCl (Oxymetazoline EP Impurity B HCl)

Oxymetazoline EP Impurity B HCl(Xylometazoline HCl)

1H-Imidazole, 2-[[4-(1,1-dimethylethyl)-2,6-dimethylphenyl]methyl]-4,5-dihydro-, hydrochloride (1:1)

Xylometazoline hydrochloride USP/EP/BP

Oxymetazoline EP Impurity B (Xylometazoline)

Xylometazoline-D4 Hydrochloride

Xylometazoline Hydrochloride (1721002)

Oxymetazoline EP Impurity B HCl

Hydroxymetazoline EP impurity B hydrochloride

Oxymetazoline Hydrochloride EP Impurity B as Hydrochloride

Xylometazoline Impurity 1 HCl

Salozoline hydrochloride

Xylometazoline Hydrochloride, ≥ 98.0%

1218-35-5

1218-35-3

156-2-22

C16H24N2HClC16H25ClN2

C16H24N2xHCl

C16H24N2ClH

C16H24N2HCl

API

ALBENZA

Adrenoceptor

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